Fgf18
Gene Detail

Symbol Name ID

Fgf18 fibroblast growth factor 18 MGI:1277980

Synonyms

D130055P09Rik, FGF-18

Feature Type

protein coding gene

Genetic Map

Chromosome 11

19.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:33117430-33147400 bp, - strand From VEGA annotation of GRCm38   29971 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2867  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Fgf18

Human homologs

Human Homolog		FGF18, fibroblast growth factor 18
NCBI Gene ID		8817
neXtProt AC		NX_O76093
Human Synonyms		FGF-18, ZFGF5
Human Chr (Location)		5q34; chr5:170846667-170884630 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Homozygotes for targeted null mutations die perinatally and exhibit impaired proliferation and differentiation of osteoblasts, shortened and thickened long bones, and delayed ossification of the calvarium and long bones.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	angiogenesis, chondrocyte development, ...
Component	extracellular region, nucleolus
Function	fibroblast growth factor receptor binding, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (56 records)
Data Summary: Results (273)    Tissues (173)    Images (84)
Theiler Stages: 2, 4, 8, 9, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	222
RT-PCR	51

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(11) Primer pair(4) Other(5)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005390 (Evidence)
Ensembl Gene Model	ENSMUSG00000057967 (Evidence)
Entrez Gene	14172 (Evidence)
UniGene	339812
DFCI	TC1587193
DoTS	DT.55164803
NIA Mouse Gene Index	U032640
Consensus CDS Project	CCDS24531.1
International Mouse Knockout Project Status	Fgf18

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005390	VEGA Gene Model | MGI Sequence Detail	29971	C57BL/6J
transcript	OTTMUST00000012019	VEGA | MGI Sequence Detail	1086	Not Applicable
polypeptide	OTTMUSP00000005569	VEGA | MGI Sequence Detail	207	Not Applicable

All sequences(26) RefSeq(3) UniProt(3)

Polymorphisms

SNPs(21 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008996	Cytokine, IL-1-like
InterPro	IPR002348	Interleukin 1/heparin-binding growth factor
Protein Ontology	PR:000007487	fibroblast growth factor 18

References

(Earliest) J:48682 Ohbayashi N, et al., Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18. J Biol Chem. 1998 Jul 17;273(29):18161-4
(Latest) J:193313 Takase HM, et al., FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration. Genes Dev. 2013 Jan 15;27(2):169-81
All references(95)

Other accession IDs

MGI:2441946