Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HBEGF
  • Mouse genes Hbegf
  • Rat genes Hbegf
  • Zfish genes hbegfa,hbegfb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hbegf

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005154	epidermal growth factor receptor binding	Hbegf	IDA		Mouse	MGI:MGI:3690187|PMID:1840698
Molecular Function	GO:0005154	epidermal growth factor receptor binding	Hbegf	IMP		Rat	PMID:15486316|RGD:1581908
Molecular Function	GO:0008083	growth factor activity	HBEGF	IDA		Human	PMID:12070119
Molecular Function	GO:0008083	growth factor activity	Hbegf	IDA		Mouse	MGI:MGI:3690187|PMID:1840698
Molecular Function	GO:0008083	growth factor activity	Hbegf	IMP		Rat	PMID:15486316|RGD:1581908
Molecular Function	GO:0008201	heparin binding	HBEGF	IMP		Human	PMID:8300582
Molecular Function	GO:0008201	heparin binding	Hbegf	IDA		Mouse	MGI:MGI:3690187|PMID:1840698
Molecular Function	GO:0005515	protein binding	HBEGF	IPI	UniProtKB:P00533	Human	PMID:28988771
Molecular Function	GO:0005515	protein binding	HBEGF	IPI	UniProtKB:P06396	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HBEGF	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HBEGF	IPI	UniProtKB:P00533	Human	PMID:9135143
Molecular Function	GO:0005515	protein binding	HBEGF	IPI	UniProtKB:Q15303	Human	PMID:9135143
Molecular Function	GO:0048018	receptor ligand activity	HBEGF	IDA		Human	PMID:8702723
Molecular Function	GO:0048018	receptor ligand activity	Hbegf	IMP	MGI:MGI:2665039	Mouse	PMID:21946538
Molecular Function	GO:0048018	receptor ligand activity	Hbegf	IMP	MGI:MGI:2655703	Mouse	PMID:16357442
Molecular Function	GO:0048018	receptor ligand activity	Hbegf	IMP	MGI:MGI:2655703	Mouse	PMID:12621152
Molecular Function	GO:0048018	receptor ligand activity	Hbegf	IDA		Mouse	PMID:12621152
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	HBEGF	IDA		Human	PMID:8702723
Cellular Component	GO:0009986	cell surface	HBEGF	IDA		Human	PMID:12743035
Cellular Component	GO:0005615	extracellular space	HBEGF	IDA		Human	PMID:8702723
Cellular Component	GO:0005615	extracellular space	HBEGF	IDA		Human	PMID:12743035
Cellular Component	GO:0005615	extracellular space	Hbegf	IDA		Mouse	MGI:MGI:1326990|PMID:9857183
Cellular Component	GO:0005615	extracellular space	Hbegf	IDA		Mouse	PMID:21946538
Cellular Component	GO:0005615	extracellular space	Hbegf	IDA		Mouse	PMID:12621152
Cellular Component	GO:0005886	plasma membrane	Hbegf	IDA		Mouse	MGI:MGI:1326990|PMID:9857183
Biological Process	GO:0060326	cell chemotaxis	HBEGF	IMP		Human	PMID:24008408
Biological Process	GO:0016477	cell migration	Hbegf	IMP		Mouse	MGI:MGI:3580979|PMID:15923649
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	HBEGF	IMP		Human	PMID:17655843
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	HBEGF	IDA		Human	PMID:8702723
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Hbegf	IDA		Mouse	PMID:12621152
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Hbegf	IMP		Rat	PMID:15486316|RGD:1581908
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	Hbegf	IMP	MGI:MGI:2665039	Mouse	PMID:21946538
Biological Process	GO:0038135	ERBB2-ERBB4 signaling pathway	Hbegf	IMP	MGI:MGI:2655703	Mouse	PMID:12621152
Biological Process	GO:0060047	heart contraction	hbegfb	IMP	ZFIN:ZDB-MRPHLNO-100503-19	Zfish	PMID:19064678
Biological Process	GO:0051545	negative regulation of elastin biosynthetic process	Hbegf	IDA		Rat	PMID:12882762|RGD:8554842
Biological Process	GO:0030307	positive regulation of cell growth	Hbegf	IDA		Rat	PMID:11956950|RGD:728846
Biological Process	GO:0030335	positive regulation of cell migration	HBEGF	IMP		Human	PMID:17655843
Biological Process	GO:0008284	positive regulation of cell population proliferation	Hbegf	IDA		Mouse	PMID:8702723
Biological Process	GO:0051549	positive regulation of keratinocyte migration	Hbegf	IMP		Mouse	MGI:MGI:3580979|PMID:15923649
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Hbegf	IDA		Mouse	PMID:8702723
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	HBEGF	IMP		Human	PMID:17655843
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Hbegf	IDA		Mouse	MGI:MGI:3690187|PMID:1840698
Biological Process	GO:0090303	positive regulation of wound healing	HBEGF	IMP		Human	PMID:17655843
Biological Process	GO:0008016	regulation of heart contraction	Hbegf	IMP	MGI:MGI:2655703	Mouse	PMID:12621152
Biological Process	GO:0009611	response to wounding	hbegfa	IMP	ZFIN:ZDB-MRPHLNO-121017-3	Zfish	PMID:22340497
Biological Process	GO:0060041	retina development in camera-type eye	hbegfa	IMP	ZFIN:ZDB-MRPHLNO-121017-3	Zfish	PMID:22340497
Biological Process	GO:0070654	sensory epithelium regeneration	hbegfa	IMP	ZFIN:ZDB-MRPHLNO-121017-3	Zfish	PMID:22340497
Biological Process	GO:0070654	sensory epithelium regeneration	hbegfa	IGI	ZFIN:ZDB-GENE-040426-1810	Zfish	PMID:23000964
Biological Process	GO:0035313	wound healing, spreading of epidermal cells	Hbegf	IMP		Mouse	MGI:MGI:3580979|PMID:15923649

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern