Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HM13
  • Mouse genes H13
  • Rat genes Hm13
  • Zfish genes hm13
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set H13

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	HM13	IMP		Human	PMID:16873890
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	HM13	IDA		Human	PMID:25239945
Molecular Function	GO:0008233	peptidase activity	HM13	IDA		Human	PMID:14741365
Molecular Function	GO:0005515	protein binding	HM13	IPI	UniProtKB:Q8WU17	Human	PMID:19720873
Molecular Function	GO:0005515	protein binding	HM13	IPI	UniProtKB:P07237	Human	PMID:19942855
Molecular Function	GO:0005515	protein binding	HM13	IPI	UniProtKB:P17861-1	Human	PMID:25239945
Molecular Function	GO:0005515	protein binding	HM13	IPI	UniProtKB:Q8WU17	Human	PMID:25239945
Molecular Function	GO:0005515	protein binding	HM13	IPI	UniProtKB:Q9BUN8	Human	PMID:25239945
Molecular Function	GO:0005515	protein binding	HM13	IPI	UniProtKB:Q9BRK4	Human	PMID:25416956
Molecular Function	GO:0042803	protein homodimerization activity	HM13	IDA		Human	PMID:15385547
Molecular Function	GO:0042803	protein homodimerization activity	HM13	IDA		Human	PMID:15998642
Molecular Function	GO:0042803	protein homodimerization activity	HM13	IDA		Human	PMID:16873890
Molecular Function	GO:0031625	ubiquitin protein ligase binding	HM13	IPI	UniProtKB:Q8WU17	Human	PMID:25239945
Cellular Component	GO:0009986	cell surface	H13	IDA		Mouse	MGI:MGI:3689482|PMID:16730383
Cellular Component	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	HM13	IDA		Human	PMID:15385547
Cellular Component	GO:0036513	Derlin-1 retrotranslocation complex	HM13	IDA		Human	PMID:25239945
Cellular Component	GO:0005783	endoplasmic reticulum	HM13	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	H13	IDA		Mouse	MGI:MGI:3689482|PMID:16730383
Cellular Component	GO:0005783	endoplasmic reticulum	H13	IDA		Mouse	PMID:12972007
Cellular Component	GO:0005789	endoplasmic reticulum membrane	H13	IDA		Mouse	PMID:12972007
Cellular Component	GO:0098553	lumenal side of endoplasmic reticulum membrane	HM13	IDA		Human	PMID:15385547
Cellular Component	GO:0016020	membrane	HM13	HDA		Human	PMID:19946888
Cellular Component	GO:0005791	rough endoplasmic reticulum	HM13	IDA		Human	PMID:15998642
Cellular Component	GO:0005791	rough endoplasmic reticulum	HM13	IDA		Human	PMID:16829952
Biological Process	GO:0001701	in utero embryonic development	H13	IMP	MGI:MGI:5637209	Mouse	PMID:27996060
Biological Process	GO:0033619	membrane protein proteolysis	HM13	IDA		Human	PMID:14741365
Biological Process	GO:1904211	membrane protein proteolysis involved in retrograde protein transport, ER to cytosol	HM13	IMP		Human	PMID:25239945
Biological Process	GO:0043523	regulation of neuron apoptotic process	hm13	IMP		Zfish	PMID:15998642

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern