Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IGFBP6
  • Mouse genes Igfbp6
  • Rat genes Igfbp6
  • Zfish genes igfbp6a,igfbp6b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Igfbp6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	IGFBP6	IPI	UniProtKB:P24592	Human	PMID:32296183
Molecular Function	GO:0031994	insulin-like growth factor I binding	Igfbp6	IPI	RGD:70506	Rat	PMID:7689963|RGD:2301726
Molecular Function	GO:0031995	insulin-like growth factor II binding	IGFBP6	IMP		Human	PMID:15308688
Molecular Function	GO:0031995	insulin-like growth factor II binding	Igfbp6	IPI	RGD:737149	Rat	PMID:7689963|RGD:2301726
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:Q99623	Human	PMID:24003225
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:A6NI15	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:O00560	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:O14735	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:O14770-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:O43681	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:O43765	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:O95967	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:O95983-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:O95995	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:P05187	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:P26371	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:P29972	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:P49901	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:P53611	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:P61601	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:Q02930-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:Q12805	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:Q12837	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:Q6IQ23-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:Q6L8G8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:Q6VN20	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:Q7Z6N9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:Q8IYX3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:Q8TAU3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:Q96LT6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:Q96SQ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:Q9BSL1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:Q9H0I2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:Q9UM22	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:Q9UMX0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP6	IPI	UniProtKB:X5D778	Human	PMID:32296183
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Igfbp6	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0005737	cytoplasm	Igfbp6	IDA		Rat	PMID:14515325|RGD:2301718
Cellular Component	GO:0005615	extracellular space	Igfbp6	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Igfbp6	IDA		Rat	PMID:7689963|RGD:2301726
Cellular Component	GO:0005794	Golgi apparatus	Igfbp6	IDA		Rat	PMID:14515325|RGD:2301718
Cellular Component	GO:0042568	insulin-like growth factor binary complex	IGFBP6	IMP		Human	PMID:15308688
Biological Process	GO:0016477	cell migration	IGFBP6	IDA		Human	PMID:24003225
Biological Process	GO:0043410	positive regulation of MAPK cascade	IGFBP6	IDA		Human	PMID:24003225
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	IGFBP6	IDA		Human	PMID:24003225

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern