Hk1
Gene Detail

Symbol Name ID

Hk1 hexokinase 1 MGI:96103

Synonyms

Hk-1, Hk1-s, mHk1-s

Feature Type

protein coding gene

Genetic Map

Chromosome 10

32.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr10:62268855-62379908 bp, - strand From VEGA annotation of GRCm38   111054 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:100530  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: hexokinase I
Gene Tree: Hk1

Human homologs

Human Homolog		HK1, hexokinase 1
NCBI Gene ID		3098
neXtProt AC		NX_P19367
Human Synonyms		HK1-ta, HK1-tb, HK1-tc, HKI, HXK1
Human Chr (Location)		10q22; chr10:71029756-71161638 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HK1

Alleles and phenotypes

All alleles(12) : Gene trapped(11) Spontaneous(1)
 

Homozygous mutant mice exhibit hemolytic anemia with extensive tissue iron deposition and reticulocytosis and female infertility.

 
Human Diseases Modeled Using Mouse Hk1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	carbohydrate metabolic process, carbohydrate phosphorylation, ...
Component	cytosol, membrane, ...
Function	catalytic activity, fructokinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (235)    Tissues (104)    Images (31)
Theiler Stages: 17, 19, 22, 24, 28

Assay Type	Results
RNA in situ	225
Northern blot	3
Western blot	5
RT-PCR	2

cDNA source data(201)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(205) cDNA(202) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000034151 (Evidence)
Ensembl Gene Model	ENSMUSG00000037012 (Evidence)
Entrez Gene	15275 (Evidence)
UniGene	196605
DFCI	TC1572234, TC1591776, TC1615139, TC1623646, TC1677199
DoTS	DT.101404275, DT.101737390, DT.103579889, DT.91585472, DT.94349568, DT.94355335, DT.97353692, DT.97353849
NIA Mouse Gene Index	U031846
EC	2.7.1.1
Consensus CDS Project	CCDS48577.1, CCDS48578.1
International Mouse Knockout Project Status	Hk1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034151	VEGA Gene Model | MGI Sequence Detail	111054	C57BL/6J
transcript	OTTMUST00000086504	VEGA | MGI Sequence Detail	3851	Not Applicable
polypeptide	OTTMUSP00000046850	VEGA | MGI Sequence Detail	945	Not Applicable

All sequences(148) RefSeq(4) UniProt(13)

Polymorphisms

RFLP(5) : SNPs(301 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001312	Hexokinase
InterPro	IPR019807	Hexokinase, conserved site
InterPro	IPR022673	Hexokinase, C-terminal
InterPro	IPR022672	Hexokinase, N-terminal
Protein Ontology	PR:000008608	hexokinase-1

References

(Earliest) J:5994 Lalley PA, et al., Conservation of autosomal gene synteny groups in mouse and man. Nature. 1978 Jul 13;274(5667):160-3
(Latest) J:186869 Gall JM, et al., Hexokinase regulates Bax-mediated mitochondrial membrane injury following ischemic stress. Kidney Int. 2011 Jun;79(11):1207-16
All references(71)

Other accession IDs

MGD-MRK-10735, MGD-MRK-10736, MGI:1891296, MGI:3035452