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Il17f Gene Detail
Summary
  • Symbol
    Il17f
  • Name
    interleukin 17F
  • Feature Type
    protein coding gene
  • IDs
    MGI:2676631
    NCBI Gene: 257630
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:20777146-20785274 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 6.49 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676631
protein coding gene Chr1:20777146-20790617 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015871
protein coding gene Chr1:18402595-18415991 (-)
A/J MGP_AJ_G0015852
protein coding gene Chr1:18183966-18197303 (-)
AKR/J MGP_AKRJ_G0015811
protein coding gene Chr1:18216103-18229445 (-)
BALB/cJ MGP_BALBcJ_G0015808
protein coding gene Chr1:17877131-17890468 (-)
C3H/HeJ MGP_C3HHeJ_G0015642
protein coding gene Chr1:18240186-18254608 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016262
protein coding gene Chr1:19268380-19281776 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013983
protein coding gene Chr1:16320856-16333708 (-)
CAST/EiJ MGP_CASTEiJ_G0015223
protein coding gene Chr1:18331802-18339368 (-)
CBA/J MGP_CBAJ_G0015615
protein coding gene Chr1:19704851-19718191 (-)
DBA/2J MGP_DBA2J_G0015714
protein coding gene Chr1:17677195-17690476 (-)
FVB/NJ MGP_FVBNJ_G0015719
protein coding gene Chr1:17441080-17454349 (-)
LP/J MGP_LPJ_G0015786
protein coding gene Chr1:18626861-18640798 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015737
protein coding gene Chr1:20658883-20672227 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016309
protein coding gene Chr1:18190638-18204006 (-)
PWK/PhJ MGP_PWKPhJ_G0015007
protein coding gene Chr1:17419767-17433387 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014788
protein coding gene Chr1:18289545-18304813 (-)
WSB/EiJ MGP_WSBEiJ_G0015286
protein coding gene Chr1:18123943-18138575 (-)



Homology
more
  • Human Ortholog
    IL17F, interleukin 17F
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IL17F, interleukin 17F
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CANDF6, IL-17F, ML1, ML-1
  • Links
    NCBI Gene ID: 112744
    neXtProt AC: NX_Q96PD4
    UniProt: Q96PD4

  • Chr Location
    6p12.2; chr6:52236681-52245689 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human IL17F associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 6 alleles in 4 genetic backgrounds
    10 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit increased susceptibility to oral bacterial infection while mice homozygous for another null allele exhibit decreased susceptibility to experimental models of colitis and CNS inflammation but have enhanced inflammatory responses to a chronic asthma model.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 257630 NCBI Gene Model | MGI Sequence Detail 8129 C57BL/6J ±  kb
    transcript NM_145856 RefSeq | MGI Sequence Detail 1178 Not Specified  
    polypeptide Q7TNI7 UniProt | EBI | MGI Sequence Detail 161 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2138720
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 66
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:292764 Hu B, et al., gammadelta T cells and adipocyte IL-17RC control fat innervation and thermogenesis. Nature. 2020 Feb;578(7796):610-614

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    11/10/2020
    MGI 6.16
    The Jackson Laboratory