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Hk1
Gene Detail
Symbol

Name
ID
Hk1
hexokinase 1
MGI:96103
Synonyms
Hk-1, Hk1-s, mHk1-s
Feature Type
protein coding gene
Genetic Map
Chromosome 10
32.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr10:62268855-62379908 bp, - strand
From VEGA annotation of GRCm38

  111054 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:100530  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HK1
Protein SuperFamily: hexokinase I
Gene Tree: Hk1

Human
homologs
HK1, hexokinase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3098
neXtProt AC: NX_P19367

Human Synonyms: HK1-ta, HK1-tb, HK1-tc, HKD, HKI, HMSNR, HXK1

Human Chr (Location): 10q22; chr10:69269984-69401882 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human HK1

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(11) Spontaneous(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice exhibit hemolytic anemia with extensive tissue iron deposition and reticulocytosis and female infertility.
 
Human Diseases Modeled in Mice Using Hk1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Hk1 interacts with 141 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process canonical glycolysis, carbohydrate metabolic process, ...
Component caveola, cell, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (235)    Tissues (105)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 225
Northern blot 3
Western blot 5
RT-PCR 2
cDNA source data(202)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hk1 ; ZFIN hk1    NEW 
Molecular
reagents
All nucleic(206) cDNA(203) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000034151 (Evidence)
Ensembl Gene Model ENSMUSG00000037012 (Evidence)
Entrez Gene 15275 (Evidence)
UniGene 196605
DFCI TC1572234, TC1591776, TC1615139, TC1623646, TC1677199
DoTS DT.101404275, DT.101737390, DT.103579889, DT.91585472, DT.94349568, DT.94355335, DT.97353692, DT.97353849
NIA Mouse Gene Index U031846
EC 2.7.1.1
Consensus CDS Project CCDS48577.1, CCDS48578.1
International Mouse Phenotyping Consortium Status Hk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034151 VEGA Gene Model | MGI Sequence Detail 111054 C57BL/6J ±  kb
transcript OTTMUST00000086504 VEGA | MGI Sequence Detail 3851 Not Applicable 
polypeptide OTTMUSP00000046850 VEGA | MGI Sequence Detail 945 Not Applicable 

For the selected sequences
All sequences(164) RefSeq(16) UniProt(13)
Polymorphisms
RFLP(5) : SNPs within 2kb(400 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001312 Hexokinase
InterPro IPR019807 Hexokinase, conserved site
InterPro IPR022673 Hexokinase, C-terminal
InterPro IPR022672 Hexokinase, N-terminal
Protein Ontology PR:000008608 hexokinase-1
References
(Earliest) J:5994 Lalley PA, et al., Conservation of autosomal gene synteny groups in mouse and man. Nature. 1978 Jul 13;274(5667):160-3
(Latest) J:213639 Smith JA, et al., Renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury. Am J Physiol Renal Physiol. 2014 Aug 15;307(4):F435-44
All references(72)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10735, MGD-MRK-10736, MGI:1891296, MGI:3035452

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory