Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GRB10
  • Mouse genes Grb10
  • Rat genes Grb10
  • Zfish genes grb10a,grb10b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grb10

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005158	insulin receptor binding	Grb10	IPI	UniProtKB:P15208	Mouse	MGI:MGI:3847873|PMID:15664450
Molecular Function	GO:0005158	insulin receptor binding	Grb10	IDA		Rat	PMID:11223174|RGD:8553640
Molecular Function	GO:0005515	protein binding	GRB10	IPI	UniProtKB:P46935	Human	PMID:15060076
Molecular Function	GO:0005515	protein binding	GRB10	IPI	UniProtKB:P62258	Human	PMID:15722337
Molecular Function	GO:0005515	protein binding	GRB10	IPI	UniProtKB:Q6Y7W6	Human	PMID:20670374
Molecular Function	GO:0005515	protein binding	GRB10	IPI	UniProtKB:O75420,UniProtKB:P00533,UniProtKB:P31749,UniProtKB:Q6Y7W6,UniProtKB:Q92600	Human	PMID:20878056
Molecular Function	GO:0005515	protein binding	GRB10	IPI	UniProtKB:O75420,UniProtKB:Q92600	Human	PMID:20878056
Molecular Function	GO:0005515	protein binding	GRB10	IPI	UniProtKB:Q6Y7W6,UniProtKB:Q92600	Human	PMID:20878056
Molecular Function	GO:0005515	protein binding	GRB10	IPI	UniProtKB:Q92600	Human	PMID:20878056
Molecular Function	GO:0005515	protein binding	GRB10	IPI	UniProtKB:P27986	Human	PMID:23246379
Molecular Function	GO:0005515	protein binding	GRB10	IPI	UniProtKB:P36888	Human	PMID:23246379
Molecular Function	GO:0005515	protein binding	GRB10	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	GRB10	IPI	UniProtKB:Q9UKA8	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	GRB10	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	GRB10	IPI	UniProtKB:P54762	Human	PMID:8798570
Molecular Function	GO:0005515	protein binding	GRB10	IPI	UniProtKB:P00533	Human	PMID:9506989
Molecular Function	GO:0005515	protein binding	GRB10	IPI	UniProtKB:P06213	Human	PMID:9506989
Molecular Function	GO:0005515	protein binding	Grb10	IPI	UniProtKB:P31750|UniProtKB:P62259	Mouse	MGI:MGI:3579938|PMID:15722337
Molecular Function	GO:0005515	protein binding	Grb10	IPI	UniProtKB:P15208	Mouse	MGI:MGI:5508317|PMID:8621530
Molecular Function	GO:0005515	protein binding	Grb10	IPI	UniProtKB:P46935	Mouse	MGI:MGI:1342855|PMID:10446181
Molecular Function	GO:0005515	protein binding	Grb10	IPI	UniProtKB:O88572	Mouse	MGI:MGI:4821069|PMID:17376403
Molecular Function	GO:0005515	protein binding	Grb10	IPI	PR:Q99MR1	Mouse	PMID:12771153
Molecular Function	GO:0005515	protein binding	Grb10	IPI	PR:Q6Y7W8	Mouse	PMID:12771153
Molecular Function	GO:0005515	protein binding	Grb10	IPI	PR:Q60751	Mouse	PMID:12771153
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	Grb10	IDA		Mouse	PMID:9062339
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	Grb10	IPI	UniProtKB:P15208	Mouse	MGI:MGI:3847873|PMID:15664450
Cellular Component	GO:0032991	protein-containing complex	GRB10	IDA		Human	PMID:20878056
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Grb10	IMP		Mouse	PMID:26941017
Biological Process	GO:0010467	gene expression	Grb10	IMP		Mouse	PMID:26941017
Biological Process	GO:0008286	insulin receptor signaling pathway	Grb10	IDA		Rat	PMID:11223174|RGD:8553640
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Grb10	IPI	PR:Q60751	Mouse	PMID:12771153
Biological Process	GO:0046325	negative regulation of glucose import	Grb10	IMP		Mouse	MGI:MGI:3847873|PMID:15664450
Biological Process	GO:0045719	negative regulation of glycogen biosynthetic process	Grb10	IDA		Rat	PMID:11223174|RGD:8553640
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Grb10	IMP		Mouse	MGI:MGI:3847873|PMID:15664450
Biological Process	GO:0042326	negative regulation of phosphorylation	Grb10	IDA		Mouse	MGI:MGI:3847873|PMID:15664450
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	GRB10	IDA		Human	PMID:17376403
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Grb10	IDA		Mouse	MGI:MGI:4821069|PMID:17376403
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Grb10	IMP		Mouse	MGI:MGI:5585374|PMID:24746805
Biological Process	GO:0042327	positive regulation of phosphorylation	Grb10	IDA		Rat	PMID:11223174|RGD:8553640
Biological Process	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	GRB10	IDA		Human	PMID:15060076
Biological Process	GO:0032868	response to insulin	Grb10	IDA		Rat	PMID:11223174|RGD:8553640
Biological Process	GO:1904738	vascular associated smooth muscle cell migration	Grb10	IMP		Mouse	PMID:26941017

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern