Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HLX
  • Mouse genes Hlx
  • Rat genes Hlx
  • Zfish genes hlx1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hlx

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	HLX	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HLX	IPI	UniProtKB:O75593	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HLX	IPI	UniProtKB:P0C7T5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HLX	IPI	UniProtKB:P86480	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HLX	IPI	UniProtKB:Q17RB8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HLX	IPI	UniProtKB:Q86UW9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HLX	IPI	UniProtKB:Q9BRT3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HLX	IPI	UniProtKB:Q9NWQ9	Human	PMID:32296183
Molecular Function	GO:0043565	sequence-specific DNA binding	HLX	IDA		Human	PMID:9073066
Biological Process	GO:0048513	animal organ development	Hlx	IMP	MGI:MGI:2182089	Mouse	PMID:8557196
Biological Process	GO:0008283	cell population proliferation	Hlx	IMP	MGI:MGI:2182089	Mouse	PMID:8557196
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	Hlx	IMP	MGI:MGI:2182089	Mouse	PMID:8557196
Biological Process	GO:0048484	enteric nervous system development	Hlx	IMP	MGI:MGI:2182089	Mouse	PMID:16854219
Biological Process	GO:0050673	epithelial cell proliferation	Hlx	IMP	MGI:MGI:2182089	Mouse	PMID:8557196
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	hlx1	IMP	ZFIN:ZDB-GENO-190509-4	Zfish	PMID:30082823
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	hlx1	IMP	ZFIN:ZDB-MRPHLNO-091020-3	Zfish	PMID:30082823
Biological Process	GO:0001889	liver development	Hlx	IMP	MGI:MGI:2182089	Mouse	PMID:8557196
Biological Process	GO:0045629	negative regulation of T-helper 2 cell differentiation	Hlx	IGI	MGI:MGI:105367	Mouse	PMID:16424184
Biological Process	GO:0045629	negative regulation of T-helper 2 cell differentiation	Hlx	IMP	MGI:MGI:2182089	Mouse	PMID:16424184
Biological Process	GO:0035265	organ growth	Hlx	IMP	MGI:MGI:2182089	Mouse	PMID:8557196
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Hlx	IMP	MGI:MGI:2182089	Mouse	PMID:8557196
Biological Process	GO:0046622	positive regulation of organ growth	Hlx	IMP	MGI:MGI:2182089	Mouse	PMID:8557196
Biological Process	GO:0045627	positive regulation of T-helper 1 cell differentiation	Hlx	IGI	MGI:MGI:105367	Mouse	PMID:16424184
Biological Process	GO:0045627	positive regulation of T-helper 1 cell differentiation	Hlx	IMP	MGI:MGI:2182089	Mouse	PMID:16424184
Biological Process	GO:0007519	skeletal muscle tissue development	Hlx	IMP	MGI:MGI:2182089	Mouse	PMID:8557196
Biological Process	GO:0002040	sprouting angiogenesis	hlx1	IMP	ZFIN:ZDB-MRPHLNO-091020-3,ZFIN:ZDB-MRPHLNO-121221-1	Zfish	PMID:22921365
Biological Process	GO:0045063	T-helper 1 cell differentiation	Hlx	IGI	MGI:MGI:105367	Mouse	PMID:16424184
Biological Process	GO:0045063	T-helper 1 cell differentiation	Hlx	IMP	MGI:MGI:2182089	Mouse	PMID:16424184
Biological Process	GO:0045064	T-helper 2 cell differentiation	Hlx	IGI	MGI:MGI:105367	Mouse	PMID:16424184
Biological Process	GO:0045064	T-helper 2 cell differentiation	Hlx	IMP	MGI:MGI:2182089	Mouse	PMID:16424184

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern