Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL13
  • Mouse genes Il13
  • Rat genes Il13
  • Zfish genes il13
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il13

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005144	interleukin-13 receptor binding	Il13	IPI	RGD:628741	Rat	PMID:11573960|RGD:633067
Molecular Function	GO:0005515	protein binding	IL13	IPI	UniProtKB:P78552	Human	PMID:18243101
Molecular Function	GO:0005515	protein binding	IL13	IPI	UniProtKB:P78552	Human	PMID:20223216
Molecular Function	GO:0005515	protein binding	IL13	IPI	UniProtKB:Q14627	Human	PMID:20223216
Molecular Function	GO:0005515	protein binding	IL13	IPI	UniProtKB:Q14627	Human	PMID:23972995
Molecular Function	GO:0005515	protein binding	IL13	IPI	UniProtKB:Q14627	Human	PMID:27629921
Molecular Function	GO:0005515	protein binding	Il13	IPI	UniProtKB:O88786	Mouse	MGI:MGI:5522616|PMID:23972995
Molecular Function	GO:0005515	protein binding	Il13	IPI	UniProtKB:O88786	Mouse	MGI:MGI:5810479|PMID:27629921
Cellular Component	GO:0005737	cytoplasm	Il13	IDA		Mouse	PMID:11737071
Cellular Component	GO:0009897	external side of plasma membrane	Il13	IDA		Mouse	PMID:18792410
Cellular Component	GO:0009897	external side of plasma membrane	Il13	IDA		Mouse	PMID:19666510
Cellular Component	GO:0005576	extracellular region	IL13	IDA		Human	PMID:20041150
Cellular Component	GO:0005615	extracellular space	Il13	IDA		Mouse	PMID:15087456
Cellular Component	GO:0005615	extracellular space	Il13	IDA		Mouse	PMID:17082577
Cellular Component	GO:0005615	extracellular space	Il13	IDA		Mouse	PMID:16949315
Cellular Component	GO:0005615	extracellular space	Il13	IDA		Mouse	PMID:18997793
Cellular Component	GO:0005615	extracellular space	Il13	IDA		Mouse	PMID:21460847
Cellular Component	GO:0005615	extracellular space	Il13	IDA		Mouse	PMID:15240714
Cellular Component	GO:0005615	extracellular space	Il13	IDA		Mouse	PMID:16275384
Cellular Component	GO:0005615	extracellular space	Il13	IDA		Rat	PMID:17429054|RGD:2290347
Biological Process	GO:0071345	cellular response to cytokine stimulus	Il13	IDA		Mouse	PMID:19666510
Biological Process	GO:0071222	cellular response to lipopolysaccharide	il13	IDA		Zfish	PMID:27418527
Biological Process	GO:0071260	cellular response to mechanical stimulus	Il13	IEP		Rat	PMID:18362439|RGD:2298568
Biological Process	GO:0006954	inflammatory response	Il13	IMP	MGI:MGI:1931804	Mouse	PMID:15647285
Biological Process	GO:0042116	macrophage activation	IL13	IGI	UniProtKB:P05112	Human	PMID:30634164
Biological Process	GO:0001774	microglial cell activation	Il13	IMP		Rat	PMID:19752235|RGD:8549634
Biological Process	GO:1903660	negative regulation of complement-dependent cytotoxicity	IL13	IMP		Human	PMID:16034134
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	IL13	IMP		Human	PMID:16034134
Biological Process	GO:0050728	negative regulation of inflammatory response	IL13	IGI	UniProtKB:P05112	Human	PMID:30634164
Biological Process	GO:0050728	negative regulation of inflammatory response	il13	IGI	ZFIN:ZDB-GENO-211020-1,ZFIN:ZDB-GENO-211021-1	Zfish	PMID:32641385
Biological Process	GO:0050728	negative regulation of inflammatory response	il13	IMP	ZFIN:ZDB-GENO-211020-1	Zfish	PMID:32641385
Biological Process	GO:0033861	negative regulation of NAD(P)H oxidase activity	Il13	IMP		Rat	PMID:19752235|RGD:8549634
Biological Process	GO:1901215	negative regulation of neuron death	Il13	IMP		Rat	PMID:19752235|RGD:8549634
Biological Process	GO:0071635	negative regulation of transforming growth factor beta production	Il13	IDA		Rat	PMID:20100461|RGD:4145466
Biological Process	GO:0030890	positive regulation of B cell proliferation	Il13	IDA		Rat	PMID:10331006|RGD:61509
Biological Process	GO:0030890	positive regulation of B cell proliferation	Il13	IDA		Rat	PMID:11573960|RGD:633067
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Il13	IMP		Mouse	MGI:MGI:5603000|PMID:24906148
Biological Process	GO:0032723	positive regulation of connective tissue growth factor production	Il13	IDA		Rat	PMID:21804025|RGD:5684373
Biological Process	GO:0010628	positive regulation of gene expression	IL13	IGI	UniProtKB:P29965	Human	PMID:12574355
Biological Process	GO:0010628	positive regulation of gene expression	Il13	IDA		Rat	PMID:18941241|RGD:13825436
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Il13	IGI	MGI:MGI:96556	Mouse	PMID:15944273
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Il13	IMP	MGI:MGI:1931804	Mouse	PMID:15944273
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Il13	IDA		Rat	PMID:11573960|RGD:633067
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IL13	IGI	UniProtKB:P05112	Human	PMID:30634164
Biological Process	GO:0043032	positive regulation of macrophage activation	Il13	IMP		Mouse	MGI:MGI:4430159|PMID:19841166
Biological Process	GO:0043306	positive regulation of mast cell degranulation	Il13	IMP	MGI:MGI:1931804	Mouse	PMID:15944273
Biological Process	GO:0043306	positive regulation of mast cell degranulation	Il13	IGI	MGI:MGI:96556	Mouse	PMID:15944273
Biological Process	GO:0043270	positive regulation of monoatomic ion transport	Il13	IDA		Rat	PMID:11739109|RGD:2290361
Biological Process	GO:2000231	positive regulation of pancreatic stellate cell proliferation	Il13	IDA		Rat	PMID:20100461|RGD:4145466
Biological Process	GO:0050714	positive regulation of protein secretion	Il13	IDA		Rat	PMID:11739109|RGD:2290361
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	Il13	IDA		Rat	PMID:20045483|RGD:4145470
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Il13	IDA		Rat	PMID:20045483|RGD:4145470
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Il13	IDA		Rat	PMID:21804025|RGD:5684373
Biological Process	GO:0010155	regulation of proton transport	Il13	IDA		Rat	PMID:11739109|RGD:2290361
Biological Process	GO:0045471	response to ethanol	Il13	IEP		Rat	PMID:16698589|RGD:1581860
Biological Process	GO:0032496	response to lipopolysaccharide	Il13	IEP		Rat	PMID:16522370|RGD:2317671
Biological Process	GO:0009612	response to mechanical stimulus	Il13	IEP		Rat	PMID:18490768|RGD:2325984
Biological Process	GO:0035094	response to nicotine	Il13	IDA		Rat	PMID:18490768|RGD:2325984

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern