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Htr4
Gene Detail
Symbol

Name
ID
Htr4
5 hydroxytryptamine (serotonin) receptor 4
MGI:109246
Synonyms
5-HT4, 5-HT4L
Feature Type
protein coding gene
Genetic Map
Chromosome 18
35.10 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:62324204-62467802 bp, + strand
From NCBI annotation of GRCm38

  143599 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20243  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 5-hydroxytryptamine receptor 4
Gene Tree: Htr4

Human
homologs
Human Homolog HTR4, 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
NCBI Gene ID 3360
neXtProt AC  NX_Q13639
Human Synonyms  5-HT4, 5-HT4R
Human Chr (Location)  5q31-q33; chr5:148451032-148654527 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit attenuated feeding behavior following stress and novelty and show a hypersensitivity to seizures.
 
Interactions
Htr4 interacts with 351 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (207)    Tissues (99)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 57
In situ reporter (knock in) 88
RT-PCR 62
cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(7) Primer pair(5) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000026322 (Evidence)
Entrez Gene15562 (Evidence)
DFCITC1593690, TC1596778, TC1657514, TC1685285, TC1720050
NIA Mouse Gene IndexU018804
Consensus CDS ProjectCCDS29291.1
International Mouse Knockout Project StatusHtr4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15562 NCBI Gene Model | MGI Sequence Detail 143599 C57BL/6J ±  kb
transcript NM_008313 RefSeq | MGI Sequence Detail 4657 C57BL/6 
polypeptide P97288 UniProt | EBI | MGI Sequence Detail 388 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(20) UniProt(5)
Polymorphisms
SNPs within 2kb(1159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001520 5-Hydroxytryptamine 4 receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001100 5-hydroxytryptamine receptor 4
Graphical View of Protein Domain Structure
References
(Earliest) J:39245 Gerald C, et al., The 5-HT4 receptor: molecular cloning and pharmacological characterization of two splice variants. EMBO J. 1995 Jun 15;14(12):2806-15
(Latest) J:185068 Freret T, et al., Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice. Behav Brain Res. 2012 Apr 21;230(1):304-8
All references(47)
Other
accession IDs
MGD-MRK-38291

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory