Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GPR39
  • Mouse genes Gpr39
  • Rat genes Gpr39
  • Zfish genes gpr39
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gpr39

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	Gpr39	IMP		Mouse	PMID:26375174
Molecular Function	GO:0005515	protein binding	GPR39	IPI	UniProtKB:P08908	Human	PMID:26365466
Biological Process	GO:0008343	adult feeding behavior	Gpr39	IMP	MGI:MGI:3723512	Mouse	PMID:17030183
Biological Process	GO:0071294	cellular response to zinc ion	Gpr39	IMP	MGI:MGI:3701833	Mouse	PMID:23133519
Biological Process	GO:0071294	cellular response to zinc ion	Gpr39	IMP		Mouse	PMID:26375174
Biological Process	GO:0042632	cholesterol homeostasis	Gpr39	IMP	MGI:MGI:3723512	Mouse	PMID:17030183
Biological Process	GO:0002024	diet induced thermogenesis	Gpr39	IMP	MGI:MGI:3701833	Mouse	PMID:21784784
Biological Process	GO:0051649	establishment of localization in cell	Gpr39	IMP	MGI:MGI:3701833	Mouse	PMID:23133519
Biological Process	GO:0051649	establishment of localization in cell	Gpr39	IMP	MGI:MGI:3723512	Mouse	PMID:19213841
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	gpr39	IDA		Zfish	PMID:32916170
Biological Process	GO:0001696	gastric acid secretion	Gpr39	IMP	MGI:MGI:3723512	Mouse	PMID:17030183
Biological Process	GO:0035483	gastric emptying	Gpr39	IMP	MGI:MGI:3723512	Mouse	PMID:17030183
Biological Process	GO:0042593	glucose homeostasis	Gpr39	IMP	MGI:MGI:3701833	Mouse	PMID:21784784
Biological Process	GO:0042593	glucose homeostasis	Gpr39	IMP	MGI:MGI:3701833	Mouse	PMID:19213833
Biological Process	GO:0030073	insulin secretion	Gpr39	IMP	MGI:MGI:3723512	Mouse	PMID:19213841
Biological Process	GO:0035773	insulin secretion involved in cellular response to glucose stimulus	Gpr39	IMP	MGI:MGI:3701833	Mouse	PMID:19213833
Biological Process	GO:0060455	negative regulation of gastric acid secretion	Gpr39	IMP	MGI:MGI:3723512	Mouse	PMID:17030183
Biological Process	GO:0070050	neuron cellular homeostasis	Gpr39	IMP		Mouse	PMID:26375174
Biological Process	GO:0032024	positive regulation of insulin secretion	Gpr39	IMP	MGI:MGI:3723512	Mouse	PMID:19213841
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Gpr39	IMP	MGI:MGI:3701833	Mouse	PMID:19213833
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Gpr39	IMP		Mouse	PMID:26375174
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	Gpr39	IMP	MGI:MGI:3701833	Mouse	PMID:23133519
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	Gpr39	IMP		Mouse	PMID:26375174
Biological Process	GO:0030641	regulation of cellular pH	Gpr39	IMP		Mouse	PMID:26375174
Biological Process	GO:0019216	regulation of lipid metabolic process	Gpr39	IMP	MGI:MGI:3701833	Mouse	PMID:21784784
Biological Process	GO:0042391	regulation of membrane potential	Gpr39	IGI	MGI:MGI:2142149	Mouse	PMID:23133519
Biological Process	GO:0042391	regulation of membrane potential	Gpr39	IMP	MGI:MGI:3701833	Mouse	PMID:23133519
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Gpr39	IMP	MGI:MGI:3701833	Mouse	PMID:23133519

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern