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Igfbp6 Gene Detail
Summary
  • Symbol
    Igfbp6
  • Name
    insulin-like growth factor binding protein 6
  • Synonyms
    IGFBP-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:96441
    NCBI Gene: 16012
  • Gene Overview
    MyGene.info: IGFBP6
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:102144362-102149511 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 57.32 cM
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96441
protein coding gene Chr15:102144186-102149512 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022400
protein coding gene Chr15:104295490-104300775 (+)
A/J MGP_AJ_G0022362
protein coding gene Chr15:100204150-100208923 (+)
AKR/J MGP_AKRJ_G0022337
protein coding gene Chr15:103234166-103239285 (+)
BALB/cJ MGP_BALBcJ_G0022366
protein coding gene Chr15:100247090-100252206 (+)
C3H/HeJ MGP_C3HHeJ_G0022133
protein coding gene Chr15:103311006-103315781 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022815
protein coding gene Chr15:108176395-108181495 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020338
protein coding gene Chr15:95979201-95984001 (+)
CAST/EiJ MGP_CASTEiJ_G0021659
protein coding gene Chr15:104166724-104172450 (+)
CBA/J MGP_CBAJ_G0022102
protein coding gene Chr15:111957471-111962360 (+)
DBA/2J MGP_DBA2J_G0022233
protein coding gene Chr15:99491254-99496375 (+)
FVB/NJ MGP_FVBNJ_G0022209
protein coding gene Chr15:98548535-98556739 (+)
LP/J MGP_LPJ_G0022302
protein coding gene Chr15:104454768-104463377 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022231
protein coding gene Chr15:115549463-115554595 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022827
protein coding gene Chr15:103256625-103261762 (+)
PWK/PhJ MGP_PWKPhJ_G0021399
protein coding gene Chr15:99639921-99645564 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021231
protein coding gene Chr15:103101709-103106478 (+)
WSB/EiJ MGP_WSBEiJ_G0021709
protein coding gene Chr15:103884703-103891704 (+)



Homology
more
  • Human Ortholog
    IGFBP6, insulin like growth factor binding protein 6
  • Vertebrate Orthologs
    6
  • Human Ortholog
    IGFBP6, insulin like growth factor binding protein 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IBP6
  • Links
    NCBI Gene ID: 3489
    neXtProt AC: NX_P24592
    UniProt: P24592

  • Chr Location
    12q13.13; chr12:53097503-53102344 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023046 Ensembl Gene Model | MGI Sequence Detail 5150 C57BL/6J ±  kb
transcript ENSMUST00000023807 Ensembl | MGI Sequence Detail 1112 Not Applicable  
polypeptide ENSMUSP00000023807 Ensembl | MGI Sequence Detail 238 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008952 insulin-like growth factor-binding protein 6
  • InterPro Domains
    IPR009030 Growth factor receptor cysteine-rich domain superfamily
    IPR009168 Insulin-like growth factor binding protein
    IPR022326 Insulin-like growth factor-binding protein 6
    IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
    IPR000867 Insulin-like growth factor-binding protein, IGFBP
    IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
    IPR000716 Thyroglobulin type-1
    IPR036857 Thyroglobulin type-1 superfamily
Molecular
Reagents
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  • All nucleic 45
    cDNA 42
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11238
References
more
  • Summaries
    All 75
    Developmental Gene Expression 22
    Diseases 1
    Gene Ontology 7
    Phenotypes 22
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:241923 Lopez IP, et al., Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation. PLoS One. 2016;11(11):e0166388

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory