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Gpr143
Gene Detail
Symbol

Name
ID
Gpr143
G protein-coupled receptor 143
MGI:107193
Synonyms
Oa1
Feature Type
protein coding gene
Genetic Map
Chromosome X
68.46 cM, cytoband F2-F3
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
ChrX:152781921-152808646 bp, + strand
From VEGA annotation of GRCm38

  26726 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:230  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gpr143

Human
homologs
Human Homolog GPR143, G protein-coupled receptor 143
NCBI Gene ID 4935
neXtProt AC  NX_P51810
Human Synonyms  NYS6, OA1
Human Chr (Location)  Xp22.3; chrX:9725413-9765965 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human GPR143
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Hemizygous males exhibit hypopigmentation of the ocular fundus, misrouting of the optic fibers at the chiasm, and the presence of giant melanosomes in the pigment epithelium of the eye.
 
Human Diseases Modeled Using Mouse Gpr143 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Gpr143 interacts with 71 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (22)    Tissues (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 21
RT-PCR 1
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(6) cDNA(13) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000019341 (Evidence)
Ensembl Gene ModelENSMUSG00000025333 (Evidence)
Entrez Gene18241 (Evidence)
UniGene5157
DFCITC1585947
DoTSDT.111030622, DT.87034950
NIA Mouse Gene IndexU020334
Consensus CDS ProjectCCDS30476.1
International Mouse Knockout Project StatusGpr143
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019341 VEGA Gene Model | MGI Sequence Detail 26726 C57BL/6J ±  kb
transcript OTTMUST00000046178 VEGA | MGI Sequence Detail 1586 Not Applicable 
polypeptide OTTMUSP00000020865 VEGA | MGI Sequence Detail 405 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(124 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001414 Ocular albinism protein, type 1
Protein Ontology PR:000008186 G-protein coupled receptor 143
References
(Earliest) J:33821 Dinulos MB, et al., A new region of conservation is defined between human and mouse X chromosomes. Genomics. 1996 Jul 1;35(1):244-7
(Latest) J:191882 Rachel RA, et al., Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis. PLoS One. 2012;7(9):e42446
All references(46)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35654

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory