About   Help   FAQ
Hbegf Gene Detail
Summary
  • Symbol
    Hbegf
  • Name
    heparin-binding EGF-like growth factor
  • Synonyms
    Dtr, HB-EGF, Hegfl
  • Feature Type
    protein coding gene
  • IDs
    MGI:96070
    NCBI Gene: 15200
Location & Maps
more
  • Sequence Map
    Chr18:36504929-36515805 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10877 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 19.46 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HBEGF, heparin binding EGF like growth factor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HBEGF, heparin binding EGF like growth factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DTR, DTS, DTSF, HEGFL
  • Links
    NCBI Gene ID: 1839
    neXtProt AC: NX_Q99075

  • Chr Location
    5q23; chr5:140332843-140346603 (-)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 7 alleles in 7 genetic backgrounds
    36 phenotypes from multigenic genotypes
    2 images
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit grossly enlarged heart valves and ventricular chambers, and hypoplastic, immature lungs. Most mutants die by 3 weeks of age. Conditional deletion specifically in thge ventral forebrain results in behavior abnormalities and defects in pyramidal neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024486 Ensembl Gene Model | MGI Sequence Detail 10877 C57BL/6J ±  kb
transcript ENSMUST00000025363 Ensembl | MGI Sequence Detail 2373 Not Applicable  
polypeptide ENSMUSP00000025363 Ensembl | MGI Sequence Detail 208 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    26 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008459 proheparin-binding EGF-like growth factor
  • InterPro Domains
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR015497 Epidermal growth factor receptor ligand
Molecular
Reagents
less
  • All nucleic 38
    Genomic 2
    cDNA 31
    Primer pair 4
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-10692, MGI:2147342
References
more
  • Summaries
    All 99
    Developmental Gene Expression 27
    Diseases 1
    Gene Ontology 9
    Phenotypes 52
  • Earliest
    J:114809 Higashiyama S, et al., A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science. 1991 Feb 22;251(4996):936-9
  • Latest
    J:230794 Stumpo DJ, et al., Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism. Development. 2016 Apr 15;143(8):1424-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory