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Hlx
Gene Detail
 Symbol
Name
ID
Hlx
H2.0-like homeobox
MGI:96109
Synonyms Hlx1
Feature Type protein coding gene
Genetic Map
Chromosome 1
88.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:184727140-184732619 bp, - strand
From VEGA annotation of GRCm38

  5480 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7363  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Hlx

Human
homologs
Human Homolog HLX, H2.0-like homeobox
NCBI Gene ID 3142
neXtProt AC  NX_Q14774
Human Synonyms  HB24, HLX1
Human Chr (Location)  1q41; chr1:220879401-220885059 (+)  GRCh38
Alleles
and
phenotypes
All alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disrputions in this gene die as embryos as a result of defective organogenesis and fetal hematopoiesis.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell differentiation, embryonic digestive tract morphogenesis, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (80)    Tissues (61)    Images (4)
Theiler Stages: 12, 13, 15, 17, 19, 20, 22, 23, 24, 28
Assay TypeResults
RNA in situ 37
Northern blot 3
RNase protection 40
cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(22) Genomic(3) cDNA(19)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037282 (Evidence)
Ensembl Gene ModelENSMUSG00000039377 (Evidence)
Entrez Gene15284 (Evidence)
UniGene1347
DFCITC1583803
DoTSDT.40184715
NIA Mouse Gene IndexU022167
Consensus CDS ProjectCCDS15593.1
International Mouse Knockout Project StatusHlx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037282 VEGA Gene Model | MGI Sequence Detail 5480 C57BL/6J ±  kb
transcript OTTMUST00000096185 VEGA | MGI Sequence Detail 2278 Not Applicable 
polypeptide OTTMUSP00000053709 VEGA | MGI Sequence Detail 476 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(5)
Polymorphisms RFLP(3) : SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008620 H2.0-like homeobox protein
References (Earliest) J:2276 Murtha MT, et al., Detection of homeobox genes in development and evolution. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10711-5
(Latest) J:188177 Shotorbani SS, et al., Over-expression of Hlx homeobox gene in DC2.4 dendritic cell enhances its maturation and antigen presentation. Cell Immunol. 2012 Jan-Feb;275(1-2):61-8
All references(46)
Other
accession IDs
MGD-MRK-10743

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory