Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GALC
  • Mouse genes Galc
  • Rat genes Galc
  • Zfish genes galca,galcb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Galc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004336	galactosylceramidase activity	GALC	IDA		Human	PMID:8281145
Molecular Function	GO:0004336	galactosylceramidase activity	GALC	IDA		Human	PMID:8399327
Molecular Function	GO:0004336	galactosylceramidase activity	Galc	IDA		Mouse	MGI:MGI:78941|PMID:8769874
Molecular Function	GO:0004336	galactosylceramidase activity	Galc	IMP	MGI:MGI:1856218	Mouse	PMID:11371512
Molecular Function	GO:0004336	galactosylceramidase activity	Galc	IMP	MGI:MGI:1856218	Mouse	PMID:11734583
Molecular Function	GO:0004336	galactosylceramidase activity	Galc	IDA		Mouse	PMID:11371512
Molecular Function	GO:0004336	galactosylceramidase activity	galcb	IDA		Zfish	PMID:24463171
Molecular Function	GO:0004336	galactosylceramidase activity	galca	IDA		Zfish	PMID:24463171
Cellular Component	GO:0005764	lysosome	galcb	IDA		Zfish	PMID:24463171
Cellular Component	GO:0005764	lysosome	galca	IDA		Zfish	PMID:24463171
Cellular Component	GO:0005739	mitochondrion	Galc	HDA		Mouse	PMID:18614015
Biological Process	GO:0006683	galactosylceramide catabolic process	GALC	IDA		Human	PMID:8399327
Biological Process	GO:0006683	galactosylceramide catabolic process	Galc	IMP		Mouse	MGI:MGI:78941|PMID:8769874
Biological Process	GO:0006683	galactosylceramide catabolic process	Galc	IMP	MGI:MGI:1856218	Mouse	PMID:11371512
Biological Process	GO:0006683	galactosylceramide catabolic process	Galc	IDA		Mouse	PMID:11371512
Biological Process	GO:0042552	myelination	Galc	IMP	MGI:MGI:1856218	Mouse	PMID:11371512

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern