Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IFT74
  • Mouse genes Ift74
  • Rat genes Ift74
  • Zfish genes ift74
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ift74

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048487	beta-tubulin binding	IFT74	IDA		Human	PMID:23990561
Molecular Function	GO:0003682	chromatin binding	Ift74	IDA		Mouse	PMID:20545763
Molecular Function	GO:0005515	protein binding	IFT74	IPI	UniProtKB:Q8WYA0	Human	PMID:28428259
Molecular Function	GO:0005515	protein binding	IFT74	IPI	UniProtKB:Q9UNT1	Human	PMID:28428259
Molecular Function	GO:0005515	protein binding	IFT74	IPI	UniProtKB:Q8WYA0	Human	PMID:28625565
Molecular Function	GO:0005515	protein binding	IFT74	IPI	UniProtKB:Q9UNT1	Human	PMID:28625565
Cellular Component	GO:0005813	centrosome	Ift74	IDA		Mouse	PMID:19253336
Cellular Component	GO:0005929	cilium	Ift74	IDA		Mouse	PMID:19253336
Cellular Component	GO:0030992	intraciliary transport particle B	IFT74	IPI		Human	PMID:26980730
Cellular Component	GO:0030992	intraciliary transport particle B	Ift74	IDA		Mouse	MGI:MGI:5613829|PMID:25443296
Cellular Component	GO:0030992	intraciliary transport particle B	Ift74	IDA		Mouse	MGI:MGI:5607391|PMID:24596149
Cellular Component	GO:0030992	intraciliary transport particle B	Ift74	IDA		Mouse	PMID:23810713
Cellular Component	GO:0030992	intraciliary transport particle B	Ift74	IDA		Mouse	PMID:19253336
Cellular Component	GO:0005634	nucleus	Ift74	IDA		Mouse	PMID:20545763
Cellular Component	GO:0005634	nucleus	Ift74	IDA		Mouse	PMID:16705683
Biological Process	GO:0060271	cilium assembly	IFT74	IMP		Human	PMID:23990561
Biological Process	GO:0007368	determination of left/right symmetry	Ift74	IMP		Mouse	PMID:25807483
Biological Process	GO:0008544	epidermis development	Ift74	IMP		Mouse	PMID:21703454
Biological Process	GO:0007369	gastrulation	ift74	IMP	ZFIN:ZDB-MRPHLNO-161012-10	Zfish	PMID:27486776
Biological Process	GO:0007369	gastrulation	ift74	IMP	ZFIN:ZDB-CRISPR-161012-1	Zfish	PMID:27486776
Biological Process	GO:0007369	gastrulation	ift74	IMP	ZFIN:ZDB-MRPHLNO-161012-11	Zfish	PMID:27486776
Biological Process	GO:0007507	heart development	Ift74	IMP		Mouse	PMID:25807483
Biological Process	GO:0035735	intraciliary transport involved in cilium assembly	IFT74	IMP		Human	PMID:23990561
Biological Process	GO:0003334	keratinocyte development	Ift74	IMP		Mouse	PMID:21703454
Biological Process	GO:0043616	keratinocyte proliferation	Ift74	IMP		Mouse	PMID:21703454
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Ift74	IMP		Mouse	PMID:21703454
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	Ift74	IMP		Mouse	PMID:21703454
Biological Process	GO:1905515	non-motile cilium assembly	Ift74	IMP		Mouse	PMID:21703454
Biological Process	GO:0007219	Notch signaling pathway	Ift74	IMP		Mouse	PMID:21703454
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	Ift74	IMP		Mouse	PMID:20545763
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ift74	IDA		Mouse	PMID:20545763
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ift74	IMP		Mouse	PMID:16705683
Biological Process	GO:0035776	pronephric proximal tubule development	ift74	IMP	ZFIN:ZDB-MRPHLNO-161012-10	Zfish	PMID:27486776
Biological Process	GO:0035776	pronephric proximal tubule development	ift74	IMP	ZFIN:ZDB-MRPHLNO-161012-11	Zfish	PMID:27486776
Biological Process	GO:0035776	pronephric proximal tubule development	ift74	IMP	ZFIN:ZDB-CRISPR-161012-1	Zfish	PMID:27486776
Biological Process	GO:1902017	regulation of cilium assembly	ift74	IMP	ZFIN:ZDB-MRPHLNO-161012-11	Zfish	PMID:33531668

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern