Gpr143
Gene Detail

Symbol Name ID

Gpr143 G protein-coupled receptor 143 MGI:107193

Synonyms

Oa1

Feature Type

protein coding gene

Genetic Map

Chromosome X

68.46 cM, cytoband F2-F3
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

ChrX:152781921-152808646 bp, + strand From VEGA annotation of GRCm38   26726 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:230  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Gpr143

Human homologs

Human Homolog		GPR143, G protein-coupled receptor 143
NCBI Gene ID		4935
neXtProt AC		NX_P51810
Human Synonyms		NYS6, OA1
Human Chr (Location)		Xp22.3; chrX:9693453-9734005 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human GPR143

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Hemizygous males exhibit hypopigmentation of the ocular fundus, misrouting of the optic fibers at the chiasm, and the presence of giant melanosomes in the pigment epithelium of the eye.

 
Human Diseases Modeled Using Mouse Gpr143 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	calcium-mediated signaling using intracellular calcium source, G-protein coupled receptor signaling pathway, ...
Component	apical plasma membrane, Golgi apparatus, ...
Function	dopamine binding, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (22)    Tissues (10)   
Theiler Stages: 17, 19, 28

Assay Type	Results
Northern blot	21
RT-PCR	1

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(6) cDNA(13) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000019341 (Evidence)
Ensembl Gene Model	ENSMUSG00000025333 (Evidence)
Entrez Gene	18241 (Evidence)
UniGene	5157
DFCI	TC1585947
DoTS	DT.111030622, DT.87034950
NIA Mouse Gene Index	U020334
Consensus CDS Project	CCDS30476.1
International Mouse Knockout Project Status	Gpr143

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019341	VEGA Gene Model | MGI Sequence Detail	26726	C57BL/6J
transcript	OTTMUST00000046178	VEGA | MGI Sequence Detail	1586	Not Applicable
polypeptide	OTTMUSP00000020865	VEGA | MGI Sequence Detail	405	Not Applicable

All sequences(26) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(105 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001414	Ocular albinism protein, type 1
Protein Ontology	PR:000008186	G-protein coupled receptor 143

References

(Earliest) J:33821 Dinulos MB, et al., A new region of conservation is defined between human and mouse X chromosomes. Genomics. 1996 Jul 1;35(1):244-7
(Latest) J:191882 Rachel RA, et al., Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis. PLoS One. 2012;7(9):e42446
All references(46)

Other accession IDs

MGD-MRK-35654