Igfbp6
Gene Detail

Symbol Name ID

Igfbp6 insulin-like growth factor binding protein 6 MGI:96441

Synonyms

IGFBP-6

Feature Type

protein coding gene

Genetic Map

Chromosome 15

57.32 cM
Detailed Genetic Map ± 1 cM

Sequence Map

Chr15:102144362-102149511 bp, + strand From VEGA annotation of GRCm38   5150 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1641  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: insulin-like growth factor binding protein
Gene Tree: Igfbp6

Human homologs

Human Homolog		IGFBP6, insulin-like growth factor binding protein 6
NCBI Gene ID		3489
neXtProt AC		NX_P24592
Human Synonyms		IBP6
Human Chr (Location)		12q13; chr12:53491436-53496128 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(3) Gene trapped(3)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	regulation of cell growth
Component	cytoplasm, extracellular region, ...
Function	growth factor binding, insulin-like growth factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (35)    Tissues (30)    Images (1)
Theiler Stages: 1, 2, 3, 4, 5, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	1
Northern blot	19
RT-PCR	15

cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) cDNA(40) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035011 (Evidence)
Ensembl Gene Model	ENSMUSG00000023046 (Evidence)
Entrez Gene	16012 (Evidence)
UniGene	358609
DFCI	TC1579263, TC1630158
DoTS	DT.531214
NIA Mouse Gene Index	U016698
Consensus CDS Project	CCDS27871.1
International Mouse Knockout Project Status	Igfbp6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035011	VEGA Gene Model | MGI Sequence Detail	5150	C57BL/6J
transcript	OTTMUST00000089026	VEGA | MGI Sequence Detail	1112	Not Applicable
polypeptide	OTTMUSP00000048594	VEGA | MGI Sequence Detail	238	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(12 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009168	Insulin-like growth factor binding protein
InterPro	IPR022326	Insulin-like growth factor-binding protein 6
InterPro	IPR022321	Insulin-like growth factor-binding protein family 1-6, chordata
InterPro	IPR000867	Insulin-like growth factor-binding protein, IGFBP
InterPro	IPR009030	Insulin-like growth factor binding protein, N-terminal
InterPro	IPR017891	Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro	IPR000716	Thyroglobulin type-1
Protein Ontology	PR:000008952	insulin-like growth factor-binding protein 6

References

(Earliest) J:12803 Schuller AG, et al., Gene expression of the six insulin-like growth factor binding proteins in the mouse conceptus during mid- and late gestation. Endocrinology. 1993 Jun;132(6):2544-50
(Latest) J:187514 Shibata S, et al., An in situ hybridization study of the insulin-like growth factor system in developing condylar cartilage of the fetal mouse mandible. Eur J Histochem. 2012;56(2):e23
All references(48)

Other accession IDs

MGD-MRK-11238