Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FLOT1
  • Mouse genes Flot1
  • Rat genes Flot1
  • Zfish genes flot1a,flot1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Flot1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	Flot1	IPI	RGD:2737|RGD:2738|RGD:2736	Rat	PMID:19298817|RGD:2326007
Molecular Function	GO:0002020	protease binding	FLOT1	IPI	UniProtKB:P56817	Human	PMID:24612608
Molecular Function	GO:0002020	protease binding	Flot1	IPI	UniProtKB:P56817	Rat	PMID:24612608|RGD:8693369
Molecular Function	GO:0005515	protein binding	FLOT1	IPI	UniProtKB:O95477	Human	PMID:15469992
Molecular Function	GO:0005515	protein binding	FLOT1	IPI	UniProtKB:P05067	Human	PMID:16480949
Molecular Function	GO:0005515	protein binding	FLOT1	IPI	UniProtKB:Q14254	Human	PMID:17113085
Molecular Function	GO:0005515	protein binding	FLOT1	IPI	UniProtKB:Q9HAQ2	Human	PMID:21119006
Molecular Function	GO:0005515	protein binding	FLOT1	IPI	UniProtKB:Q14254	Human	PMID:21696602
Molecular Function	GO:0005515	protein binding	FLOT1	IPI	UniProtKB:Q14254	Human	PMID:24167781
Molecular Function	GO:0005515	protein binding	FLOT1	IPI	UniProtKB:Q14254	Human	PMID:24809731
Molecular Function	GO:0005515	protein binding	FLOT1	IPI	UniProtKB:P42858	Human	PMID:25959826
Molecular Function	GO:0005515	protein binding	FLOT1	IPI	UniProtKB:Q14254	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	FLOT1	IPI	UniProtKB:P54852	Human	PMID:30614533
Molecular Function	GO:0005515	protein binding	FLOT1	IPI	UniProtKB:P10606	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FLOT1	IPI	UniProtKB:Q68D86	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FLOT1	IPI	UniProtKB:Q86YD7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FLOT1	IPI	UniProtKB:Q8N9N5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FLOT1	IPI	UniProtKB:Q9Y5B8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FLOT1	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Flot1	IPI	UniProtKB:Q62417	Mouse	MGI:MGI:3690172|PMID:11001060
Molecular Function	GO:0005515	protein binding	Flot1	IPI	PR:P15208	Mouse	PMID:16455755
Molecular Function	GO:0005515	protein binding	Flot1	IPI	PR:P22682	Mouse	PMID:16455755
Molecular Function	GO:0005515	protein binding	Flot1	IPI	PR:P14142	Mouse	PMID:16455755
Molecular Function	GO:0005515	protein binding	Flot1	IPI	PR:Q64010	Mouse	PMID:16455755
Molecular Function	GO:0005515	protein binding	Flot1	IPI	RGD:70993	Rat	PMID:19298817|RGD:2326007
Cellular Component	GO:0005912	adherens junction	FLOT1	IDA		Human	PMID:24046456
Cellular Component	GO:0016323	basolateral plasma membrane	FLOT1	IDA		Human	PMID:23983584
Cellular Component	GO:0005901	caveola	Flot1	IDA		Mouse	PMID:9153235
Cellular Component	GO:0005901	caveola	Flot1	IDA		Rat	PMID:17982011|RGD:8554071
Cellular Component	GO:0005901	caveola	Flot1	IDA		Rat	PMID:9858255|RGD:70739
Cellular Component	GO:0044291	cell-cell contact zone	FLOT1	IDA		Human	PMID:23983584
Cellular Component	GO:0005911	cell-cell junction	FLOT1	IDA		Human	PMID:25468996
Cellular Component	GO:0034451	centriolar satellite	FLOT1	IDA		Human	PMID:18000879
Cellular Component	GO:0030864	cortical actin cytoskeleton	FLOT1	IDA		Human	PMID:24046456
Cellular Component	GO:0031410	cytoplasmic vesicle	FLOT1	IDA		Human	PMID:23983584
Cellular Component	GO:0098691	dopaminergic synapse	FLOT1	IDA		Human	PMID:21399631
Cellular Component	GO:0098691	dopaminergic synapse	FLOT1	IMP		Human	PMID:21399631
Cellular Component	GO:0005769	early endosome	FLOT1	IDA		Human	PMID:21399631
Cellular Component	GO:0005768	endosome	FLOT1	IDA		Human	PMID:20682791
Cellular Component	GO:0009897	external side of plasma membrane	Flot1	IDA		Mouse	PMID:25429154
Cellular Component	GO:0070062	extracellular exosome	FLOT1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	FLOT1	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	FLOT1	HDA		Human	PMID:23533145
Cellular Component	GO:0016600	flotillin complex	FLOT1	IDA		Human	PMID:21399631
Cellular Component	GO:0016600	flotillin complex	FLOT1	IDA		Human	PMID:21696602
Cellular Component	GO:0016600	flotillin complex	FLOT1	IDA		Human	PMID:24046456
Cellular Component	GO:0016600	flotillin complex	FLOT1	IDA		Human	PMID:25204797
Cellular Component	GO:0016600	flotillin complex	Flot1	IDA		Mouse	MGI:MGI:5634880|PMID:24046456
Cellular Component	GO:0016600	flotillin complex	Flot1	IDA		Mouse	MGI:MGI:3690172|PMID:11001060
Cellular Component	GO:0016600	flotillin complex	Flot1	IDA		Rat	PMID:9858255|RGD:70739
Cellular Component	GO:0005925	focal adhesion	FLOT1	HDA		Human	PMID:21423176
Cellular Component	GO:0098982	GABA-ergic synapse	Flot1	EXP		Rat	PMID:23622064|RGD:13702180
Cellular Component	GO:0098982	GABA-ergic synapse	Flot1	IDA		Rat	PMID:23622064|RGD:13702180
Cellular Component	GO:0098978	glutamatergic synapse	Flot1	IDA		Rat	PMID:20669324|RGD:13702260
Cellular Component	GO:0098978	glutamatergic synapse	Flot1	EXP		Rat	PMID:23622064|RGD:13702180
Cellular Component	GO:0098978	glutamatergic synapse	Flot1	IDA		Rat	PMID:23622064|RGD:13702180
Cellular Component	GO:0030027	lamellipodium	FLOT1	IDA		Human	PMID:24046456
Cellular Component	GO:0005765	lysosomal membrane	FLOT1	HDA		Human	PMID:17897319
Cellular Component	GO:0016020	membrane	FLOT1	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Flot1	IDA		Mouse	PMID:16455755
Cellular Component	GO:0016020	membrane	Flot1	IDA		Mouse	PMID:21413931
Cellular Component	GO:0045121	membrane raft	FLOT1	IDA		Human	PMID:15469992
Cellular Component	GO:0045121	membrane raft	FLOT1	IDA		Human	PMID:25893292
Cellular Component	GO:0045121	membrane raft	Flot1	IDA		Mouse	PMID:19144954
Cellular Component	GO:0045121	membrane raft	Flot1	IDA		Mouse	PMID:12388596
Cellular Component	GO:0005815	microtubule organizing center	FLOT1	IDA		Human	PMID:18000879
Cellular Component	GO:0005886	plasma membrane	FLOT1	IDA		Human	PMID:21399631
Cellular Component	GO:0005886	plasma membrane	FLOT1	IMP		Human	PMID:21696602
Cellular Component	GO:0005886	plasma membrane	Flot1	IDA		Mouse	PMID:12370178
Cellular Component	GO:0044853	plasma membrane raft	Flot1	IDA		Mouse	MGI:MGI:5634880|PMID:24046456
Cellular Component	GO:0098793	presynapse	Flot1	IDA		Rat	PMID:12591123|RGD:13702179
Cellular Component	GO:0048786	presynaptic active zone	Flot1	EXP		Rat	PMID:23622064|RGD:13702180
Cellular Component	GO:0048786	presynaptic active zone	Flot1	IDA		Rat	PMID:23622064|RGD:13702180
Cellular Component	GO:0042383	sarcolemma	Flot1	IDA		Mouse	PMID:16455755
Cellular Component	GO:0045202	synapse	Flot1	IDA		Rat	PMID:20669324|RGD:13702260
Cellular Component	GO:0001931	uropod	FLOT1	IDA		Human	PMID:21696602
Biological Process	GO:0007409	axonogenesis	Flot1	IMP		Mouse	PMID:19458231
Biological Process	GO:0071360	cellular response to exogenous dsRNA	FLOT1	IMP		Human	PMID:25204797
Biological Process	GO:0033227	dsRNA transport	FLOT1	IMP		Human	PMID:25204797
Biological Process	GO:0022617	extracellular matrix disassembly	FLOT1	IMP		Human	PMID:21119006
Biological Process	GO:0044854	plasma membrane raft assembly	FLOT1	IMP		Human	PMID:21399631
Biological Process	GO:0044857	plasma membrane raft organization	FLOT1	IMP		Human	PMID:25204797
Biological Process	GO:1901890	positive regulation of cell junction assembly	FLOT1	IMP		Human	PMID:24046456
Biological Process	GO:1901890	positive regulation of cell junction assembly	Flot1	IMP		Mouse	MGI:MGI:5634880|PMID:24046456
Biological Process	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	FLOT1	IMP		Human	PMID:24046456
Biological Process	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	Flot1	IMP		Mouse	MGI:MGI:5634880|PMID:24046456
Biological Process	GO:0001819	positive regulation of cytokine production	FLOT1	IMP		Human	PMID:25204797
Biological Process	GO:0045807	positive regulation of endocytosis	FLOT1	IMP		Human	PMID:21399631
Biological Process	GO:0045807	positive regulation of endocytosis	Flot1	IMP		Mouse	MGI:MGI:5634885|PMID:21399631
Biological Process	GO:0034116	positive regulation of heterotypic cell-cell adhesion	FLOT1	IMP		Human	PMID:25204797
Biological Process	GO:0032728	positive regulation of interferon-beta production	FLOT1	IMP		Human	PMID:25204797
Biological Process	GO:1901741	positive regulation of myoblast fusion	FLOT1	IMP		Human	PMID:24046456
Biological Process	GO:1901741	positive regulation of myoblast fusion	Flot1	IMP		Mouse	MGI:MGI:5634880|PMID:24046456
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	FLOT1	IMP		Human	PMID:23319823
Biological Process	GO:0032092	positive regulation of protein binding	FLOT1	IMP		Human	PMID:24046456
Biological Process	GO:0032092	positive regulation of protein binding	Flot1	IMP		Mouse	MGI:MGI:5634880|PMID:24046456
Biological Process	GO:0001934	positive regulation of protein phosphorylation	FLOT1	IMP		Human	PMID:25204797
Biological Process	GO:0048643	positive regulation of skeletal muscle tissue development	FLOT1	IMP		Human	PMID:24046456
Biological Process	GO:0048643	positive regulation of skeletal muscle tissue development	Flot1	IMP		Mouse	MGI:MGI:5634880|PMID:24046456
Biological Process	GO:0032226	positive regulation of synaptic transmission, dopaminergic	Flot1	IMP		Mouse	MGI:MGI:5634885|PMID:21399631
Biological Process	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	FLOT1	IMP		Human	PMID:25204797
Biological Process	GO:0070528	protein kinase C signaling	FLOT1	IMP		Human	PMID:21399631
Biological Process	GO:0070528	protein kinase C signaling	Flot1	IMP		Mouse	MGI:MGI:5634885|PMID:21399631
Biological Process	GO:0072659	protein localization to plasma membrane	FLOT1	IMP		Human	PMID:24046456
Biological Process	GO:0072659	protein localization to plasma membrane	FLOT1	IMP		Human	PMID:24612608
Biological Process	GO:0072659	protein localization to plasma membrane	Flot1	IMP		Mouse	MGI:MGI:5634880|PMID:24046456
Biological Process	GO:0072659	protein localization to plasma membrane	Flot1	IMP		Mouse	PMID:16455755
Biological Process	GO:0050821	protein stabilization	FLOT1	IMP		Human	PMID:25204797
Biological Process	GO:0051580	regulation of neurotransmitter uptake	FLOT1	IDA		Human	PMID:21399631
Biological Process	GO:0051580	regulation of neurotransmitter uptake	FLOT1	IMP		Human	PMID:21399631
Biological Process	GO:0002090	regulation of receptor internalization	FLOT1	IMP		Human	PMID:21399631
Biological Process	GO:0002090	regulation of receptor internalization	Flot1	IMP		Mouse	MGI:MGI:5634885|PMID:21399631
Biological Process	GO:0035023	regulation of Rho protein signal transduction	Flot1	IMP		Mouse	PMID:19458231
Biological Process	GO:0034976	response to endoplasmic reticulum stress	FLOT1	IMP		Human	PMID:25204797

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern