About   Help   FAQ
Icmt Gene Detail
Summary
  • Symbol
    Icmt
  • Name
    isoprenylcysteine carboxyl methyltransferase
  • Synonyms
    1700008E11Rik, Gm13095, HSTE14, pcCMT, prenylated protein carboxyl methyltransferase, prenylcysteine carboxyl methyltransferase, protein-S isoprenylcysteine O-methyltransferase, STE14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888594
    NCBI Gene: 57295
  • Gene Overview
    MyGene.info: ICMT
Location & Maps
more
  • Sequence Map
    Chr4:152297227-152307121 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9895 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 83.02 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ICMT, isoprenylcysteine carboxyl methyltransferase
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ICMT, isoprenylcysteine carboxyl methyltransferase
    Orthology source: HomoloGene
  • Synonyms
    HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT
  • Links
    NCBI Gene ID: 23463
    neXtProt AC: NX_O60725

  • Chr Location
    1p36.21; chr1:6221193-6235984 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Gene trapped
    5
  • Targeted
    8
  • Genomic Mutations
    3 involving Icmt
Targeted null mutations result in reduced embryo size and death by E12. At E10.5, embryos homozygous for one null allele show severe anemia, extensive apoptosis in the neural tube and forebrain region, and liver agenesis due to a dramatic delay in albumin induction and failed hepatocyte outgrowth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010407 VEGA Gene Model | MGI Sequence Detail 9895 C57BL/6J ±  kb
transcript OTTMUST00000024264 VEGA | MGI Sequence Detail 4919 Not Applicable  
polypeptide OTTMUSP00000011160 VEGA | MGI Sequence Detail 284 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    92 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008884 protein-S-isoprenylcysteine O-methyltransferase
  • EC
  • InterPro Domains
    IPR007269 Isoprenylcysteine carboxyl methyltransferase
    IPR025770 Protein-S-isoprenylcysteine O-methyltransferase
Molecular
Reagents
less
  • All nucleic 133
    cDNA 130
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1916534, MGI:2140687, MGI:3723264
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 17
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:231728 Christiansen JR, et al., Deficiency of Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Leads to Progressive Loss of Photoreceptor Function. J Neurosci. 2016 May 4;36(18):5107-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory