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Hk1
Gene Detail
 Symbol
Name
ID
Hk1
hexokinase 1
MGI:96103
Synonyms Hk-1, Hk1-s, mHk1-s
Feature Type protein coding gene
Genetic Map
Chromosome 10
32.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr10:62268855-62379908 bp, - strand
From VEGA annotation of GRCm38

  111054 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:100530  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: hexokinase I
Gene Tree: Hk1

Human
homologs
Human Homolog HK1, hexokinase 1
NCBI Gene ID 3098
neXtProt AC  NX_P19367
Human Synonyms  HK1-ta, HK1-tb, HK1-tc, HKD, HKI, HMSNR, HXK1
Human Chr (Location)  10q22; chr10:69269984-69401882 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human HK1
Alleles
and
phenotypes
All alleles(12) : Gene trapped(11) Spontaneous(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit hemolytic anemia with extensive tissue iron deposition and reticulocytosis and female infertility.
 
Human Diseases Modeled Using Mouse Hk1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process canonical glycolysis, carbohydrate metabolic process, ...
Component caveola, cilium, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (235)    Tissues (104)    Images (31)
Theiler Stages: 17, 19, 22, 24, 28
Assay TypeResults
RNA in situ 225
Northern blot 3
Western blot 5
RT-PCR 2
cDNA source data(202)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(206) cDNA(203) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034151 (Evidence)
Ensembl Gene ModelENSMUSG00000037012 (Evidence)
Entrez Gene15275 (Evidence)
UniGene196605
DFCITC1572234, TC1591776, TC1615139, TC1623646, TC1677199
DoTSDT.101404275, DT.101737390, DT.103579889, DT.91585472, DT.94349568, DT.94355335, DT.97353692, DT.97353849
NIA Mouse Gene IndexU031846
EC2.7.1.1
Consensus CDS ProjectCCDS48577.1, CCDS48578.1
International Mouse Knockout Project StatusHk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034151 VEGA Gene Model | MGI Sequence Detail 111054 C57BL/6J ±  kb
transcript OTTMUST00000086504 VEGA | MGI Sequence Detail 3851 Not Applicable 
polypeptide OTTMUSP00000046850 VEGA | MGI Sequence Detail 945 Not Applicable 

For the selected sequences
All sequences(160) RefSeq(16) UniProt(13)
Polymorphisms RFLP(5) : SNPs within 2kb(400 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001312 Hexokinase
InterPro IPR019807 Hexokinase, conserved site
InterPro IPR022673 Hexokinase, C-terminal
InterPro IPR022672 Hexokinase, N-terminal
Protein Ontology PR:000008608 hexokinase-1
References (Earliest) J:5994 Lalley PA, et al., Conservation of autosomal gene synteny groups in mouse and man. Nature. 1978 Jul 13;274(5667):160-3
(Latest) J:199136 Rog-Zielinska EA, et al., Glucocorticoid receptor is required for foetal heart maturation. Hum Mol Genet. 2013 Aug 15;22(16):3269-82
All references(76)
Other
accession IDs
MGD-MRK-10735, MGD-MRK-10736, MGI:1891296, MGI:3035452

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory