Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GAB2
  • Mouse genes Gab2
  • Rat genes Gab2
  • Zfish genes gab2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gab2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	Gab2	IDA		Mouse	MGI:MGI:3768863|PMID:16456001
Molecular Function	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	Gab2	IDA		Mouse	MGI:MGI:3768863|PMID:16456001
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:Q06124	Human	PMID:15170389
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:Q9Y6Q6	Human	PMID:15750601
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P00533	Human	PMID:16253990
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P62993	Human	PMID:16253990
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:Q06124	Human	PMID:16253990
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P00533	Human	PMID:19172738
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P27348	Human	PMID:19172738
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P29353	Human	PMID:19172738
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P31946	Human	PMID:19172738
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P31947	Human	PMID:19172738
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P61981	Human	PMID:19172738
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P62258	Human	PMID:19172738
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P62993	Human	PMID:19172738
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P63104	Human	PMID:19172738
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:Q04917	Human	PMID:19172738
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:Q06124	Human	PMID:19172738
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P62993	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P62993	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P62993	Human	PMID:21706016
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P62993	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P62993	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P00533	Human	PMID:31585087
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P62993	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:A0A024R8L2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:O75791	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P62993	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P08865	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P11117	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	GAB2	IPI	UniProtKB:Q8WZ73-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Gab2	IPI	UniProtKB:Q9Y6Q6	Mouse	MGI:MGI:3575591|PMID:15750601
Molecular Function	GO:0005515	protein binding	Gab2	IPI	UniProtKB:P25911|UniProtKB:P29351	Mouse	MGI:MGI:3837242|PMID:19171907
Molecular Function	GO:0005515	protein binding	Gab2	IPI	UniProtKB:P48025	Mouse	MGI:MGI:3768863|PMID:16456001
Molecular Function	GO:0019904	protein domain specific binding	Gab2	IPI	RGD:3447|RGD:3329|RGD:619758	Rat	PMID:10973965|RGD:2303503
Molecular Function	GO:0019903	protein phosphatase binding	Gab2	IPI	RGD:3447	Rat	PMID:12959980|RGD:12743580
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	GAB2	IDA		Human	PMID:19172738
Cellular Component	GO:0005737	cytoplasm	GAB2	IDA		Human	PMID:19172738
Cellular Component	GO:0005886	plasma membrane	GAB2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	GAB2	IDA		Human	PMID:19172738
Cellular Component	GO:0032991	protein-containing complex	Gab2	IDA		Rat	PMID:10973965|RGD:2303503
Biological Process	GO:0016477	cell migration	Gab2	IDA		Mouse	PMID:11895767
Biological Process	GO:0007229	integrin-mediated signaling pathway	Gab2	IDA		Mouse	PMID:11895767
Biological Process	GO:0035556	intracellular signal transduction	Gab2	IDA		Rat	PMID:10973965|RGD:2303503
Biological Process	GO:0030316	osteoclast differentiation	GAB2	IMP		Human	PMID:15750601
Biological Process	GO:0030316	osteoclast differentiation	Gab2	IMP		Mouse	MGI:MGI:3575591|PMID:15750601
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	Gab2	IMP		Mouse	MGI:MGI:2137187|PMID:11449275
Biological Process	GO:0008284	positive regulation of cell population proliferation	GAB2	IDA		Human	PMID:19172738
Biological Process	GO:0010634	positive regulation of epithelial cell migration	Gab2	IMP		Mouse	MGI:MGI:5525983|PMID:23401857
Biological Process	GO:0043306	positive regulation of mast cell degranulation	Gab2	IMP		Mouse	MGI:MGI:2137187|PMID:11449275

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern