Grm4
Gene Detail

Symbol Name ID

Grm4 glutamate receptor, metabotropic 4 MGI:1351341

Synonyms

Gprc1d, mGluR4

Feature Type

protein coding gene

Genetic Map

Chromosome 17

14.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr17:27422387-27513341 bp, - strand From VEGA annotation of GRCm38   90955 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20230  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Grm4

Human homologs

Human Homolog		GRM4, glutamate receptor, metabotropic 4
NCBI Gene ID		2914
neXtProt AC		NX_Q14833
Human Synonyms		GPRC1D, mGlu4, MGLUR4
Human Chr (Location)		6p21.3; chr6:33989623-34123399 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(2) Gene trapped(4)
 

Homozygous mutation of theis gene results in impaired motor learning, and reduced paired-pulse facilitation and post-tetanic potential.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	activation of MAPK activity, adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway, ...
Component	cytoplasmic vesicle, dendritic shaft, ...
Function	calcium-dependent protein binding, calmodulin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (169)    Tissues (43)    Images (36)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	169

cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(11)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000028925 (Evidence)
Ensembl Gene Model	ENSMUSG00000063239 (Evidence)
Entrez Gene	268934 (Evidence)
UniGene	358940
DFCI	TC1592360, TC1601759
DoTS	DT.103584140, DT.55202624
Consensus CDS Project	CCDS28563.1
International Mouse Knockout Project Status	Grm4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028925	VEGA Gene Model | MGI Sequence Detail	90955	C57BL/6J
transcript	OTTMUST00000071686	VEGA | MGI Sequence Detail	4537	Not Applicable
polypeptide	OTTMUSP00000036784	VEGA | MGI Sequence Detail	912	Not Applicable

All sequences(30) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(294 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR000337	GPCR, family 3
InterPro	IPR017979	GPCR, family 3, conserved site
InterPro	IPR017978	GPCR, family 3, C-terminal
InterPro	IPR000162	GPCR, family 3, metabotropic glutamate receptor
InterPro	IPR001786	GPCR, family 3, metabotropic glutamate receptor 4
InterPro	IPR011500	GPCR, family 3, nine cysteines domain
Protein Ontology	PR:000008266	metabotropic glutamate receptor 4

References

(Earliest) J:35793 Pekhletski R, et al., Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGluR4 subtype of metabotropic glutamate receptor. J Neurosci. 1996 Oct 15;16(20):6364-73
(Latest) J:192658 Davis MJ, et al., Role of mGluR4 in acquisition of fear learning and memory. Neuropharmacology. 2013 Mar;66:365-72
All references(46)

Other accession IDs

MGD-MRK-10267, MGI:95828