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Fgf18
Gene Detail
 Symbol
Name
ID
Fgf18
fibroblast growth factor 18
MGI:1277980
Synonyms D130055P09Rik, FGF-18
Feature Type protein coding gene
Genetic Map
Chromosome 11
19.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:33117430-33147400 bp, - strand
From VEGA annotation of GRCm38

  29971 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2867  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Fgf18

Human
homologs
Human Homolog FGF18, fibroblast growth factor 18
NCBI Gene ID 8817
neXtProt AC  NX_O76093
Human Synonyms  FGF-18, ZFGF5
Human Chr (Location)  5q34; chr5:171419663-171457626 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations die perinatally and exhibit impaired proliferation and differentiation of osteoblasts, shortened and thickened long bones, and delayed ossification of the calvarium and long bones.
 
Interactions
Fgf18 interacts with 78 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process angiogenesis, chondrocyte development, ...
Component extracellular region, nucleolus
Function fibroblast growth factor receptor binding, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (57 records)
Data Summary: Results (273)    Tissues (173)    Images (84)
Theiler Stages: 2, 4, 8, 9, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 222
RT-PCR 51
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(11) Primer pair(4) Other(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005390 (Evidence)
Ensembl Gene ModelENSMUSG00000057967 (Evidence)
Entrez Gene14172 (Evidence)
UniGene339812
DFCITC1587193
DoTSDT.55164803
NIA Mouse Gene IndexU032640
Consensus CDS ProjectCCDS24531.1
International Mouse Knockout Project StatusFgf18
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005390 VEGA Gene Model | MGI Sequence Detail 29971 C57BL/6J ±  kb
transcript OTTMUST00000012019 VEGA | MGI Sequence Detail 1086 Not Applicable 
polypeptide OTTMUSP00000005569 VEGA | MGI Sequence Detail 207 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(5) UniProt(2)
Polymorphisms SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007487 fibroblast growth factor 18
References (Earliest) J:48682 Ohbayashi N, et al., Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18. J Biol Chem. 1998 Jul 17;273(29):18161-4
(Latest) J:197686 Shang Y, et al., Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-beta-TAK1-dependent mechanism. PLoS Biol. 2013;11(4):e1001527
All references(97)
Other
accession IDs
MGI:2441946

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory