Htra3
Gene Detail

Symbol

Name
ID

Htra3
HtrA serine peptidase 3
MGI:1925808

Synonyms

2210021K23Rik, 9530081K03Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 5
18.49 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:35652041-35679782 bp, - strand From VEGA annotation of GRCm38   27742 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:12697  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: serine protease, HTRA type
Gene Tree: Htra3

Human
homologs

Human Homolog		HTRA3, HtrA serine peptidase 3
NCBI Gene ID		94031
neXtProt AC		NX_P83110
Human Synonyms		Prsp, Tasp
Human Chr (Location)		4p16.1; chr4:8269760-8307111 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(9) : Chemically induced (ENU)(1) Radiation induced(5) Targeted(3)
Genomic Mutations involving Htra3 (6)
Incidental mutations (data from Mutagenetix , APF )
Mutations Annotated to Human Diseases (4)    Phenotype Images(4)

Interactions

Htra3 interacts with 162 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (16 annotations)

Process	negative regulation of BMP signaling pathway, negative regulation of transforming growth factor beta receptor signaling pathway, ...
Component	extracellular region
Function	catalytic activity, endopeptidase activity, ...

External Resources: FuncBase

Expression

cDNA source data(68)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(68) cDNA(68)
Microarray probesets(7)

Other database
links

VEGA Gene Model	OTTMUSG00000024097 (Evidence)
Ensembl Gene Model	ENSMUSG00000029096 (Evidence)
Entrez Gene	78558 (Evidence)
UniGene	274255
DFCI	TC1579356, TC1596200, TC1585170
DoTS	DT.94242945, DT.91596256, DT.492443, DT.101356522
NIA Mouse Gene Index	U026114
EC	3.4.21.-
Consensus CDS Project	CCDS19233.1, CCDS39071.1
International Mouse Knockout Project Status	Htra3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024097	VEGA Gene Model | MGI Sequence Detail	27742	C57BL/6J
transcript	OTTMUST00000058943	VEGA | MGI Sequence Detail	2732	Not Applicable
polypeptide	OTTMUSP00000028630	VEGA | MGI Sequence Detail	459	Not Applicable

All sequences(48) RefSeq(8) UniProt(3)

Polymorphisms

SNPs within 2kb(287 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000867	Insulin-like growth factor-binding protein, IGFBP
InterPro	IPR009030	Insulin-like growth factor binding protein, N-terminal
InterPro	IPR002350	Kazal domain
InterPro	IPR001478	PDZ domain
InterPro	IPR001940	Peptidase S1C
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000031746	serine protease HTRA3

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(31)

Other
accession IDs

MGI:1921510