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Hlx Gene Detail
Summary
  • Symbol
    Hlx
  • Name
    H2.0-like homeobox
  • Synonyms
    Hlx1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96109
    NCBI Gene: 15284
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:184459340-184464690 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 88.97 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96109
protein coding gene Chr1:184459337-184464816 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016908
protein coding gene Chr1:191402501-191408855 (-)
A/J MGP_AJ_G0016887
protein coding gene Chr1:183604534-183609971 (-)
AKR/J MGP_AKRJ_G0016852
protein coding gene Chr1:189009059-189014440 (-)
BALB/cJ MGP_BALBcJ_G0016845
protein coding gene Chr1:184234956-184244123 (-)
C3H/HeJ MGP_C3HHeJ_G0016669
protein coding gene Chr1:189857084-189862559 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017308
protein coding gene Chr1:197529411-197535723 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015015
protein coding gene Chr1:174601805-174607516 (-)
CAST/EiJ MGP_CASTEiJ_G0016252
protein coding gene Chr1:189275290-189281817 (-)
CBA/J MGP_CBAJ_G0016643
protein coding gene Chr1:204904175-204910715 (-)
DBA/2J MGP_DBA2J_G0016749
protein coding gene Chr1:182365768-182371256 (-)
FVB/NJ MGP_FVBNJ_G0016745
protein coding gene Chr1:180465015-180470423 (-)
LP/J MGP_LPJ_G0016824
protein coding gene Chr1:192571633-192577197 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016777
protein coding gene Chr1:211803569-211813888 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017345
protein coding gene Chr1:188866641-188872199 (-)
PWK/PhJ MGP_PWKPhJ_G0016039
protein coding gene Chr1:181561236-181566758 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015815
protein coding gene Chr1:187836782-187842144 (-)
WSB/EiJ MGP_WSBEiJ_G0016314
protein coding gene Chr1:189041005-189047367 (-)



Homology
more
  • Human Ortholog
    HLX, H2.0 like homeobox
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLX, H2.0 like homeobox
  • Synonyms
    HB24, HLX1
  • Links
    NCBI Gene ID: 3142
    neXtProt AC: NX_Q14774
    UniProt: Q14774

  • Chr Location
    1q41; chr1:220879431-220885059 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 3 genetic backgrounds
    1 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disrputions in this gene die as embryos as a result of defective organogenesis and fetal hematopoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15284 NCBI Gene Model | MGI Sequence Detail 5351 C57BL/6J ±  kb
    transcript NM_008250 RefSeq | MGI Sequence Detail 2171 ZRU/MplStud  
    polypeptide Q61670 UniProt | EBI | MGI Sequence Detail 476 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 3
      cDNA 22
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10743
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 12
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:2276 Murtha MT, et al., Detection of homeobox genes in development and evolution. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10711-5
    • Latest
      J:300359 Zhang H, et al., An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets. Cell Rep. 2020 Nov 24;33(8):108433

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory