Gpr39 MGI Mouse Gene Detail - MGI:1918361 - G protein-coupled receptor 39

Symbol

Gpr39
Name

G protein-coupled receptor 39
Synonyms

4933415E13Rik

Feature Type

protein coding gene
IDs

MGI:1918361
NCBI Gene: 71111
Alliance

genome feature page
Transcription Start Sites

15 TSS

Sequence Map

Chr1:125604732-125801599 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 54.70 cM, cytoband E3
Mapping Data

2 experiments

SNPs within 2kb

6206 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918361	protein coding gene	Chr1:125604725-125804132 (+)
129S1/SvImJ	ENSMUSG00200007151	protein coding gene	Chr1:123173475-123373029 (+)
A/J	ENSMUSG00195038067	protein coding gene	Chr1:122258451-122455764 (+)
AKR/J	ENSMUSG00220024200	protein coding gene	Chr1:122113029-122310360 (+)
BALB/cJ	ENSMUSG00180036373	protein coding gene	Chr1:122835211-123032473 (+)
C3H/HeJ	ENSMUSG00175045069	protein coding gene	Chr1:122540315-122737583 (+)
C57BL/6NJ	ENSMUSG00215043138	protein coding gene	Chr1:122523829-122720907 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014533	protein coding gene	Chr1:117438605-117641947 (+)
CAST/EiJ	ENSTCUG00005006081	protein coding gene	Chr1:121469248-121666907 (+)
CBA/J	ENSMUSG00210027200	protein coding gene	Chr1:122385052-122582306 (+)
DBA/2J	ENSMUSG00185002014	protein coding gene	Chr1:126774170-126971480 (+)
FVB/NJ	ENSMUSG00205041368	protein coding gene	Chr1:121852369-122051646 (+)
JF1/MsJ	ENSUMUG00000001726	protein coding gene	Chr1:125937399-126140480 (+)
LP/J	no annotation
NOD/ShiLtJ	ENSMUSG00190035031	protein coding gene	Chr1:122404085-122603321 (+)
NZO/HlLtJ	ENSMUSG00225004359	protein coding gene	Chr1:130076590-130275606 (+)
PWK/PhJ	ENSLUMG00010014062	protein coding gene	Chr1:121555272-121752936 (+)
SPRET/EiJ	ENSMSPG00010042545	protein coding gene	Chr1:124257465-124463862 (+)
WSB/EiJ	ENSIUOG00005046655	protein coding gene	Chr1:122149871-122348958 (+)

Human Ortholog

GPR39, G protein-coupled receptor 39

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR39, G protein-coupled receptor 39
Synonyms

ZnR
Links

HGNC:4496

NCBI Gene ID: 2863

UniProt: O43194
Chr Location

2q21.2; chr2:132416805-132646582 (+) GRCh38

MGI Vertebrate Homology

Gpr39 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPR39
Gene Tree

Gpr39

less

Phenotype Summary

19 phenotypes from 4 alleles in 4 genetic backgrounds
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

2
Endonuclease-mediated

11
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Gpr39
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display abnormal glucose homeostasis when fed a high sugar diet. Mice homozygous for a different null allele have accelerated gastric emptying, decreased fasting-induced hyperphagia, and increasedbody weight after oneyear of age.

less

All GO Annotations

36
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN gpr39

less

All Sequences

35
RefSeq

2
UniProt

4
CCDS

CCDS48344.1

Ensembl

ENSMUSG00000026343 (Evidence)
NCBI Gene

71111

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026343	Ensembl Gene Model \| MGI Sequence Detail	196868	C57BL/6J	± kb
transcript	ENSMUST00000027581	Ensembl \| MGI Sequence Detail	2691	Not Applicable
polypeptide	ENSMUSP00000027581	Ensembl \| MGI Sequence Detail	456	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000001532 G-protein coupled receptor 39

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR052676 Zinc-sensing G-protein coupled receptor
GlyGen

Q5U431 2 sites

less

All nucleic 5

cDNA 4

Primer pair 1

Microarray probesets 3

Summaries

All 68

Gene Ontology 13

Phenotypes 33
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:388238 Bai HH, et al., Enhanced expression of spinal PTP1B contributes to peripheral inflammation- induced glycinergic disinhibition and mechanical pain. Commun Biol. 2026 May 20;

TSS for Gpr39:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8444	Chr1:125604585-125604592 (+)	-143 bp
Tssr8445	Chr1:125604598-125604611 (+)	-127 bp
Tssr8446	Chr1:125604622-125604632 (+)	-105 bp
Tssr8447	Chr1:125604706-125604752 (+)	-3 bp
Tssr8448	Chr1:125604757-125604812 (+)	53 bp
Tssr189	Chr1:125604832-125604839 (+)	104 bp
Tssr8449	Chr1:125604850-125604859 (+)	123 bp
Tssr8450	Chr1:125604868-125604879 (+)	142 bp
Tssr8451	Chr1:125604893-125604905 (+)	167 bp
Tssr8452	Chr1:125604933-125604946 (+)	208 bp
Tssr8453	Chr1:125604955-125604970 (+)	231 bp
Tssr8454	Chr1:125605024-125605039 (+)	300 bp
Tssr8455	Chr1:125605413-125605424 (+)	687 bp
Tssr8456	Chr1:125707764-125707768 (+)	103,034 bp
Tssr8457	Chr1:125767697-125767709 (+)	162,971 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24