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Hbegf
Gene Detail
Symbol

Name
ID
Hbegf
heparin-binding EGF-like growth factor
MGI:96070
Synonyms
Dtr, HB-EGF, Hegfl
Feature Type
protein coding gene
Genetic Map
Chromosome 18
19.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:36504929-36515805 bp, - strand
From Ensembl annotation of GRCm38

  10877 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1466  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: HBEGF
Protein SuperFamily: heparin-binding EGF-like growth factor
Gene Tree: Hbegf

Human
homologs
HBEGF, heparin-binding EGF-like growth factor
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1839
neXtProt AC: NX_Q99075

Human Synonyms: DTR, DTS, DTSF, HEGFL

Human Chr (Location): 5q23; chr5:140332843-140346603 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(16) Targeted(10) Transgenic(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit grossly enlarged heart valves and ventricular chambers, and hypoplastic, immature lungs. Most mutants die by 3 weeks of age. Conditional deletion specifically in thge ventral forebrain results in behavior abnormalities and defects in pyramidal neurons.
 
Phenotype Images(2)
Interactions
Hbegf interacts with 208 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process angiogenesis, blastocyst growth, ...
Component cell surface, extracellular region, ...
Function epidermal growth factor receptor binding, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (62)    Tissues (32)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 7
In situ reporter (knock in) 16
Northern blot 9
Western blot 1
RT-PCR 23
cDNA source data(30)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase hbegf    NEW 
Molecular
reagents
All nucleic(37) Genomic(2) cDNA(31) Primer pair(3) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000024486 (Evidence)
Entrez Gene 15200 (Evidence)
UniGene 289681
DFCI TC1579973
DoTS DT.40168892, DT.55162150, DT.94359502
NIA Mouse Gene Index U038335
Consensus CDS Project CCDS29153.1
International Mouse Phenotyping Consortium Status Hbegf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024486 Ensembl Gene Model | MGI Sequence Detail 10877 C57BL/6J ±  kb
transcript ENSMUST00000025363 Ensembl | MGI Sequence Detail 2373 Not Applicable 
polypeptide ENSMUSP00000025363 Ensembl | MGI Sequence Detail 208 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR015497 Epidermal growth factor receptor ligand
Protein Ontology PR:000008459 proheparin-binding EGF-like growth factor
References
(Earliest) J:114809 Higashiyama S, et al., A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science. 1991 Feb 22;251(4996):936-9
(Latest) J:211269 Hosur V, et al., Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin. Proc Natl Acad Sci U S A. 2014 May 27;111(21):E2200-9
All references(99)
Other
accession IDs
MGD-MRK-10692, MGI:2147342

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory