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Igfbp6
Gene Detail
Symbol

Name
ID
Igfbp6
insulin-like growth factor binding protein 6
MGI:96441
Synonyms
IGFBP-6
Feature Type
protein coding gene
Genetic Map
Chromosome 15
57.32 cM
Detailed Genetic Map ± 1 cM

Sequence Map
Chr15:102144362-102149511 bp, + strand
From VEGA annotation of GRCm38

  5150 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1641  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: IGFBP6
Protein SuperFamily: insulin-like growth factor binding protein
Gene Tree: Igfbp6

Human
homologs
IGFBP6, insulin-like growth factor binding protein 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3489
neXtProt AC: NX_P24592

Human Synonyms: IBP6

Human Chr (Location): 12q13; chr12:53097652-53102344 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Radiation induced(1) Targeted(3)
Genomic Mutations involving Igfbp6 (1)
Incidental mutations (data from Mutagenetix , APF )
Phenotype Images(2)
Interactions
Igfbp6 interacts with 23 markers (Mir15a, Mir15b, Mir92-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (20 records)
Data Summary: Results (60)    Tissues (47)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 15
RNA in situ 2
Northern blot 19
RT-PCR 24
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN igfbp6a, igfbp6b    NEW 
Molecular
reagents
All nucleic(44) cDNA(41) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035011 (Evidence)
Ensembl Gene Model ENSMUSG00000023046 (Evidence)
Entrez Gene 16012 (Evidence)
UniGene 358609
DFCI TC1579263, TC1630158
DoTS DT.531214
NIA Mouse Gene Index U016698
Consensus CDS Project CCDS27871.1
International Mouse Phenotyping Consortium Status Igfbp6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035011 VEGA Gene Model | MGI Sequence Detail 5150 C57BL/6J ±  kb
transcript OTTMUST00000089026 VEGA | MGI Sequence Detail 1112 Not Applicable 
polypeptide OTTMUSP00000048594 VEGA | MGI Sequence Detail 238 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(33 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009168 Insulin-like growth factor binding protein
InterPro IPR022326 Insulin-like growth factor-binding protein 6
InterPro IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
InterPro IPR000867 Insulin-like growth factor-binding protein, IGFBP
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro IPR000716 Thyroglobulin type-1
Protein Ontology PR:000008952 insulin-like growth factor-binding protein 6
References
(Earliest) J:12803 Schuller AG, et al., Gene expression of the six insulin-like growth factor binding proteins in the mouse conceptus during mid- and late gestation. Endocrinology. 1993 Jun;132(6):2544-50
(Latest) J:211117 Pais RS, et al., Transcriptome analysis in prenatal IGF1-deficient mice identifies molecular pathways and target genes involved in distal lung differentiation. PLoS One. 2013;8(12):e83028
All references(51)
Other
accession IDs
MGD-MRK-11238

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory