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Igfbp6
Gene Detail
 Symbol
Name
ID
Igfbp6
insulin-like growth factor binding protein 6
MGI:96441
Synonyms IGFBP-6
Feature Type protein coding gene
Genetic Map
Chromosome 15
57.32 cM
Detailed Genetic Map ± 1 cM

Sequence Map
Chr15:102144362-102149511 bp, + strand
From VEGA annotation of GRCm38

  5150 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1641  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: insulin-like growth factor binding protein
Gene Tree: Igfbp6

Human
homologs
Human Homolog IGFBP6, insulin-like growth factor binding protein 6
NCBI Gene ID 3489
neXtProt AC  NX_P24592
Human Synonyms  IBP6
Human Chr (Location)  12q13; chr12:53097652-53102344 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Radiation induced(1) Targeted(3)
Genomic Mutations involving Igfbp6 (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Igfbp6 interacts with 23 markers (Mir15a, Mir15b, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process regulation of cell growth, regulation of insulin-like growth factor receptor signaling pathway
Component cytoplasm, extracellular region, ...
Function growth factor binding, insulin-like growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (60)    Tissues (47)    Images (13)
Theiler Stages: 1, 2, 3, 4, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 15
RNA in situ 2
Northern blot 19
RT-PCR 24
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) cDNA(41) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035011 (Evidence)
Ensembl Gene ModelENSMUSG00000023046 (Evidence)
Entrez Gene16012 (Evidence)
UniGene358609
DFCITC1579263, TC1630158
DoTSDT.531214
NIA Mouse Gene IndexU016698
Consensus CDS ProjectCCDS27871.1
International Mouse Knockout Project StatusIgfbp6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035011 VEGA Gene Model | MGI Sequence Detail 5150 C57BL/6J ±  kb
transcript OTTMUST00000089026 VEGA | MGI Sequence Detail 1112 Not Applicable 
polypeptide OTTMUSP00000048594 VEGA | MGI Sequence Detail 238 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(33 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009168 Insulin-like growth factor binding protein
InterPro IPR022326 Insulin-like growth factor-binding protein 6
InterPro IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
InterPro IPR000867 Insulin-like growth factor-binding protein, IGFBP
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro IPR000716 Thyroglobulin type-1
Protein Ontology PR:000008952 insulin-like growth factor-binding protein 6
References (Earliest) J:12803 Schuller AG, et al., Gene expression of the six insulin-like growth factor binding proteins in the mouse conceptus during mid- and late gestation. Endocrinology. 1993 Jun;132(6):2544-50
(Latest) J:201076 Okano T, et al., Expression of insulin-like growth factor binding proteins during mouse cochlear development. Dev Dyn. 2013 Oct;242(10):1210-21
All references(52)
Other
accession IDs
MGD-MRK-11238

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory