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Grm4
Gene Detail
 Symbol
Name
ID
Grm4
glutamate receptor, metabotropic 4
MGI:1351341
Synonyms Gprc1d, mGluR4
Feature Type protein coding gene
Genetic Map
Chromosome 17
14.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:27422387-27513341 bp, - strand
From VEGA annotation of GRCm38

  90955 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20230  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Grm4

Human
homologs
Human Homolog GRM4, glutamate receptor, metabotropic 4
NCBI Gene ID 2914
neXtProt AC  NX_Q14833
Human Synonyms  GPRC1D, mGlu4, MGLUR4
Human Chr (Location)  6p21.3; chr6:34018643-34155622 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Radiation induced(1) Targeted(2)
Genomic Mutations involving Grm4 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of theis gene results in impaired motor learning, and reduced paired-pulse facilitation and post-tetanic potential.
 
Interactions
Grm4 interacts with 164 markers (Mir15a, Mir19a, Mir25, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process activation of MAPK activity, adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway, ...
Component cytoplasmic vesicle, dendritic shaft, ...
Function calcium-dependent protein binding, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (169)    Tissues (43)    Images (36)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 169
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000028925 (Evidence)
Ensembl Gene ModelENSMUSG00000063239 (Evidence)
Entrez Gene268934 (Evidence)
UniGene358940
DFCITC1592360, TC1601759
DoTSDT.103584140, DT.55202624
Consensus CDS ProjectCCDS28563.1, CCDS70775.1
International Mouse Knockout Project StatusGrm4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028925 VEGA Gene Model | MGI Sequence Detail 90955 C57BL/6J ±  kb
transcript OTTMUST00000071686 VEGA | MGI Sequence Detail 4537 Not Applicable 
polypeptide OTTMUSP00000036784 VEGA | MGI Sequence Detail 912 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(26) UniProt(2)
Polymorphisms SNPs within 2kb(666 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR000162 GPCR, family 3, metabotropic glutamate receptor
InterPro IPR001786 GPCR, family 3, metabotropic glutamate receptor 4
InterPro IPR011500 GPCR, family 3, nine cysteines domain
Protein Ontology PR:000008266 metabotropic glutamate receptor 4
References (Earliest) J:35793 Pekhletski R, et al., Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGluR4 subtype of metabotropic glutamate receptor. J Neurosci. 1996 Oct 15;16(20):6364-73
(Latest) J:204154 Vilar B, et al., Alleviating pain hypersensitivity through activation of type 4 metabotropic glutamate receptor. J Neurosci. 2013 Nov 27;33(48):18951-65
All references(50)
Other
accession IDs
MGD-MRK-10267, MGI:95828

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory