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Htra3 Gene Detail
Summary
  • Symbol
    Htra3
  • Name
    HtrA serine peptidase 3
  • Synonyms
    2210021K23Rik, 9530081K03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925808
    NCBI Gene: 78558
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr5:35652023-35679782 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      27760 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 18.49 cM, cytoband B1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HTRA3, HtrA serine peptidase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HTRA3, HtrA serine peptidase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Prsp, Tasp
  • Links
    NCBI Gene ID: 94031
    neXtProt AC: NX_P83110
    UniProt: P83110

  • Chr Location
    4p16.1; chr4:8269757-8307111 (+)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotype references
  • All Mutations and Alleles
    12
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Radiation induced
    4
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    8 involving Htra3
  • Incidental Mutations
    Mutagenetix , APF , CvDC
  • Find Mice (IMSR)
    11 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    9
  • Tissues
    4
  • cDNA Data
    69
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024097 VEGA Gene Model | MGI Sequence Detail 27760 C57BL/6J ±  kb
transcript OTTMUST00000058943 VEGA | MGI Sequence Detail 2750 Not Applicable  
polypeptide OTTMUSP00000028630 VEGA | MGI Sequence Detail 459 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    287 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 69
    cDNA 69

    Microarray probesets 7
Other
Accession IDs
less
MGI:1921510
References
more
  • Summaries
    All 52
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 4
    Phenotypes 25
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:218174 Hasan MZ, et al., Abnormal development of placenta in HtrA1-deficient mice. Dev Biol. 2015 Jan 1;397(1):89-102
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/11/2018
MGI 6.12 		The Jackson Laboratory