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Htra3 Gene Detail
Summary
  • Symbol
    Htra3
  • Name
    HtrA serine peptidase 3
  • Synonyms
    2210021K23Rik, 9530081K03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925808
    NCBI Gene: 78558
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:35652023-35679782 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 18.49 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    287 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925808
 protein coding gene Chr5:35652023-35679813 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029482
 protein coding gene Chr5:33949132-33979888 (-)
A/J MGP_AJ_G0029449
 protein coding gene Chr5:32839384-32866738 (-)
AKR/J MGP_AKRJ_G0029398
 protein coding gene Chr5:34096274-34128902 (-)
BALB/cJ MGP_BALBcJ_G0029459
 protein coding gene Chr5:33352784-33380110 (-)
C3H/HeJ MGP_C3HHeJ_G0029181
 protein coding gene Chr5:34111098-34137506 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029913
 protein coding gene Chr5:35858790-35887961 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027150
 protein coding gene Chr5:30596314-30623520 (-)
CAST/EiJ MGP_CASTEiJ_G0028590
 protein coding gene Chr5:33202767-33235292 (-)
CBA/J MGP_CBAJ_G0029149
 protein coding gene Chr5:36699092-36732223 (-)
DBA/2J MGP_DBA2J_G0029297
 protein coding gene Chr5:32984547-33011631 (-)
FVB/NJ MGP_FVBNJ_G0029256
 protein coding gene Chr5:32449461-32477793 (-)
LP/J MGP_LPJ_G0029382
 protein coding gene Chr5:34377101-34403526 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029286
 protein coding gene Chr5:37493285-37520629 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029946
 protein coding gene Chr5:33594807-33623772 (-)
PWK/PhJ MGP_PWKPhJ_G0028315
 protein coding gene Chr5:32149433-32177521 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028146
 protein coding gene Chr5:33039528-33090876 (-)
WSB/EiJ MGP_WSBEiJ_G0028671
 protein coding gene Chr5:33656627-33685311 (-)



Homology
more
  • Human Ortholog
    HTRA3, HtrA serine peptidase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HTRA3, HtrA serine peptidase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Prsp, Tasp
  • Links
    NCBI Gene ID: 94031
    neXtProt AC: NX_P83110
    UniProt: P83110

  • Chr Location
    4p16.1; chr4:8269757-8307111 (+)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotype references
  • All Mutations and Alleles
    12
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Radiation induced
    4
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    8 involving Htra3
  • Incidental Mutations
    Mutagenetix , APF , CvDC
  • Find Mice (IMSR)
    11 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    640
  • Tissues
    4
  • cDNA Data
    69
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029096 Ensembl Gene Model | MGI Sequence Detail 27760 C57BL/6J ±  kb
transcript ENSMUST00000087629 Ensembl | MGI Sequence Detail 2750 Not Applicable  
polypeptide ENSMUSP00000084910 Ensembl | MGI Sequence Detail 459 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 69
    cDNA 69

    Microarray probesets 7
Other
Accession IDs
less
MGI:1921510
References
more
  • Summaries
    All 52
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 4
    Phenotypes 25
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:253036 Li Y, et al., Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood. Sci Rep. 2017 Jul 04;7(1):4627
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
07/07/2020
MGI 6.15 		The Jackson Laboratory