Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HTR4
  • Mouse genes Htr4
  • Rat genes Htr4
  • Zfish genes htr4,si:dkey-247m21.3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Htr4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	HTR4	IDA		Human	PMID:16102731
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	Htr4	IDA		Mouse	PMID:33299969
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	Htr4	IMP		Rat	PMID:10220570|RGD:729213
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	Htr4	IMP		Rat	PMID:7796807|RGD:729350
Molecular Function	GO:0005515	protein binding	HTR4	IPI	UniProtKB:O15354	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	HTR4	IPI	UniProtKB:O60269	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	Htr4	IPI	UniProtKB:P12931|UniProtKB:P34947	Mouse	MGI:MGI:5508582|PMID:19661922
Molecular Function	GO:0099589	serotonin receptor activity	HTR4	IDA		Human	PMID:33481771
Cellular Component	GO:0005737	cytoplasm	HTR4	IDA		Human	PMID:15925089
Cellular Component	GO:0016020	membrane	HTR4	IDA		Human	PMID:16102731
Cellular Component	GO:0005886	plasma membrane	Htr4	IDA		Mouse	PMID:33299969
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Htr4	IMP		Rat	PMID:7796807|RGD:729350
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Htr4	IDA		Mouse	PMID:33299969
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	Htr4	IMP		Rat	PMID:11986365|RGD:727368
Biological Process	GO:0120056	large intestinal transit	HTR4	IDA		Human	PMID:33481771
Biological Process	GO:0030277	maintenance of gastrointestinal epithelium	Htr4	IDA		Mouse	PMID:33299969
Biological Process	GO:0070254	mucus secretion	Htr4	IDA		Mouse	PMID:33299969

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern