Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HTRA1
  • Mouse genes Htra1
  • Rat genes Htra1
  • Zfish genes htra1a,htra1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Htra1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	HTRA1	IPI	UniProtKB:Q92743	Human	PMID:21297635
Molecular Function	GO:0042802	identical protein binding	HTRA1	IPI	UniProtKB:Q92743	Human	PMID:22578544
Molecular Function	GO:0042802	identical protein binding	HTRA1	IPI	UniProtKB:Q92743	Human	PMID:28642151
Molecular Function	GO:0140677	molecular function activator activity	HTRA1	EXP		Human	PMID:21297635
Molecular Function	GO:0005515	protein binding	HTRA1	IPI	UniProtKB:P83105	Human	PMID:25002585
Molecular Function	GO:0005515	protein binding	HTRA1	IPI	UniProtKB:P10636-8	Human	PMID:26436840
Molecular Function	GO:0005515	protein binding	HTRA1	IPI	UniProtKB:P14174	Human	PMID:28726057
Molecular Function	GO:0005515	protein binding	HTRA1	IPI	UniProtKB:P07996:PRO_0000035842	Human	PMID:29572155
Molecular Function	GO:0005515	protein binding	Htra1	IPI	PR:P21275	Mouse	PMID:14973287
Molecular Function	GO:0005515	protein binding	Htra1	IPI	PR:P43027	Mouse	PMID:14973287
Molecular Function	GO:0008236	serine-type peptidase activity	Htra1	IDA		Mouse	MGI:MGI:3046453|PMID:15206957
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HTRA1	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HTRA1	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HTRA1	HDA		Human	PMID:23979707
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HTRA1	HDA		Human	PMID:27068509
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Htra1	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Htra1	IDA		Rat	PMID:22595117|RGD:7394756
Cellular Component	GO:0070062	extracellular exosome	HTRA1	HDA		Human	PMID:19199708
Cellular Component	GO:0005886	plasma membrane	HTRA1	IDA		Human	GO_REF:0000052
Biological Process	GO:0060718	chorionic trophoblast cell differentiation	Htra1	IMP		Mouse	PMID:25446274
Biological Process	GO:0097187	dentinogenesis	Htra1	IEP		Rat	PMID:22595117|RGD:7394756
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Htra1	IDA		Mouse	PMID:14973287
Biological Process	GO:0050687	negative regulation of defense response to virus	Htra1	IMP		Rat	PMID:15333144|RGD:2311622
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Htra1	IDA		Mouse	PMID:14973287
Biological Process	GO:0001890	placenta development	Htra1	IMP		Mouse	PMID:25446274
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Htra1	IMP		Rat	PMID:15333144|RGD:2311622
Biological Process	GO:0006508	proteolysis	Htra1	IDA		Mouse	MGI:MGI:3046453|PMID:15206957
Biological Process	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	htra1a	IMP	ZFIN:ZDB-MRPHLNO-121128-11	Zfish	PMID:22949504

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern