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Gpr39 Gene Detail
Summary
  • Symbol
    Gpr39
  • Name
    G protein-coupled receptor 39
  • Synonyms
    4933415E13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918361
    NCBI Gene: 71111
  • Gene Overview
    MyGene.info: GPR39
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:125676996-125873862 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 54.70 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2604 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918361
protein coding gene Chr1:125676995-125873862 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016416
protein coding gene Chr1:128774543-128986523 (+)
A/J MGP_AJ_G0016399
protein coding gene Chr1:124040083-124239441 (+)
AKR/J MGP_AKRJ_G0016364
protein coding gene Chr1:127667063-127868252 (+)
BALB/cJ MGP_BALBcJ_G0016359
protein coding gene Chr1:124390284-124596299 (+)
C3H/HeJ MGP_C3HHeJ_G0016185
protein coding gene Chr1:127865611-128072824 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016820
protein coding gene Chr1:133645244-133858373 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014533
protein coding gene Chr1:117438605-117641947 (+)
CAST/EiJ MGP_CASTEiJ_G0015766
protein coding gene Chr1:126779256-126994518 (+)
CBA/J MGP_CBAJ_G0016158
protein coding gene Chr1:138144969-138350411 (+)
DBA/2J MGP_DBA2J_G0016264
protein coding gene Chr1:123042078-123243359 (+)
FVB/NJ MGP_FVBNJ_G0016263
protein coding gene Chr1:121783025-121984866 (+)
LP/J MGP_LPJ_G0016335
protein coding gene Chr1:130117685-130329028 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016288
protein coding gene Chr1:144094917-144314463 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016856
protein coding gene Chr1:127438111-127644865 (+)
PWK/PhJ MGP_PWKPhJ_G0015552
protein coding gene Chr1:122018757-122221215 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015340
protein coding gene Chr1:126365264-126588650 (+)
WSB/EiJ MGP_WSBEiJ_G0015828
protein coding gene Chr1:127387233-127597204 (+)



Homology
more
  • Human Ortholog
    GPR39, G protein-coupled receptor 39
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GPR39, G protein-coupled receptor 39
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 2863
    neXtProt AC: NX_O43194
    UniProt: O43194

  • Chr Location
    2q21.2; chr2:132415972-132646596 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display abnormal glucose homeostasis when fed a high sugar diet. Mice homozygous for a different null allele have accelerated gastric emptying, decreased fasting-induced hyperphagia, and increasedbody weight after oneyear of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 71111 NCBI Gene Model | MGI Sequence Detail 196867 C57BL/6J ±  kb
transcript NM_027677 RefSeq | MGI Sequence Detail 2690 C57BL/6  
polypeptide Q5U431 UniProt | EBI | MGI Sequence Detail 456 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 5
    cDNA 4
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:257542 Yang Q, et al., Zac1/GPR39 phosphorylating CaMK-II contributes to the distinct roles of Pax3 and Pax7 in myogenic progression. Biochim Biophys Acta. 2018 Feb;1864(2):407-419

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory