Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HPS1
  • Mouse genes Hps1
  • Rat genes Hps1
  • Zfish genes hps1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hps1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	HPS1	IDA		Human	PMID:23084991
Molecular Function	GO:0005515	protein binding	HPS1	IPI	UniProtKB:Q9NQG7	Human	PMID:12756248
Molecular Function	GO:0005515	protein binding	HPS1	IPI	UniProtKB:Q9NQG7	Human	PMID:20048159
Molecular Function	GO:0046983	protein dimerization activity	HPS1	IPI	UniProtKB:Q9NQG7	Human	PMID:12663659
Cellular Component	GO:0031085	BLOC-3 complex	HPS1	IPI		Human	PMID:20048159
Cellular Component	GO:0031085	BLOC-3 complex	HPS1	IPI	UniProtKB:Q9NQG7	Human	PMID:12756248
Cellular Component	GO:0031085	BLOC-3 complex	HPS1	IPI	UniProtKB:Q9NQG7	Human	PMID:20048159
Cellular Component	GO:0031085	BLOC-3 complex	HPS1	IPI	UniProtKB:Q9NQG7	Human	PMID:23084991
Cellular Component	GO:0005737	cytoplasm	HPS1	IDA		Human	PMID:12756248
Cellular Component	GO:0031410	cytoplasmic vesicle	HPS1	IDA		Human	PMID:11836498
Biological Process	GO:0007596	blood coagulation	Hps1	IMP	MGI:MGI:1856712	Mouse	PMID:6696991
Biological Process	GO:0000902	cell morphogenesis	Hps1	IGI	MGI:MGI:1333879	Mouse	PMID:12777251
Biological Process	GO:0048069	eye pigmentation	Hps1	IMP		Mouse	PMID:21052544
Biological Process	GO:0010467	gene expression	Hps1	IMP		Mouse	PMID:31272455
Biological Process	GO:0006954	inflammatory response	Hps1	IGI	MGI:MGI:2177763	Mouse	PMID:12777251
Biological Process	GO:0006882	intracellular zinc ion homeostasis	Hps1	IMP		Mouse	PMID:30786955
Biological Process	GO:0030324	lung development	Hps1	IGI	MGI:MGI:1333879	Mouse	PMID:12777251
Biological Process	GO:0060425	lung morphogenesis	Hps1	IGI	MGI:MGI:1333879	Mouse	PMID:12777251
Biological Process	GO:0007040	lysosome organization	Hps1	IMP		Mouse	PMID:30786955
Biological Process	GO:0030318	melanocyte differentiation	Hps1	IMP	MGI:MGI:1856712	Mouse	PMID:11836498
Biological Process	GO:1903232	melanosome assembly	HPS1	IDA		Human	PMID:23084991
Biological Process	GO:0006996	organelle organization	Hps1	IMP	MGI:MGI:1856712	Mouse	PMID:11836498
Biological Process	GO:0043473	pigmentation	Hps1	IMP	MGI:MGI:1856712	Mouse	PMID:2379821
Biological Process	GO:0043473	pigmentation	Hps1	IMP	MGI:MGI:1856712	Mouse	PMID:7089489
Biological Process	GO:0032816	positive regulation of natural killer cell activation	Hps1	IMP	MGI:MGI:1856712	Mouse	PMID:7089489
Biological Process	GO:0003016	respiratory system process	Hps1	IGI	MGI:MGI:2177763	Mouse	PMID:12777251
Biological Process	GO:0060041	retina development in camera-type eye	Hps1	IMP		Mouse	PMID:21052544
Biological Process	GO:0033299	secretion of lysosomal enzymes	Hps1	IMP	MGI:MGI:1856712	Mouse	PMID:7089489
Biological Process	GO:0007338	single fertilization	Hps1	IMP		Mouse	PMID:30786955
Biological Process	GO:0007283	spermatogenesis	Hps1	IMP		Mouse	PMID:30786955

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern