Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ICMT
  • Mouse genes Icmt
  • Rat genes Icmt
  • Zfish genes icmt
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Icmt

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008140	cAMP response element binding protein binding	Icmt	IMP	MGI:MGI:3033709	Mouse	PMID:14966563
Molecular Function	GO:0005515	protein binding	ICMT	IPI	UniProtKB:P15941-11	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ICMT	IPI	UniProtKB:P48051	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ICMT	IPI	UniProtKB:Q13049	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ICMT	IPI	UniProtKB:Q13113	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ICMT	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ICMT	IPI	UniProtKB:Q3SXY8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ICMT	IPI	UniProtKB:Q6ZMZ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ICMT	IPI	UniProtKB:Q8N5M9	Human	PMID:32296183
Molecular Function	GO:0004671	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	ICMT	IDA		Human	PMID:29051265
Molecular Function	GO:0004671	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	Icmt	IMP	MGI:MGI:2680650	Mouse	PMID:11121396
Molecular Function	GO:0004671	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	Icmt	IMP	MGI:MGI:2680650	Mouse	PMID:10747846
Molecular Function	GO:0004671	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	Icmt	IMP		Rat	PMID:9192075|RGD:2289655
Cellular Component	GO:0005783	endoplasmic reticulum	ICMT	IDA		Human	PMID:9614111
Cellular Component	GO:0016020	membrane	Icmt	IDA		Rat	PMID:9192075|RGD:2289655
Biological Process	GO:0030282	bone mineralization	Icmt	IGI	MGI:MGI:1890508	Mouse	PMID:23686339
Biological Process	GO:0006481	C-terminal protein methylation	Icmt	IMP	MGI:MGI:2680650	Mouse	PMID:10747846
Biological Process	GO:0006481	C-terminal protein methylation	Icmt	IMP		Rat	PMID:9192075|RGD:2289655
Biological Process	GO:0008340	determination of adult lifespan	Icmt	IGI	MGI:MGI:1890508	Mouse	PMID:23686339
Biological Process	GO:0048144	fibroblast proliferation	Icmt	IMP	MGI:MGI:3033709	Mouse	PMID:14966563
Biological Process	GO:0001701	in utero embryonic development	Icmt	IMP	MGI:MGI:2680650	Mouse	PMID:11121396
Biological Process	GO:0001701	in utero embryonic development	Icmt	IMP	MGI:MGI:2183607	Mouse	PMID:12105862
Biological Process	GO:0001889	liver development	Icmt	IMP	MGI:MGI:2183607	Mouse	PMID:12105862
Biological Process	GO:0035264	multicellular organism growth	Icmt	IGI	MGI:MGI:1890508	Mouse	PMID:23686339
Biological Process	GO:0035264	multicellular organism growth	Icmt	IMP	MGI:MGI:2680650	Mouse	PMID:11121396
Biological Process	GO:0050905	neuromuscular process	Icmt	IGI	MGI:MGI:1890508	Mouse	PMID:23686339
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Icmt	IMP	MGI:MGI:3033709	Mouse	PMID:14966563
Biological Process	GO:0008104	protein localization	Icmt	IMP	MGI:MGI:2680650	Mouse	PMID:10747846
Biological Process	GO:0006479	protein methylation	Icmt	IMP	MGI:MGI:2680650	Mouse	PMID:11121396
Biological Process	GO:2000772	regulation of cellular senescence	Icmt	IGI	MGI:MGI:1890508	Mouse	PMID:23686339
Biological Process	GO:0032880	regulation of protein localization	Icmt	IMP	MGI:MGI:3033709	Mouse	PMID:23686339
Biological Process	GO:0046578	regulation of Ras protein signal transduction	Icmt	IGI	MGI:MGI:96680	Mouse	PMID:14966563
Biological Process	GO:0046498	S-adenosylhomocysteine metabolic process	Icmt	IMP		Rat	PMID:9192075|RGD:2289655
Biological Process	GO:0046499	S-adenosylmethioninamine metabolic process	Icmt	IMP		Rat	PMID:9192075|RGD:2289655
Biological Process	GO:0031929	TOR signaling	Icmt	IMP	MGI:MGI:3033709	Mouse	PMID:23686339

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern