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Icmt
Gene Detail
 Symbol
Name
ID
Icmt
isoprenylcysteine carboxyl methyltransferase
MGI:1888594
Synonyms 1700008E11Rik, Gm13095, HSTE14, pcCMT, prenylated protein carboxyl methyltransferase, prenylcysteine carboxyl methyltransferase, protein-S isoprenylcysteine O-methyltransferase, STE14
Feature Type protein coding gene
Genetic Map
Chromosome 4
83.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:152297227-152307121 bp, + strand
From VEGA annotation of GRCm38

  9895 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5735  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Icmt

Human
homologs
Human Homolog ICMT, isoprenylcysteine carboxyl methyltransferase
NCBI Gene ID 23463
neXtProt AC  NX_O60725
Human Synonyms  HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT
Human Chr (Location)  1p36.21; chr1:6221193-6235984 (-)  GRCh38
Alleles
and
phenotypes
All alleles(10) : Gene trapped(5) Targeted(5)
 
Targeted null mutations result in reduced embryo size and death by E12. At E10.5, embryos homozygous for one null allele show severe anemia, extensive apoptosis in the neural tube and forebrain region, and liver agenesis due to a dramatic delay in albumin induction and failed hepatocyte outgrowth.
 
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process C-terminal protein methylation, in utero embryonic development, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function cAMP response element binding protein binding, methyltransferase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (117)    Tissues (106)    Images (18)
Theiler Stages: 17, 22, 24, 28
Assay TypeResults
RNA in situ 103
Northern blot 12
RT-PCR 2
cDNA source data(129)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(133) cDNA(130) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000010407 (Evidence)
Ensembl Gene ModelENSMUSG00000039662 (Evidence)
Entrez Gene57295 (Evidence)
UniGene277464
DFCITC1577288, TC1606207, TC1610147, TC1624909, TC1629637, TC1729938
DoTSDT.91338036, DT.94194402
NIA Mouse Gene IndexU005167
EC2.1.1.100
Consensus CDS ProjectCCDS18998.1
International Mouse Knockout Project StatusIcmt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010407 VEGA Gene Model | MGI Sequence Detail 9895 C57BL/6J ±  kb
transcript OTTMUST00000024264 VEGA | MGI Sequence Detail 4919 Not Applicable 
polypeptide OTTMUSP00000011160 VEGA | MGI Sequence Detail 284 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(3) UniProt(3)
Polymorphisms SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007269 Isoprenylcysteine carboxyl methyltransferase
InterPro IPR025770 Protein-S-isoprenylcysteine O-methyltransferase
Protein Ontology PR:000008884 protein-S-isoprenylcysteine O-methyltransferase
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:204180 Court H, et al., Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. J Clin Invest. 2013 Oct 8;
All references(45)
Other
accession IDs
MGI:1916534, MGI:2140687, MGI:3723264

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory