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Il17f Gene Detail
Summary
  • Symbol
    Il17f
  • Name
    interleukin 17F
  • Feature Type
    protein coding gene
  • IDs
    MGI:2676631
    NCBI Gene: 257630
Location & Maps
more
  • Sequence Map
    Chr1:20777146-20790617 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13472 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IL17F, interleukin 17F
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IL17F, interleukin 17F
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CANDF6, IL-17F, ML1, ML-1
  • Links
    NCBI Gene ID: 112744
    neXtProt AC: NX_Q96PD4

  • Chr Location
    6p12; chr6:52236681-52245689 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human IL17F associations

Human Disease Mouse Models
       Candidiasis, Familial, 6; CANDF6   OMIM: 613956
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 6 alleles in 4 genetic backgrounds
    10 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit increased susceptibility to oral bacterial infection while mice homozygous for another null allele exhibit decreased susceptibility to experimental models of colitis and CNS inflammation but have enhanced inflammatory responses to a chronic asthma model.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048286 VEGA Gene Model | MGI Sequence Detail 13472 C57BL/6J ±  kb
transcript OTTMUST00000123902 VEGA | MGI Sequence Detail 1178 Not Applicable  
polypeptide OTTMUSP00000067535 VEGA | MGI Sequence Detail 161 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    197 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 3
    Other 1

    Microarray probesets 1
Other
Accession IDs
less
MGI:2138720
References
more
  • Summaries
    All 72
    Gene Ontology 9
    Phenotypes 42
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:226179 Sefik E, et al., MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORgamma(+) regulatory T cells. Science. 2015 Aug 28;349(6251):993-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory