H13 MGI Mouse Gene Detail - MGI:95886

Symbol

H13
Name

histocompatibility 13
Synonyms

1200006O09Rik, 4930443L17Rik, 5031424B04Rik, H-13, Hm13, Spp

Feature Type

protein coding gene
IDs

MGI:95886
NCBI Gene: 14950
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:152511381-152550590 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 75.41 cM
Mapping Data

10 experiments

SNPs within 2kb

335 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95886	protein coding gene	Chr2:152511292-152550590 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026674	protein coding gene	Chr2:157240210-157283604 (+)
A/J	MGP_AJ_G0026640	protein coding gene	Chr2:150951282-151002400 (+)
AKR/J	MGP_AKRJ_G0026610	protein coding gene	Chr2:155365396-155404586 (+)
BALB/cJ	MGP_BALBcJ_G0026649	protein coding gene	Chr2:151272517-151312380 (+)
C3H/HeJ	MGP_C3HHeJ_G0026392	protein coding gene	Chr2:155750886-155790006 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027098	protein coding gene	Chr2:161806349-161845544 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024469	protein coding gene	Chr2:144554131-144593133 (+)
CAST/EiJ	MGP_CASTEiJ_G0025853	protein coding gene	Chr2:156003020-156042278 (+)
CBA/J	MGP_CBAJ_G0026370	protein coding gene	Chr2:167761820-167801732 (+)
DBA/2J	MGP_DBA2J_G0026506	protein coding gene	Chr2:150176721-150216144 (+)
FVB/NJ	MGP_FVBNJ_G0026472	protein coding gene	Chr2:148629200-148669482 (+)
LP/J	MGP_LPJ_G0026610	protein coding gene	Chr2:157396423-157438239 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026493	protein coding gene	Chr2:171849501-171889623 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027154	protein coding gene	Chr2:155245605-155301075 (+)
PWK/PhJ	MGP_PWKPhJ_G0025587	protein coding gene	Chr2:149688244-149736267 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025390	protein coding gene	Chr2:154104443-154145872 (+)
WSB/EiJ	MGP_WSBEiJ_G0025923	protein coding gene	Chr2:156171009-156210129 (+)

Human Ortholog

HM13, histocompatibility minor 13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HM13, histocompatibility minor 13
Synonyms

H13, IMP1, IMPAS, IMPAS-1, MSTP086, PSENL3, PSL3, SPP, SPPL1
Links

HGNC:16435

NCBI Gene ID: 81502

neXtProt AC: NX_Q8TCT9

UniProt: Q8TCT9
Chr Location

20q11.21; chr20:31514428-31577923 (+) GRCh38

MGI Vertebrate Homology

H13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HM13
Gene Tree

H13

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Phenotype Summary

89 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

25
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving H13
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

This is one of several loci identified by development of congenic strains differing in resistance to transplantable tumors. C57BL/10 carries the a allele and B10.129(14M) carries the b allele.

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All GO Annotations

31
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

970
Tissues

105
cDNA Data

181
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

90
RefSeq

15
UniProt

5
CCDS

CCDS16896.1, CCDS50752.1, CCDS50753.1

Ensembl

ENSMUSG00000019188 (Evidence)
NCBI Gene

14950

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019188	Ensembl Gene Model \| MGI Sequence Detail	39210	C57BL/6J	± kb
transcript	ENSMUST00000089059	Ensembl \| MGI Sequence Detail	1743	Not Applicable
polypeptide	ENSMUSP00000086460	Ensembl \| MGI Sequence Detail	394	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008621 minor histocompatibility antigen H13

(term hierarchy)
PDB

1INQ, 1JUF
EC

3.4.23.-
InterPro Domains

IPR007369 Peptidase A22B, signal peptide peptidase

IPR042524 Presenilin, C-terminal

IPR006639 Presenilin/signal peptide peptidase

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All nucleic 191

cDNA 182

Primer pair 8

Other 1

Microarray probesets 10

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MGD-MRK-10359, MGD-MRK-10481, MGI:1914866, MGI:1915400, MGI:2139237, MGI:2447815

Summaries

All 68

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 18
Earliest

J:5026 Graff RJ, et al., Histocompatibility genes of mice. VI. Allografts in mice congenic at various non-H-2 histocompatibility loci. Transplantation. 1966 Jul;4(4):425-37
Latest

J:322523 Wang S, et al., Absence of signal peptide peptidase in peripheral sensory neurons affects latency-reactivation in HSV-1 ocularly infected mice. PLoS Pathog. 2022 Jan;18(1):e1010281

TSS for H13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20813	Chr2:152511382-152511459 (+)	40 bp
Tssr20814	Chr2:152519491-152519514 (+)	8,122 bp
Tssr20823	Chr2:152536906-152536933 (+)	25,539 bp
Tssr20824	Chr2:152537378-152537396 (+)	26,006 bp
Tssr20825	Chr2:152537427-152537438 (+)	26,052 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23