Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GRM4
  • Mouse genes Grm4
  • Rat genes Grm4
  • Zfish genes grm4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grm4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048306	calcium-dependent protein binding	Grm4	IPI	RGD:2257	Rat	PMID:21855531|RGD:7207139
Molecular Function	GO:0048306	calcium-dependent protein binding	Grm4	IPI	RGD:620385	Rat	PMID:21855531|RGD:7207139
Molecular Function	GO:0005516	calmodulin binding	Grm4	IPI	RGD:2257	Rat	PMID:21855531|RGD:7207139
Molecular Function	GO:0004930	G protein-coupled receptor activity	GRM4	IMP		Human	PMID:8738157
Molecular Function	GO:0004930	G protein-coupled receptor activity	GRM4	IMP		Human	PMID:9473604
Molecular Function	GO:0008066	glutamate receptor activity	GRM4	IMP		Human	PMID:8738157
Molecular Function	GO:0008066	glutamate receptor activity	GRM4	IMP		Human	PMID:9473604
Molecular Function	GO:0005515	protein binding	Grm4	IPI	UniProtKB:O08599-1	Rat	PMID:19822743|RGD:13432340
Cellular Component	GO:0150048	cerebellar granule cell to Purkinje cell synapse	Grm4	IDA		Mouse	PMID:32494600
Cellular Component	GO:0031410	cytoplasmic vesicle	GRM4	IDA		Human	PMID:15102938
Cellular Component	GO:0043198	dendritic shaft	Grm4	IDA		Rat	PMID:11906782|RGD:8554275
Cellular Component	GO:0098978	glutamatergic synapse	Grm4	IDA		Mouse	PMID:11906782
Cellular Component	GO:0098978	glutamatergic synapse	Grm4	IDA		Mouse	PMID:8815915
Cellular Component	GO:0098978	glutamatergic synapse	Grm4	EXP		Mouse	PMID:8815915
Cellular Component	GO:0098978	glutamatergic synapse	Grm4	IMP		Mouse	PMID:8815915
Cellular Component	GO:0098978	glutamatergic synapse	Grm4	IDA		Mouse	PMID:32494600
Cellular Component	GO:0043005	neuron projection	Grm4	IDA		Mouse	MGI:MGI:5320264|PMID:21795692
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	Grm4	IDA		Mouse	PMID:8815915
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	Grm4	EXP		Mouse	PMID:8815915
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	Grm4	IMP		Mouse	PMID:8815915
Cellular Component	GO:0005886	plasma membrane	GRM4	IDA		Human	PMID:15102938
Cellular Component	GO:0048787	presynaptic active zone membrane	Grm4	IDA		Mouse	PMID:11906782
Cellular Component	GO:0048787	presynaptic active zone membrane	Grm4	IDA		Mouse	PMID:32494600
Cellular Component	GO:0048787	presynaptic active zone membrane	Grm4	IDA		Rat	PMID:11906782|RGD:8554275
Cellular Component	GO:0043195	terminal bouton	Grm4	IDA		Rat	PMID:11906782|RGD:8554275
Biological Process	GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	GRM4	IMP		Human	PMID:15102938
Biological Process	GO:0007268	chemical synaptic transmission	Grm4	IMP	MGI:MGI:1857980	Mouse	PMID:8815915
Biological Process	GO:0007612	learning	Grm4	IMP	MGI:MGI:1857980	Mouse	PMID:8815915
Biological Process	GO:0043410	positive regulation of MAPK cascade	GRM4	IDA		Human	PMID:15102938
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Grm4	IDA		Mouse	PMID:8815915
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Grm4	IMP		Mouse	PMID:8815915
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Grm4	EXP		Mouse	PMID:8815915

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern