Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GPR143
  • Mouse genes Gpr143
  • Rat genes Gpr143
  • Zfish genes gpr143
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gpr143

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035240	dopamine binding	GPR143	IDA		Human	PMID:18828673
Molecular Function	GO:0004930	G protein-coupled receptor activity	GPR143	IDA		Human	PMID:16524428
Molecular Function	GO:0072544	L-DOPA binding	GPR143	IDA		Human	PMID:18828673
Molecular Function	GO:0035643	L-DOPA receptor activity	GPR143	IDA		Human	PMID:18828673
Molecular Function	GO:0005515	protein binding	GPR143	IPI	UniProtKB:P32121	Human	PMID:16524428
Molecular Function	GO:0005515	protein binding	GPR143	IPI	UniProtKB:P49407	Human	PMID:16524428
Molecular Function	GO:0005515	protein binding	GPR143	IPI	UniProtKB:Q16655	Human	PMID:19717472
Molecular Function	GO:0005515	protein binding	GPR143	IPI	UniProtKB:P14679	Human	PMID:27720922
Molecular Function	GO:0072545	tyrosine binding	GPR143	IDA		Human	PMID:18828673
Cellular Component	GO:0016324	apical plasma membrane	GPR143	IDA		Human	PMID:18828673
Cellular Component	GO:0005794	Golgi apparatus	GPR143	IDA		Human	PMID:19717472
Cellular Component	GO:0005765	lysosomal membrane	GPR143	IDA		Human	PMID:16621890
Cellular Component	GO:0042470	melanosome	GPR143	IDA		Human	PMID:10471510
Cellular Component	GO:0033162	melanosome membrane	GPR143	IDA		Human	PMID:16621890
Cellular Component	GO:0005886	plasma membrane	GPR143	IDA		Human	PMID:16524428
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	GPR143	IDA		Human	PMID:18828673
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	GPR143	IDA		Human	PMID:16524428
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	GPR143	IMP		Human	PMID:18828673
Biological Process	GO:0032400	melanosome localization	GPR143	IDA		Human	PMID:19717472
Biological Process	GO:0032438	melanosome organization	GPR143	IMP		Human	PMID:19717472
Biological Process	GO:0032438	melanosome organization	gpr143	IMP	ZFIN:ZDB-MRPHLNO-150618-2	Zfish	PMID:25690007
Biological Process	GO:0032402	melanosome transport	GPR143	IDA		Human	PMID:19717472
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	GPR143	IDA		Human	PMID:16524428
Biological Process	GO:0050848	regulation of calcium-mediated signaling	GPR143	IDA		Human	PMID:18828673
Biological Process	GO:1903056	regulation of melanosome organization	Gpr143	IMP		Mouse	MGI:MGI:3813974|PMID:18697795
Biological Process	GO:1902908	regulation of melanosome transport	Gpr143	IMP		Mouse	MGI:MGI:3813974|PMID:18697795

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern