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Htra3
Gene Detail
Symbol

Name
ID
Htra3
HtrA serine peptidase 3
MGI:1925808
Synonyms
2210021K23Rik, 9530081K03Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 5
18.49 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:35652041-35679782 bp, - strand
From VEGA annotation of GRCm38

  27742 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12697  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HTRA3
Protein SuperFamily: serine protease, HTRA type
Gene Tree: Htra3

Human
homologs
HTRA3, HtrA serine peptidase 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 94031
neXtProt AC: NX_P83110

Human Synonyms: Prsp, Tasp

Human Chr (Location): 4p16.1; chr4:8269754-8307111 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Radiation induced(5) Targeted(3)
Genomic Mutations involving Htra3 (6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Mutations Annotated to Human Diseases (4)    Phenotype Images(4)
Interactions
Htra3 interacts with 162 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
cDNA source data(68)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase htra3 ; ZFIN htra3a    NEW 
Molecular
reagents
All nucleic(68) cDNA(68)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000024097 (Evidence)
Ensembl Gene Model ENSMUSG00000029096 (Evidence)
Entrez Gene 78558 (Evidence)
UniGene 274255
DFCI TC1579356, TC1596200, TC1585170
DoTS DT.94242945, DT.91596256, DT.492443, DT.101356522
NIA Mouse Gene Index U026114
EC 3.4.21.-
Consensus CDS Project CCDS19233.1, CCDS39071.1
International Mouse Phenotyping Consortium Status Htra3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024097 VEGA Gene Model | MGI Sequence Detail 27742 C57BL/6J ±  kb
transcript OTTMUST00000058943 VEGA | MGI Sequence Detail 2732 Not Applicable 
polypeptide OTTMUSP00000028630 VEGA | MGI Sequence Detail 459 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(287 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000867 Insulin-like growth factor-binding protein, IGFBP
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR002350 Kazal domain
InterPro IPR001478 PDZ domain
InterPro IPR001940 Peptidase S1C
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000031746 serine protease HTRA3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:218174 Hasan MZ, et al., Abnormal development of placenta in HtrA1-deficient mice. Dev Biol. 2015 Jan 1;397(1):89-102
All references(32)
Other
accession IDs
MGI:1921510

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory