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Htr4
Gene Detail
Symbol

Name
ID
Htr4
5 hydroxytryptamine (serotonin) receptor 4
MGI:109246
Synonyms
5-HT4, 5-HT4L
Feature Type
protein coding gene
Genetic Map
Chromosome 18
35.10 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:62324204-62467802 bp, + strand
From Ensembl annotation of GRCm38

  143599 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20243  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HTR4
Protein SuperFamily: 5-hydroxytryptamine receptor 4
Gene Tree: Htr4

Human
homologs
HTR4, 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3360
neXtProt AC: NX_Q13639

Human Synonyms: 5-HT4, 5-HT4R

Human Chr (Location): 5q31-q33; chr5:148451032-148654527 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit attenuated feeding behavior following stress and novelty and show a hypersensitivity to seizures.
 
Interactions
Htr4 interacts with 351 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (205)    Tissues (97)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 55
In situ reporter (knock in) 88
RT-PCR 62
cDNA source data(7)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase htr4    NEW 
Molecular
reagents
All nucleic(14) cDNA(7) Primer pair(5) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000026322 (Evidence)
Entrez Gene 15562 (Evidence)
DFCI TC1596778, TC1593690, TC1657514, TC1720050, TC1685285
NIA Mouse Gene Index U018804
Consensus CDS Project CCDS29291.1
International Mouse Phenotyping Consortium Status Htr4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026322 Ensembl Gene Model | MGI Sequence Detail 143599 C57BL/6J ±  kb
transcript ENSMUST00000027560 Ensembl | MGI Sequence Detail 4657 Not Applicable 
polypeptide ENSMUSP00000027560 Ensembl | MGI Sequence Detail 388 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(20) UniProt(5)
Polymorphisms
SNPs within 2kb(1159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001520 5-Hydroxytryptamine 4 receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001100 5-hydroxytryptamine receptor 4
References
(Earliest) J:39245 Gerald C, et al., The 5-HT4 receptor: molecular cloning and pharmacological characterization of two splice variants. EMBO J. 1995 Jun 15;14(12):2806-15
(Latest) J:218018 House JS, et al., Genetic variation in HTR4 and lung function: GWAS follow-up in mouse. FASEB J. 2015 Jan;29(1):323-35
All references(47)
Other
accession IDs
MGD-MRK-38291

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory