Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GRM8
  • Mouse genes Grm8
  • Rat genes Grm8
  • Zfish genes grm8a,grm8b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grm8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	GRM8	IMP		Human	PMID:9473604
Molecular Function	GO:0008066	glutamate receptor activity	GRM8	IMP		Human	PMID:9473604
Molecular Function	GO:0001642	group III metabotropic glutamate receptor activity	Grm8	IDA		Mouse	PMID:7722646
Molecular Function	GO:0001642	group III metabotropic glutamate receptor activity	Grm8	IDA		Rat	PMID:9875342|RGD:632860
Cellular Component	GO:0098982	GABA-ergic synapse	Grm8	EXP		Rat	PMID:15275822|RGD:6484726
Cellular Component	GO:0098982	GABA-ergic synapse	Grm8	IDA		Rat	PMID:15275822|RGD:6484726
Cellular Component	GO:0098982	GABA-ergic synapse	Grm8	IDA		Rat	PMID:9295396|RGD:13702410
Cellular Component	GO:0098978	glutamatergic synapse	Grm8	EXP		Rat	PMID:15275822|RGD:6484726
Cellular Component	GO:0098978	glutamatergic synapse	Grm8	IDA		Rat	PMID:15275822|RGD:6484726
Cellular Component	GO:0098978	glutamatergic synapse	Grm8	IDA		Rat	PMID:9295396|RGD:13702410
Cellular Component	GO:0043005	neuron projection	Grm8	IDA		Rat	PMID:12443992|RGD:1299249
Cellular Component	GO:0043025	neuronal cell body	Grm8	IDA		Rat	PMID:12443992|RGD:1299249
Cellular Component	GO:0005886	plasma membrane	Grm8	IDA		Rat	PMID:16045496|RGD:8554809
Cellular Component	GO:0048787	presynaptic active zone membrane	Grm8	IDA		Rat	PMID:9295396|RGD:13702410
Cellular Component	GO:0042734	presynaptic membrane	Grm8	IDA		Rat	PMID:15275822|RGD:6484726
Biological Process	GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	GRM8	IMP		Human	PMID:9473604
Biological Process	GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	Grm8	IDA		Mouse	MGI:MGI:72270|PMID:7722646
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	GRM8	IDA		Human	PMID:11166323
Biological Process	GO:0007268	chemical synaptic transmission	Grm8	IDA		Rat	PMID:15275822|RGD:6484726
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	Grm8	IDA		Rat	PMID:18533199|RGD:6771181
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Grm8	EXP		Rat	PMID:15275822|RGD:6484726
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Grm8	IDA		Rat	PMID:15275822|RGD:6484726
Biological Process	GO:0046928	regulation of neurotransmitter secretion	Grm8	IDA		Rat	PMID:16084932|RGD:6484727
Biological Process	GO:0035249	synaptic transmission, glutamatergic	Grm8	IDA		Rat	PMID:15275822|RGD:6484726

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern