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Gab2 Gene Detail
Summary
  • Symbol
    Gab2
  • Name
    growth factor receptor bound protein 2-associated protein 2
  • Synonyms
    D130058I17Rik, p97
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333854
    NCBI Gene: 14389
  • Gene Overview
    MyGene.info: GAB2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:97081586-97308946 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      227361 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 53.39 cM, cytoband E2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GAB2, GRB2 associated binding protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GAB2, GRB2 associated binding protein 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 9846
    neXtProt AC: NX_Q9UQC2
    UniProt: Q9UQC2

  • Chr Location
    11q14.1; chr11:78215290-78417822 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 69067
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GAB2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 7 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impairments in passive cutaneous and systemic anaphylaxis, Fc gamma receptor-mediated phagocytosis, and mast cell development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000058176 VEGA Gene Model | MGI Sequence Detail 227361 C57BL/6J ±  kb
    transcript OTTMUST00000142867 VEGA | MGI Sequence Detail 6168 Not Applicable  
    polypeptide OTTMUSP00000074496 VEGA | MGI Sequence Detail 666 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      768 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 42
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141977, MGI:2441947
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 53
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:248195 Shin YK, et al., Cooperative interaction of hepatocyte growth factor and neuregulin regulates Schwann cell migration and proliferation through Grb2-associated binder-2 in peripheral nerve repair. Glia. 2017 Nov;65(11):1794-1808

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory