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Hbegf
Gene Detail
 Symbol
Name
ID
Hbegf
heparin-binding EGF-like growth factor
MGI:96070
Synonyms Dtr, HB-EGF, Hegfl
Feature Type protein coding gene
Genetic Map
Chromosome 18
19.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:36504929-36515805 bp, - strand
From Ensembl annotation of GRCm38

  10877 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1466  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: heparin-binding EGF-like growth factor
Gene Tree: Hbegf

Human
homologs
Human Homolog HBEGF, heparin-binding EGF-like growth factor
NCBI Gene ID 1839
neXtProt AC  NX_Q99075
Human Synonyms  DTR, DTS, DTSF, HEGFL
Human Chr (Location)  5q23; chr5:140332843-140346603 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(16) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit grossly enlarged heart valves and ventricular chambers, and hypoplastic, immature lungs. Most mutants die by 3 weeks of age. Conditional deletion specifically in thge ventral forebrain results in behavior abnormalities and defects in pyramidal neurons.
 
Phenotype Images(2)
Interactions
Hbegf interacts with 208 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process angiogenesis, blastocyst growth, ...
Component cell surface, extracellular region, ...
Function epidermal growth factor receptor binding, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (62)    Tissues (32)    Images (26)
Theiler Stages: 17, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 7
In situ reporter (knock in) 16
Northern blot 9
Western blot 1
RT-PCR 23
cDNA source data(30)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) Genomic(2) cDNA(31) Primer pair(3) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000024486 (Evidence)
Entrez Gene15200 (Evidence)
UniGene289681
DFCITC1579973
DoTSDT.40168892, DT.55162150, DT.94359502
NIA Mouse Gene IndexU038335
Consensus CDS ProjectCCDS29153.1
International Mouse Knockout Project StatusHbegf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024486 Ensembl Gene Model | MGI Sequence Detail 10877 C57BL/6J ±  kb
transcript ENSMUST00000025363 Ensembl | MGI Sequence Detail 2373 Not Applicable 
polypeptide ENSMUSP00000025363 Ensembl | MGI Sequence Detail 208 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR015497 Epidermal growth factor receptor ligand
Protein Ontology PR:000008459 proheparin-binding EGF-like growth factor
References (Earliest) J:114809 Higashiyama S, et al., A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science. 1991 Feb 22;251(4996):936-9
(Latest) J:204425 Takemura T, et al., Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice. Biochem Biophys Res Commun. 2013 Jul 26;437(2):185-91
All references(97)
Other
accession IDs
MGD-MRK-10692, MGI:2147342

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory