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Gpr143tm1Inc
Targeted Allele Detail
Summary
Symbol: Gpr143tm1Inc
Name: G protein-coupled receptor 143; targeted mutation 1, Barbara Incerti
MGI ID: MGI:1931862
Synonyms: Oa1-
Gene: Gpr143  Location: ChrX:151564917-151591642 bp, + strand  Genetic Position: ChrX, 68.46 cM, cytoband F2-F3
Alliance: Gpr143tm1Inc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66139
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-hprt expression cassette replaced exon 1 including the start codon of the gene. Several human mutations are located in the corresponding human exon 1. Northern analysis of primary melanocyte cultures did not detect transcript in homozygous mutant neonates. (J:66139)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gpr143 Mutation:  13 strains or lines available
References
Original:  J:66139 Incerti B, et al., Oa1 knock-out: new insights on the pathogenesis of ocular albinism type 1. Hum Mol Genet. 2000 Nov 22;9(19):2781-8
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory