Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FGF18
  • Mouse genes Fgf18
  • Rat genes Fgf18
  • Zfish genes fgf18a,fgf18b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fgf18

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005105	type 1 fibroblast growth factor receptor binding	FGF18	IDA		Human	PMID:16384934
Molecular Function	GO:0005111	type 2 fibroblast growth factor receptor binding	FGF18	IDA		Human	PMID:16384934
Cellular Component	GO:0005737	cytoplasm	Fgf18	IDA		Rat	PMID:16756958|RGD:10047366
Cellular Component	GO:0005730	nucleolus	FGF18	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005634	nucleus	Fgf18	IDA		Rat	PMID:16756958|RGD:10047366
Biological Process	GO:0001525	angiogenesis	Fgf18	IMP	MGI:MGI:2178751	Mouse	PMID:17014841
Biological Process	GO:0008283	cell population proliferation	Fgf18	IMP	MGI:MGI:2178751	Mouse	PMID:17014841
Biological Process	GO:0002063	chondrocyte development	Fgf18	IMP	MGI:MGI:2178751	Mouse	PMID:17014841
Biological Process	GO:0002062	chondrocyte differentiation	Fgf18	IGI	MGI:MGI:95524	Mouse	PMID:15781473
Biological Process	GO:0001958	endochondral ossification	Fgf18	IMP	MGI:MGI:2178751	Mouse	PMID:17014841
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Fgf18	IDA		Mouse	PMID:11741978
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Fgf18	IGI	MGI:MGI:95524	Mouse	PMID:15781473
Biological Process	GO:0001957	intramembranous ossification	Fgf18	IMP	MGI:MGI:2178751	Mouse	PMID:17014841
Biological Process	GO:0030324	lung development	Fgf18	IMP	MGI:MGI:2179607	Mouse	PMID:15336546
Biological Process	GO:0007399	nervous system development	Fgf18	IMP		Rat	PMID:9660775|RGD:69834
Biological Process	GO:0001503	ossification	Fgf18	IMP	MGI:MGI:2178751	Mouse	PMID:11937493
Biological Process	GO:0001503	ossification	Fgf18	IMP	MGI:MGI:2179607	Mouse	PMID:11937494
Biological Process	GO:0045766	positive regulation of angiogenesis	FGF18	IGI	RNAcentral:URS00004A5A07_9606	Human	PMID:25449503
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	FGF18	IGI	RNAcentral:URS00004A5A07_9606	Human	PMID:25449503
Biological Process	GO:0008284	positive regulation of cell population proliferation	Fgf18	IMP	MGI:MGI:2178751	Mouse	PMID:17014841
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	Fgf18	IGI	MGI:MGI:95524	Mouse	PMID:15781473
Biological Process	GO:2000546	positive regulation of endothelial cell chemotaxis to fibroblast growth factor	FGF18	IDA		Human	PMID:16756958
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Fgf18	IDA		Mouse	PMID:11741978
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	Fgf18	IDA		Rat	PMID:16756958|RGD:10047366
Biological Process	GO:0043406	positive regulation of MAP kinase activity	FGF18	IDA		Human	PMID:16756958
Biological Process	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	Fgf18	IMP	MGI:MGI:2178751	Mouse	PMID:17014841
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Fgf18	IMP	MGI:MGI:2178751	Mouse	PMID:17014841

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern