Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FGF19
  • Mouse genes Fgf15
  • Rat genes Fgf19
  • Zfish genes fgf19
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fgf15

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005104	fibroblast growth factor receptor binding	FGF19	IPI	UniProtKB:P22455	Human	PMID:10525310
Molecular Function	GO:0005104	fibroblast growth factor receptor binding	FGF19	IPI	UniProtKB:P22455	Human	PMID:17627937
Molecular Function	GO:0005515	protein binding	FGF19	IPI	UniProtKB:Q86Z14	Human	PMID:18829467
Molecular Function	GO:0005515	protein binding	FGF19	IPI	UniProtKB:Q9UEF7	Human	PMID:18829467
Molecular Function	GO:0005515	protein binding	Fgf15	IPI	PR:A2AJX4	Mouse	PMID:23747249
Biological Process	GO:0015721	bile acid and bile salt transport	Fgf19	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:0007420	brain development	fgf19	IMP	ZFIN:ZDB-MRPHLNO-051220-8	Zfish	PMID:16256099
Biological Process	GO:0043010	camera-type eye development	fgf19	IMP	ZFIN:ZDB-MRPHLNO-051220-8	Zfish	PMID:17000708
Biological Process	GO:0043010	camera-type eye development	fgf19	IMP	ZFIN:ZDB-MRPHLNO-051220-8	Zfish	PMID:16256099
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGF19	IPI	UniProtKB:P22455	Human	PMID:10525310
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGF19	IGI	UniProtKB:P16092	Human	PMID:18187602
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGF19	IGI	UniProtKB:P21803	Human	PMID:18187602
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGF19	IGI	UniProtKB:Q03142	Human	PMID:18187602
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGF19	IGI	UniProtKB:Q61851	Human	PMID:18187602
Biological Process	GO:0007507	heart development	Fgf15	IMP	MGI:MGI:3044957	Mouse	PMID:15789410
Biological Process	GO:0002088	lens development in camera-type eye	fgf19	IMP	ZFIN:ZDB-MRPHLNO-051220-8	Zfish	PMID:18089288
Biological Process	GO:0002088	lens development in camera-type eye	fgf19	IMP	ZFIN:ZDB-MRPHLNO-080626-1	Zfish	PMID:18089288
Biological Process	GO:0070858	negative regulation of bile acid biosynthetic process	FGF19	IDA		Human	PMID:12815072
Biological Process	GO:0070858	negative regulation of bile acid biosynthetic process	Fgf15	IGI	MGI:MGI:1928271	Mouse	PMID:23747249
Biological Process	GO:0010629	negative regulation of gene expression	FGF19	IDA		Human	PMID:19085950
Biological Process	GO:0001755	neural crest cell migration	Fgf15	IMP	MGI:MGI:3044957	Mouse	PMID:15789410
Biological Process	GO:0048665	neuron fate specification	fgf19	IMP	ZFIN:ZDB-MRPHLNO-051220-8	Zfish	PMID:16256099
Biological Process	GO:0048709	oligodendrocyte differentiation	fgf19	IMP	ZFIN:ZDB-MRPHLNO-051220-8	Zfish	PMID:16256099
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGF19	IGI	UniProtKB:P16092	Human	PMID:18187602
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGF19	IGI	UniProtKB:P21803	Human	PMID:18187602
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGF19	IGI	UniProtKB:Q03142	Human	PMID:18187602
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGF19	IGI	UniProtKB:Q61851	Human	PMID:18187602
Biological Process	GO:0008284	positive regulation of cell population proliferation	fgf19	IMP	ZFIN:ZDB-MRPHLNO-051220-8	Zfish	PMID:16256099
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	FGF19	IDA		Human	PMID:17623664
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	FGF19	IDA		Human	PMID:19085950
Biological Process	GO:0046326	positive regulation of glucose import	FGF19	IDA		Human	PMID:17623664
Biological Process	GO:0046330	positive regulation of JNK cascade	FGF19	IDA		Human	PMID:12815072
Biological Process	GO:0050769	positive regulation of neurogenesis	fgf19	IMP	ZFIN:ZDB-MRPHLNO-051220-8	Zfish	PMID:16256099
Biological Process	GO:0001934	positive regulation of protein phosphorylation	FGF19	IDA		Human	PMID:17627937
Biological Process	GO:0009617	response to bacterium	Fgf15	IEP		Mouse	PMID:23012479
Biological Process	GO:0045471	response to ethanol	Fgf19	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:0014070	response to organic cyclic compound	Fgf19	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:0060041	retina development in camera-type eye	fgf19	IMP	ZFIN:ZDB-MRPHLNO-080626-1	Zfish	PMID:18089288
Biological Process	GO:0060041	retina development in camera-type eye	fgf19	IMP	ZFIN:ZDB-MRPHLNO-051220-8	Zfish	PMID:18089288
Biological Process	GO:0031290	retinal ganglion cell axon guidance	fgf19	IMP	ZFIN:ZDB-MRPHLNO-051220-8	Zfish	PMID:18089288

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern