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Hk1 Gene Detail
Summary
  • Symbol
    Hk1
  • Name
    hexokinase 1
  • Synonyms
    Hk-1, Hk1-s, mHk1-s
  • Feature Type
    protein coding gene
  • IDs
    MGI:96103
    NCBI Gene: 15275
  • Gene Overview
    MyGene.info: HK1
Location & Maps
more
  • Sequence Map
    Chr10:62268855-62379908 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      111054 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.37 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    HK1, hexokinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HK1, hexokinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hexokinase, HK, HK1-ta, HK1-tb, HK1-tc, HKD, HKI, HMSNR, HXK1
  • Links
    NCBI Gene ID: 3098
    neXtProt AC: NX_P19367

  • Chr Location
    10q22.1; chr10:69269984-69401882 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Hk1 mouse models; 2 with human HK1 associations

Human Disease Mouse Models
       Hemolytic Anemia, Nonspherocytic, Due to Hexokinase Deficiency   OMIM: 235700 View 1 model
       Neuropathy, Hereditary Motor and Sensory, Russe Type; HMSNR   OMIM: 605285
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Radiation induced
    1
  • Spontaneous
    1
  • Genomic Mutations
    2 involving Hk1
  • Incidental Mutations
Homozygous mutant mice exhibit hemolytic anemia with extensive tissue iron deposition and reticulocytosis and female infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034151 VEGA Gene Model | MGI Sequence Detail 111054 C57BL/6J ±  kb
transcript OTTMUST00000086504 VEGA | MGI Sequence Detail 3851 Not Applicable  
polypeptide OTTMUSP00000046850 VEGA | MGI Sequence Detail 945 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    400 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 206
    cDNA 203
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10735, MGD-MRK-10736, MGI:1891296, MGI:3035452
References
more
  • Summaries
    All 70
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 17
    Phenotypes 10
  • Earliest
    J:5994 Lalley PA, et al., Conservation of autosomal gene synteny groups in mouse and man. Nature. 1978 Jul 13;274(5667):160-3
  • Latest
    J:233841 Inoue M, et al., Isolation and Characterization of Fetal Leydig Progenitor Cells of Male Mice. Endocrinology. 2016 Mar;157(3):1222-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory