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Il17f
Gene Detail
Symbol

Name
ID
Il17f
interleukin 17F
MGI:2676631
Feature Type
protein coding gene
Genetic Map
Chromosome 1
6.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:20777146-20790617 bp, - strand
From VEGA annotation of GRCm38

  13472 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17115  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog

HCOP human homology predictions: IL17F
Protein SuperFamily: interleukin-17
Gene Tree: Il17f

Human
homologs
IL17F, interleukin 17F
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 112744
neXtProt AC: NX_Q96PD4

Human Synonyms: CANDF6, IL-17F, ML1, ML-1

Human Chr (Location): 6p12; chr6:52236681-52245689 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IL17F

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(10) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for one null allele exhibit increased susceptibility to oral bacterial infection while mice homozygous for another null allele exhibit decreased susceptibility to experimental models of colitis and CNS inflammation but have enhanced inflammatory responses to a chronic asthma model.
 
Interactions
Il17f interacts with 76 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cartilage development, cytokine biosynthetic process, ...
Component extracellular region, extracellular space
Function cytokine activity, cytokine binding, ...
External Resources: FuncBase
Expression
cDNA source data(3)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(3) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000048286 (Evidence)
Ensembl Gene Model ENSMUSG00000041872 (Evidence)
Entrez Gene 257630 (Evidence)
UniGene 222807
DFCI TC1592421, TC1642571
DoTS DT.101216271, DT.524058
NIA Mouse Gene Index U021159
Consensus CDS Project CCDS35522.1
International Mouse Phenotyping Consortium Status Il17f
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048286 VEGA Gene Model | MGI Sequence Detail 13472 C57BL/6J ±  kb
transcript OTTMUST00000123902 VEGA | MGI Sequence Detail 1178 Not Applicable 
polypeptide OTTMUSP00000067535 VEGA | MGI Sequence Detail 161 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(197 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010345 Interleukin-17
InterPro IPR020440 Interleukin-17, chordata
Protein Ontology PR:000001142 interleukin-17F
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:211677 Fleige H, et al., IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med. 2014 Apr 7;211(4):643-51
All references(70)
Other
accession IDs
MGI:2138720

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory