Htr4
Gene Detail

Symbol Name ID

Htr4 5 hydroxytryptamine (serotonin) receptor 4 MGI:109246

Synonyms

5-HT4, 5-HT<4L>

Feature Type

protein coding gene

Genetic Map

Chromosome 18

35.10 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr18:62324204-62467802 bp, + strand From NCBI annotation of GRCm38   143599 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Htr4 ± 2 cM)

Protein SuperFamily: 5-hydroxytryptamine receptor 4
Gene Tree: Htr4

Human ortholog

HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled NCBI Gene ID 3360
Human Synonyms: 5-HT4, 5-HT4R
Human Chr5:147830595-148033739 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Homozygous mutant mice exhibit attenuated feeding behavior following stress and novelty and show a hypersensitivity to seizures.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	adenylate cyclase-activating G-protein coupled receptor signaling pathway, cognition, ...
Component	cytoplasm, endosome, ...
Function	calmodulin-dependent protein kinase activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (207)    Tissues (98)    Images (36)
Theiler Stages: 19, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	57
In situ reporter (knock in)	88
RT-PCR	62

cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(7) Primer pair(5) Other(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000026322 (Evidence)
Entrez Gene	15562 (Evidence)
DFCI	TC1593690, TC1596778, TC1657514, TC1685285, TC1720050
NIA Mouse Gene Index	U018804
Consensus CDS Project	CCDS29291.1
International Mouse Knockout Project Status	Htr4

Sequences

Length	Strain/Species
genomic	15562	NCBI Gene Model | MGI Sequence Detail	143599	C57BL/6J
transcript	NM_008313	RefSeq | MGI Sequence Detail	4657	C57BL/6
polypeptide	P97288	UniProt | EBI | MGI Sequence Detail	388	Not Applicable

All sequences(34) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(734 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001520	5-Hydroxytryptamine 4 receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001100	5-hydroxytryptamine receptor 4

Graphical View of Protein Domain Structure

References

(Earliest) J:39245 Gerald C, et al., The 5-HT4 receptor: molecular cloning and pharmacological characterization of two splice variants. EMBO J. 1995 Jun 15;14(12):2806-15
(Latest) J:185068 Freret T, et al., Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice. Behav Brain Res. 2012 Apr 21;230(1):304-8
All references(46)

Other accession IDs

MGD-MRK-38291