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Icmt
Gene Detail
Symbol

Name
ID
Icmt
isoprenylcysteine carboxyl methyltransferase
MGI:1888594
Synonyms
1700008E11Rik, Gm13095, HSTE14, pcCMT, prenylated protein carboxyl methyltransferase, prenylcysteine carboxyl methyltransferase, protein-S isoprenylcysteine O-methyltransferase, STE14
Feature Type
protein coding gene
Genetic Map
Chromosome 4
83.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:152297227-152307121 bp, + strand
From VEGA annotation of GRCm38

  9895 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5735  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ICMT
Gene Tree: Icmt

Human
homologs
ICMT, isoprenylcysteine carboxyl methyltransferase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23463
neXtProt AC: NX_O60725

Human Synonyms: HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT

Human Chr (Location): 1p36.21; chr1:6221193-6235984 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(5) Targeted(8)
Genomic Mutations involving Icmt (3)
 
Targeted null mutations result in reduced embryo size and death by E12. At E10.5, embryos homozygous for one null allele show severe anemia, extensive apoptosis in the neural tube and forebrain region, and liver agenesis due to a dramatic delay in albumin induction and failed hepatocyte outgrowth.
 
Interactions
Icmt interacts with 320 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (117)    Tissues (107)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
Northern blot 12
RT-PCR 2
cDNA source data(129)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase icmt ; ZFIN icmt    NEW 
Molecular
reagents
All nucleic(133) cDNA(130) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000010407 (Evidence)
Ensembl Gene Model ENSMUSG00000039662 (Evidence)
Entrez Gene 57295 (Evidence)
UniGene 277464
DFCI TC1729938, TC1577288, TC1629637, TC1606207, TC1624909, TC1610147
DoTS DT.94194402, DT.91338036
NIA Mouse Gene Index U005167
EC 2.1.1.100
Consensus CDS Project CCDS18998.1
International Mouse Phenotyping Consortium Status Icmt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010407 VEGA Gene Model | MGI Sequence Detail 9895 C57BL/6J ±  kb
transcript OTTMUST00000024264 VEGA | MGI Sequence Detail 4919 Not Applicable 
polypeptide OTTMUSP00000011160 VEGA | MGI Sequence Detail 284 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(3) UniProt(3)
Polymorphisms
SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007269 Isoprenylcysteine carboxyl methyltransferase
InterPro IPR025770 Protein-S-isoprenylcysteine O-methyltransferase
Protein Ontology PR:000008884 protein-S-isoprenylcysteine O-methyltransferase
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:204180 Court H, et al., Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. J Clin Invest. 2013 Oct 8;
All references(44)
Other
accession IDs
MGI:1916534, MGI:2140687, MGI:3723264

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory