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Gab2 Gene Detail
Summary
  • Symbol
    Gab2
  • Name
    growth factor receptor bound protein 2-associated protein 2
  • Synonyms
    D130058I17Rik, p97
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333854
    NCBI Gene: 14389
  • Gene Overview
    MyGene.info: GAB2
Location & Maps
more
  • Sequence Map
    Chr7:97081586-97308946 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      227361 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 53.39 cM, cytoband E2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GAB2, GRB2 associated binding protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GAB2, GRB2 associated binding protein 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 9846
    neXtProt AC: NX_Q9UQC2

  • Chr Location
    11q14.1; chr11:78215290-78417822 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 69067
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: GAB2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 7 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    9
  • Genomic Mutations
    3 involving Gab2
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit impairments in passive cutaneous and systemic anaphylaxis, Fc gamma receptor-mediated phagocytosis, and mast cell development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058176 VEGA Gene Model | MGI Sequence Detail 227361 C57BL/6J ±  kb
transcript OTTMUST00000142867 VEGA | MGI Sequence Detail 6168 Not Applicable  
polypeptide OTTMUSP00000074496 VEGA | MGI Sequence Detail 666 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    768 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000007754 GRB2-associated-binding protein 2
  • InterPro Domains
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
Molecular
Reagents
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  • All nucleic 43
    cDNA 42
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGI:2141977, MGI:2441947
References
more
  • Summaries
    All 61
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 50
  • Earliest
    J:51807 Gu H, et al., Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Mol Cell. 1998 Dec;2(6):729-40
  • Latest
    J:232642 Gu S, et al., Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1. Blood. 2016 Apr 7;127(14):1803-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory