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Flot1 Gene Detail
Summary
  • Symbol
    Flot1
  • Name
    flotillin 1
  • Synonyms
    reggie-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100500
    NCBI Gene: 14251
  • Gene Overview
    MyGene.info: FLOT1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35823320-35832787 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100500
protein coding gene Chr17:35823230-35832791 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023653
protein coding gene Chr17:36017886-36027450 (+)
A/J MGP_AJ_G0023608
protein coding gene Chr17:34902807-34912639 (+)
AKR/J MGP_AKRJ_G0023578
protein coding gene Chr17:35329007-35338590 (+)
BALB/cJ MGP_BALBcJ_G0023613
protein coding gene Chr17:35047100-35056724 (+)
C3H/HeJ MGP_C3HHeJ_G0023379
protein coding gene Chr17:35794337-35803921 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024055
protein coding gene Chr17:37489297-37498848 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021533
protein coding gene Chr17:32598731-32608609 (+)
CAST/EiJ MGP_CASTEiJ_G0022870
protein coding gene Chr17:35905389-35914945 (+)
CBA/J MGP_CBAJ_G0023357
protein coding gene Chr17:39068245-39080332 (+)
DBA/2J MGP_DBA2J_G0023481
protein coding gene Chr17:34209236-34219043 (+)
FVB/NJ MGP_FVBNJ_G0023452
protein coding gene Chr17:34005736-34015291 (+)
LP/J MGP_LPJ_G0023561
protein coding gene Chr17:36398369-36407988 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023473
protein coding gene Chr17:37832946-37848548 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024098
protein coding gene Chr17:35644103-35653609 (+)
PWK/PhJ MGP_PWKPhJ_G0022621
protein coding gene Chr17:33070502-33080376 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022440
protein coding gene Chr17:33691230-33704957 (+)
WSB/EiJ MGP_WSBEiJ_G0022936
protein coding gene Chr17:35792150-35801746 (+)



Homology
more
  • Human Ortholog
    FLOT1, flotillin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FLOT1, flotillin 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 10211
    neXtProt AC: NX_O75955
    UniProt: O75955

  • Chr Location
    6p21.33; chr6:30727709-30742851 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired neutrophil recruitment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14251 NCBI Gene Model | MGI Sequence Detail 9468 C57BL/6J ±  kb
transcript NM_008027 RefSeq | MGI Sequence Detail 1694 C57BL/6  
polypeptide O08917 UniProt | EBI | MGI Sequence Detail 428 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 98
    cDNA 95
    Primer pair 1
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 50
    Developmental Gene Expression 5
    Gene Ontology 15
    Phenotypes 7
  • Earliest
    J:40485 Bickel PE, et al., Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J Biol Chem. 1997 May 23;272(21):13793-802
  • Latest
    J:263557 Riento K, et al., Flotillin proteins recruit sphingosine to membranes and maintain cellular sphingosine-1-phosphate levels. PLoS One. 2018;13(5):e0197401

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory