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Ift74 Gene Detail
Summary
  • Symbol
    Ift74
  • Name
    intraflagellar transport 74
  • Synonyms
    1700029H06Rik, b2b796Clo, Ccdc2, Cmg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914944
    NCBI Gene: 67694
  • Gene Overview
    MyGene.info: IFT74
Location & Maps
more
  • Sequence Map
    Chr4:94614491-94693229 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      78739 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 43.34 cM, cytoband C5
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    IFT74, intraflagellar transport 74
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IFT74, intraflagellar transport 74
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CCDC2, CMG1, CMG-1
  • Links
    NCBI Gene ID: 80173
    neXtProt AC: NX_Q96LB3

  • Chr Location
    9p21.2; chr9:26947039-27066129 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11831
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: IFT74
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    11 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    28
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    21
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Ift74
  • Incidental Mutations
Mice homozygous for an ENU-induced mutation exhibit complex congenital heart disease associated with heterotaxy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007856 VEGA Gene Model | MGI Sequence Detail 78739 C57BL/6J ±  kb
transcript OTTMUST00000017883 VEGA | MGI Sequence Detail 2139 Not Applicable  
polypeptide OTTMUSP00000008217 VEGA | MGI Sequence Detail 600 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    338 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008937 intraflagellar transport protein 74
  • InterPro Domains
    IPR029602 Intraflagellar transport protein 74
Molecular
Reagents
less
  • All nucleic 41
    cDNA 41

    Microarray probesets 5
Other
Accession IDs
less
MGI:5311340
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 11
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory