H13
Gene Detail

Symbol Name ID

H13 histocompatibility 13 MGI:95886

Synonyms

1200006O09Rik, 4930443L17Rik, 5031424B04Rik, H-13, Spp

Feature Type

protein coding gene

Genetic Map

Chromosome 2

75.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr2:152669461-152708670 bp, + strand From VEGA annotation of GRCm38   39210 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7749  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: H13

Human homologs

Human Homolog		HM13, histocompatibility (minor) 13
NCBI Gene ID		81502
neXtProt AC		NX_Q8TCT9
Human Synonyms		dJ324O17.1, H13, IMP1, IMPAS, IMPAS-1, MSTP086, PSENL3, PSL3, SPP, SPPL1
Human Chr (Location)		20q11.21; chr20:30102241-30157370 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(27) : Targeted(1) Gene trapped(26)
 

This is one of several loci identified by development of congenic strains differing in resistance to transplantable tumors. C57BL/10 carries the a allele and B10.129(14M) carries the b allele.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	membrane protein proteolysis, proteolysis
Component	cell surface, endoplasmic reticulum, ...
Function	aspartic endopeptidase activity, intramembrane cleaving, aspartic-type endopeptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (54)    Tissues (18)   
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
RNA in situ	28
RT-PCR	26

cDNA source data(175)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(180) cDNA(176) Primer pair(4)
Microarray probesets(10)

Other database links

VEGA Gene Model	OTTMUSG00000015824 (Evidence)
Ensembl Gene Model	ENSMUSG00000019188 (Evidence)
Entrez Gene	14950 (Evidence)
UniGene	277327
DFCI	TC1573047, TC1584248, TC1587865, TC1588110, TC1589010, TC1697481
DoTS	DT.101710625, DT.495217, DT.55263571, DT.55275604, DT.94178805, DT.94359034, DT.97401570, DT.97401571
NIA Mouse Gene Index	U002650
EC	3.4.23.-
PDB	1INQ, 1JUF
Consensus CDS Project	CCDS16896.1, CCDS50752.1, CCDS50753.1
International Mouse Knockout Project Status	H13

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015824	VEGA Gene Model | MGI Sequence Detail	39210	C57BL/6J
transcript	OTTMUST00000037623	VEGA | MGI Sequence Detail	1743	Not Applicable
polypeptide	OTTMUSP00000016863	VEGA | MGI Sequence Detail	394	Not Applicable

All sequences(90) RefSeq(8) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(224 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007369	Peptidase A22B, signal peptide peptidase
InterPro	IPR006639	Peptidase A22, presenilin signal peptide
Protein Ontology	PR:000008621	minor histocompatibility antigen H13

References

(Earliest) J:5026 Graff RJ, et al., Histocompatibility genes of mice. VI. Allografts in mice congenic at various non-H-2 histocompatibility loci. Transplantation. 1966 Jul;4(4):425-37
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(53)

Other accession IDs

MGD-MRK-10359, MGD-MRK-10481, MGI:1914866, MGI:1915400, MGI:2139237, MGI:2447815