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Flot1
Gene Detail
Symbol

Name
ID
Flot1
flotillin 1
MGI:1100500
Synonyms
reggie-2
Feature Type
protein coding gene
Genetic Map
Chromosome 17
18.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:35823230-35832791 bp, + strand
From VEGA annotation of GRCm38

  9562 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31337  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: FLOT1
Gene Tree: Flot1

Human
homologs
FLOT1, flotillin 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10211
neXtProt AC: NX_O75955

Human Chr (Location): 6p21.3; chr6:30727734-30742685 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Flot1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired neutrophil recruitment.
 
Phenotype Images(1)
Interactions
Flot1 interacts with 104 markers (Mir15a, Mir17, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (74 annotations)
Process axon guidance, axonogenesis, ...
Component basolateral plasma membrane, caveola, ...
Function ionotropic glutamate receptor binding, protease binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (162)    Tissues (104)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 162
cDNA source data(94)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase flot1 ; ZFIN flot1b    NEW 
Molecular
reagents
All nucleic(96) cDNA(94) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037406 (Evidence)
Ensembl Gene Model ENSMUSG00000059714 (Evidence)
Entrez Gene 14251 (Evidence)
UniGene 2931
DFCI TC1574499
DoTS DT.493507
NIA Mouse Gene Index U017918
Consensus CDS Project CCDS28705.1
International Mouse Phenotyping Consortium Status Flot1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037406 VEGA Gene Model | MGI Sequence Detail 9562 C57BL/6J ±  kb
transcript OTTMUST00000096512 VEGA | MGI Sequence Detail 1825 Not Applicable 
polypeptide OTTMUSP00000053935 VEGA | MGI Sequence Detail 428 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(14) UniProt(7)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001107 Band 7 protein
Protein Ontology PR:000007558 flotillin-1
References
(Earliest) J:40485 Bickel PE, et al., Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J Biol Chem. 1997 May 23;272(21):13793-802
(Latest) J:212342 Bitsikas V, et al., The role of flotillins in regulating abeta production, investigated using flotillin 1-/-, flotillin 2-/- double knockout mice. PLoS One. 2014;9(1):e85217
All references(49)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory