Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Hk1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes HK1
- Mouse genes Hk1
- Rat genes Hk1
- Zfish genes hk1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Hk1	IDA		Rat	PMID:15562563\|RGD:2302669
Molecular Function	GO:0008865	fructokinase activity	Hk1	IDA		Rat	PMID:13211595\|RGD:14695069
Molecular Function	GO:0008865	fructokinase activity	Hk1	IDA		Rat	PMID:5871820\|RGD:14695073
Molecular Function	GO:0004340	glucokinase activity	Hk1	IDA		Mouse	PMID:18509164
Molecular Function	GO:0004340	glucokinase activity	Hk1	IDA		Rat	PMID:13211595\|RGD:14695069
Molecular Function	GO:0004340	glucokinase activity	Hk1	IDA		Rat	PMID:15574336\|RGD:1358232
Molecular Function	GO:0004340	glucokinase activity	Hk1	IDA		Rat	PMID:5871820\|RGD:14695073
Molecular Function	GO:0005536	glucose binding	Hk1	IDA		Rat	PMID:15562563\|RGD:2302669
Molecular Function	GO:0005536	glucose binding	Hk1	IDA		Rat	PMID:15574336\|RGD:1358232
Molecular Function	GO:0005536	glucose binding	Hk1	IDA		Rat	PMID:9665168\|RGD:2302668
Molecular Function	GO:0004396	hexokinase activity	HK1	IMP		Human	PMID:27374331
Molecular Function	GO:0004396	hexokinase activity	Hk1	IMP		Mouse	MGI:MGI:5790524\|PMID:27374331
Molecular Function	GO:0004396	hexokinase activity	Hk1	IDA		Mouse	PMID:15155459
Molecular Function	GO:0004396	hexokinase activity	Hk1	IDA		Mouse	PMID:18165236
Molecular Function	GO:0004396	hexokinase activity	Hk1	IDA		Rat	PMID:15138155\|RGD:1582633
Molecular Function	GO:0004396	hexokinase activity	Hk1	IDA		Rat	PMID:15562563\|RGD:2302669
Molecular Function	GO:0004396	hexokinase activity	Hk1	IDA		Rat	PMID:2457393\|RGD:10047157
Molecular Function	GO:0004396	hexokinase activity	Hk1	IDA		Rat	PMID:4353083\|RGD:2302851
Molecular Function	GO:0042802	identical protein binding	Hk1	IPI	RGD:2796	Rat	PMID:9665168\|RGD:2302668
Molecular Function	GO:0019158	mannokinase activity	Hk1	IDA		Rat	PMID:13211595\|RGD:14695069
Molecular Function	GO:0042834	peptidoglycan binding	HK1	IDA		Human	PMID:27374331
Molecular Function	GO:0042834	peptidoglycan binding	Hk1	IDA		Mouse	MGI:MGI:5790524\|PMID:27374331
Molecular Function	GO:0005515	protein binding	HK1	IPI	UniProtKB:P21796	Human	PMID:22304920
Molecular Function	GO:0005515	protein binding	HK1	IPI	UniProtKB:P05480	Human	PMID:28054552
Molecular Function	GO:0005515	protein binding	HK1	IPI	UniProtKB:P12931	Human	PMID:28054552
Molecular Function	GO:0005515	protein binding	Hk1	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:0005515	protein binding	Hk1	IPI	PR:P47857	Mouse	PMID:19889946
Molecular Function	GO:0005515	protein binding	Hk1	IPI	RGD:2280	Rat	PMID:16419038\|RGD:1601538
Molecular Function	GO:0005515	protein binding	Hk1	IPI	RGD:3704	Rat	PMID:16419038\|RGD:1601538
Molecular Function	GO:0005515	protein binding	Hk1	IPI	RGD:3706	Rat	PMID:16419038\|RGD:1601538
Molecular Function	GO:0004672	protein kinase activity	Hk1	IDA		Rat	PMID:7531990\|RGD:1601557
Molecular Function	GO:0044877	protein-containing complex binding	Hk1	IDA		Rat	PMID:14561215\|RGD:2302670
Cellular Component	GO:0005901	caveola	Hk1	IDA		Rat	PMID:16419038\|RGD:1601538
Cellular Component	GO:0005829	cytosol	Hk1	IDA		Mouse	MGI:MGI:5790524\|PMID:27374331
Cellular Component	GO:0005829	cytosol	Hk1	IDA		Mouse	PMID:12420306
Cellular Component	GO:0005829	cytosol	Hk1	IDA		Rat	PMID:15562563\|RGD:2302669
Cellular Component	GO:0045121	membrane raft	Hk1	IDA		Mouse	PMID:19144954
Cellular Component	GO:0005739	mitochondrion	HK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	HK1	HDA		Human	PMID:20833797
Cellular Component	GO:0005739	mitochondrion	Hk1	IDA		Mouse	MGI:MGI:5790524\|PMID:27374331
Cellular Component	GO:0005739	mitochondrion	Hk1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Hk1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Hk1	IDA		Rat	PMID:15562563\|RGD:2302669
Cellular Component	GO:0005739	mitochondrion	Hk1	IDA		Rat	PMID:15574336\|RGD:1358232
Cellular Component	GO:0005739	mitochondrion	Hk1	IDA		Rat	PMID:21410437\|RGD:7349317
Cellular Component	GO:0005739	mitochondrion	Hk1	IDA		Rat	PMID:2457393\|RGD:10047157
Cellular Component	GO:0032991	protein-containing complex	Hk1	IDA		Rat	PMID:9459579\|RGD:4891003
Biological Process	GO:0061621	canonical glycolysis	Hk1	IDA		Mouse	PMID:4275392
Biological Process	GO:0046835	carbohydrate phosphorylation	HK1	IMP		Human	PMID:27374331
Biological Process	GO:0046835	carbohydrate phosphorylation	Hk1	IMP		Mouse	MGI:MGI:5790524\|PMID:27374331
Biological Process	GO:0046835	carbohydrate phosphorylation	Hk1	IDA		Mouse	MGI:MGI:3775883\|PMID:18165236
Biological Process	GO:0046835	carbohydrate phosphorylation	Hk1	IDA		Rat	PMID:14561215\|RGD:2302670
Biological Process	GO:0046835	carbohydrate phosphorylation	Hk1	IDA		Rat	PMID:15574336\|RGD:1358232
Biological Process	GO:0072655	establishment of protein localization to mitochondrion	HK1	IMP		Human	PMID:23962723
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Hk1	IDA		Rat	PMID:13211595\|RGD:14695069
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Hk1	IDA		Rat	PMID:5871820\|RGD:14695073
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	Hk1	IDA		Rat	PMID:13211595\|RGD:14695069
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	Hk1	IDA		Rat	PMID:5871820\|RGD:14695073
Biological Process	GO:0006096	glycolytic process	Hk1	IDA		Rat	PMID:15574336\|RGD:1358232
Biological Process	GO:0006096	glycolytic process	Hk1	IDA		Rat	PMID:4353083\|RGD:2302851
Biological Process	GO:0072656	maintenance of protein location in mitochondrion	HK1	IMP		Human	PMID:23962723
Biological Process	GO:0006013	mannose metabolic process	Hk1	IDA		Rat	PMID:13211595\|RGD:14695069
Biological Process	GO:0043066	negative regulation of apoptotic process	Hk1	IMP		Rat	PMID:15574336\|RGD:1358232
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Hk1	IDA		Rat	PMID:7531990\|RGD:1601557
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	Hk1	IDA		Rat	PMID:7531990\|RGD:1601557
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Hk1	IDA		Rat	PMID:7531990\|RGD:1601557
Biological Process	GO:0002720	positive regulation of cytokine production involved in immune response	Hk1	IDA		Mouse	MGI:MGI:5790524\|PMID:27374331
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Hk1	IDA		Mouse	MGI:MGI:5790524\|PMID:27374331
Biological Process	GO:0046777	protein autophosphorylation	Hk1	IDA		Rat	PMID:2059200\|RGD:1601562
Biological Process	GO:0046777	protein autophosphorylation	Hk1	IDA		Rat	PMID:7531990\|RGD:1601557
Biological Process	GO:0006468	protein phosphorylation	Hk1	IDA		Rat	PMID:2059200\|RGD:1601562
Biological Process	GO:0010359	regulation of anion channel activity	Hk1	IDA		Rat	PMID:14561215\|RGD:2302670
Biological Process	GO:0009741	response to brassinosteroid	Hk1	IEP		Rat	PMID:20570616\|RGD:11353964
Biological Process	GO:0001666	response to hypoxia	Hk1	IEP		Rat	PMID:29676955\|RGD:13703029
Biological Process	GO:0002931	response to ischemia	Hk1	IDA		Rat	PMID:21410437\|RGD:7349317
Biological Process	GO:1901986	response to ketamine	Hk1	IEP		Rat	PMID:22605548\|RGD:11353962

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.