Htra3 MGI Mouse Gene Detail - MGI:1925808

Htra3 Gene Detail

Symbol

Htra3
Name

HtrA serine peptidase 3
Synonyms

2210021K23Rik, 9530081K03Rik

Feature Type

protein coding gene
IDs

MGI:1925808
NCBI Gene: 78558
Alliance

gene page

Sequence Map

Chr5:35652023-35679782 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

27760 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 18.49 cM, cytoband B1
Mapping Data

2 experiments

Human Ortholog

HTRA3, HtrA serine peptidase 3

Vertebrate Orthologs

10

Human Ortholog

HTRA3, HtrA serine peptidase 3
Orthology source: HomoloGene, HGNC
Synonyms

Prsp, Tasp
Links

HGNC:30406

NCBI Gene ID: 94031

neXtProt AC: NX_P83110

UniProt: P83110
Chr Location

4p16.1; chr4:8269757-8307111 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 12697
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: HTRA3
Protein SuperFamily

serine protease, HTRA type
Gene Tree

Htra3

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References

1 with disease annotations

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Phenotype Summary

25 phenotype references

All Mutations and Alleles

12
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

1
Radiation induced

4
Spontaneous

1
Targeted

3
Genomic Mutations

8 involving Htra3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

10 strains or lines available

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All GO Annotations

15
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

9
Tissues

4
cDNA Data

68
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase htra3

ZFIN htra3a

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Htra3 interacts with 162 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

50
RefSeq

8
UniProt

4
CCDS

CCDS19233.1, CCDS39071.1
UniGene

274255

			Length	Strain/Species	Flank
genomic	OTTMUSG00000024097	VEGA Gene Model \| MGI Sequence Detail	27760	C57BL/6J	± kb
transcript	OTTMUST00000058943	VEGA \| MGI Sequence Detail	2750	Not Applicable
polypeptide	OTTMUSP00000028630	VEGA \| MGI Sequence Detail	459	Not Applicable

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SNPs within 2kb

287 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000031746 serine protease HTRA3

(term hierarchy)
EC

3.4.21.-
InterPro Domains

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR000867 Insulin-like growth factor-binding protein, IGFBP

IPR002350 Kazal domain

IPR036058 Kazal domain superfamily

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR001940 Peptidase S1C

IPR009003 Peptidase S1, PA clan

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All nucleic 68

cDNA 68

Microarray probesets 7

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MGI:1921510

Summaries

All 51

Developmental Gene Expression 2

Diseases 1

Gene Ontology 4

Phenotypes 25
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:218174 Hasan MZ, et al., Abnormal development of placenta in HtrA1-deficient mice. Dev Biol. 2015 Jan 1;397(1):89-102

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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