Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HTRA3
  • Mouse genes Htra3
  • Rat genes Htra3
  • Zfish genes htra3a,htra3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Htra3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	HTRA3	IDA		Human	PMID:18387192
Molecular Function	GO:0042802	identical protein binding	HTRA3	IPI	UniProtKB:P83110	Human	PMID:26110759
Molecular Function	GO:0042802	identical protein binding	HTRA3	IPI	UniProtKB:P83110	Human	PMID:31899476
Molecular Function	GO:0005515	protein binding	HTRA3	IPI	UniProtKB:P35579	Human	PMID:22229724
Molecular Function	GO:0005515	protein binding	HTRA3	IPI	UniProtKB:P83105	Human	PMID:25002585
Molecular Function	GO:0005515	protein binding	HTRA3	IPI	UniProtKB:P02666	Human	PMID:26110759
Molecular Function	GO:0005515	protein binding	HTRA3	IPI	UniProtKB:P17987	Human	PMID:29477555
Molecular Function	GO:0005515	protein binding	HTRA3	IPI	UniProtKB:P60709	Human	PMID:29477555
Molecular Function	GO:0005515	protein binding	HTRA3	IPI	UniProtKB:P98170	Human	PMID:31260151
Molecular Function	GO:0005515	protein binding	HTRA3	IPI	UniProtKB:P02666	Human	PMID:31470122
Molecular Function	GO:0005515	protein binding	HTRA3	IPI	UniProtKB:P98170	Human	PMID:31470122
Molecular Function	GO:0005515	protein binding	HTRA3	IPI	UniProtKB:P02666	Human	PMID:31899476
Molecular Function	GO:0005515	protein binding	Htra3	IPI	UniProtKB:P04202|UniProtKB:P21275|UniProtKB:P27090|UniProtKB:P43027	Mouse	MGI:MGI:3046453|PMID:15206957
Molecular Function	GO:0008236	serine-type peptidase activity	HTRA3	IDA		Human	PMID:22229724
Molecular Function	GO:0008236	serine-type peptidase activity	Htra3	IDA		Mouse	MGI:MGI:3046453|PMID:15206957
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Htra3	IDA		Mouse	MGI:MGI:3046453|PMID:15206957
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Htra3	IDA		Mouse	MGI:MGI:3046453|PMID:15206957
Biological Process	GO:0006508	proteolysis	HTRA3	IDA		Human	PMID:18387192
Biological Process	GO:0006508	proteolysis	HTRA3	IDA		Human	PMID:22229724
Biological Process	GO:0006508	proteolysis	Htra3	IDA		Mouse	MGI:MGI:3046453|PMID:15206957

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern