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Flot1
Gene Detail
Symbol

Name
ID
Flot1
flotillin 1
MGI:1100500
Synonyms
reggie-2
Feature Type
protein coding gene
Genetic Map
Chromosome 17
18.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:35823230-35832791 bp, + strand
From VEGA annotation of GRCm38

  9562 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31337  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Flot1

Human
homologs
Human Homolog FLOT1, flotillin 1
NCBI Gene ID 10211
neXtProt AC  NX_O75955
Human Chr (Location)  6p21.3; chr6:30727734-30742910 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Flot1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired neutrophil recruitment.
 
Interactions
Flot1 interacts with 104 markers (Mir15a, Mir17, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process axon guidance, axonogenesis, ...
Component caveola, centriolar satellite, ...
Function ionotropic glutamate receptor binding, protease binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (162)    Tissues (104)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 162
cDNA source data(94)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(96) cDNA(94) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037406 (Evidence)
Ensembl Gene ModelENSMUSG00000059714 (Evidence)
Entrez Gene14251 (Evidence)
UniGene2931
DFCITC1574499
DoTSDT.493507
NIA Mouse Gene IndexU017918
Consensus CDS ProjectCCDS28705.1
International Mouse Knockout Project StatusFlot1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037406 VEGA Gene Model | MGI Sequence Detail 9562 C57BL/6J ±  kb
transcript OTTMUST00000096512 VEGA | MGI Sequence Detail 1825 Not Applicable 
polypeptide OTTMUSP00000053935 VEGA | MGI Sequence Detail 428 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(14) UniProt(13)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001107 Band 7 protein
Protein Ontology PR:000007558 flotillin-1
References
(Earliest) J:40485 Bickel PE, et al., Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J Biol Chem. 1997 May 23;272(21):13793-802
(Latest) J:186485 Blanc L, et al., Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12099-104
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory