Fgf15 MGI Mouse Gene Detail - MGI:1096383 - fibroblast growth factor 15

Symbol

Fgf15
Name

fibroblast growth factor 15
Synonyms

FGF19

Feature Type

protein coding gene
IDs

MGI:1096383
NCBI Gene: 14170
Alliance

genome feature page
Transcription Start Sites

7 TSS
Regulated by

Rr627, Rr629 (2 regulatory regions)

Sequence Map

Chr7:144450269-144454690 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 88.92 cM
Mapping Data

3 experiments

SNPs within 2kb

109 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1096383	protein coding gene	Chr7:144450268-144454690 (+)
129S1/SvImJ	ENSMUSG00200046041	protein coding gene	Chr7:131014766-131019195 (+)
A/J	ENSMUSG00195001739	protein coding gene	Chr7:135498395-135502832 (+)
AKR/J	ENSMUSG00220033075	protein coding gene	Chr7:128975499-128979957 (+)
BALB/cJ	ENSMUSG00180000889	protein coding gene	Chr7:132188334-132192790 (+)
C3H/HeJ	ENSMUSG00175003777	protein coding gene	Chr7:132919420-132923861 (+)
C57BL/6NJ	ENSMUSG00215000105	protein coding gene	Chr7:132185679-132190101 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030759	protein coding gene	Chr7:147073365-147077766 (+)
CAST/EiJ	ENSTCUG00005002834	protein coding gene	Chr7:135514351-135518827 (+)
CBA/J	ENSMUSG00210003548	protein coding gene	Chr7:132676915-132681352 (+)
DBA/2J	ENSMUSG00185014802	protein coding gene	Chr7:136955734-136960171 (+)
FVB/NJ	ENSMUSG00205001967	protein coding gene	Chr7:132583664-132588091 (+)
JF1/MsJ	ENSUMUG00000001902	protein coding gene	Chr7:141984101-141988527 (+)
LP/J	ENSMUSG00230007419	protein coding gene	Chr7:143117195-143121624 (+)
NOD/ShiLtJ	ENSMUSG00190003915	protein coding gene	Chr7:132784442-132788879 (+)
NZO/HlLtJ	ENSMUSG00225020982	protein coding gene	Chr7:141327776-141332213 (+)
PWK/PhJ	ENSLUMG00010037362	protein coding gene	Chr7:131153625-131158072 (+)
SPRET/EiJ	ENSMSPG00010001007	protein coding gene	Chr7:132719912-132724336 (+)
WSB/EiJ	ENSIUOG00005000902	protein coding gene	Chr7:133580148-133584572 (+)

Human Ortholog

FGF19, fibroblast growth factor 19

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FGF19, fibroblast growth factor 19
Links

HGNC:3675

NCBI Gene ID: 9965

UniProt: O95750
Chr Location

11q13.3; chr11:69698232-69704660 (-) GRCh38

MGI Vertebrate Homology

Fgf15 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FGF19
Protein SuperFamily

FGF-19_FGF-21
Gene Tree

Fgf15

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Phenotype Summary

21 phenotypes from 2 alleles in 3 genetic backgrounds
8 phenotypes from multigenic genotypes
1 images
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

4
Targeted

5
Incidental Mutations

APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Targeted inactivation of this gene leads to a severe underrepresentation of homozygotes at weaning as well as highly penetrant ventricular septal defects and malalignment of the aorta and pulmonary trunk. No abnormalities in otic induction or otic vesicle formation are observed.

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All GO Annotations

35
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1515
Tissues

493
cDNA Data

41
Literature Summary

125

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FGF19

Xenbase fgf19

ZFIN fgf19

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All Sequences

35
RefSeq

2
UniProt

2
CCDS

CCDS22053.1

Ensembl

ENSMUSG00000031073 (Evidence)
NCBI Gene

14170

			Length	Strain/Species	Flank
genomic	14170	NCBI Gene Model \| MGI Sequence Detail	4422	C57BL/6J	± kb
transcript	NM_008003	RefSeq \| MGI Sequence Detail	1809	C57BL/6
polypeptide	O35622	UniProt \| EBI \| MGI Sequence Detail	218	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007488 fibroblast growth factor 19

(term hierarchy)
InterPro Domains

IPR008996 Cytokine IL1/FGF

IPR035444 Fibroblast growth factor 15/19/21

IPR002209 Fibroblast growth factor family

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All nucleic 70

Genomic 2

cDNA 45

Primer pair 10

Other 13

Microarray probesets 3

Summaries

All 222

Developmental Gene Expression 125

Gene Ontology 9

Phenotypes 37
Earliest

J:43066 McWhirter JR, et al., A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. Development. 1997 Sep;124(17):3221-32
Latest

J:389099 Lin H, et al., The enterohepatic bile acid axis: from perinatal programming to metabolic collapse. Biochem Biophys Res Commun. 2026 Jul 9;830:154261

Fgf15 expression regulated by:

Feature	Feature Type	Location	Reference
Rr627, regulatory region 627	insulator	Chr7:144329467-144353354	J:361944
Rr629, regulatory region 629	enhancer	Chr7:144441251-144449797	J:361944

TSS for Fgf15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr70359	Chr7:144450201-144450208 (+)	-64 bp
Tssr70360	Chr7:144450260-144450276 (+)	-1 bp
Tssr70361	Chr7:144450754-144450774 (+)	495 bp
Tssr70362	Chr7:144450784-144450793 (+)	520 bp
Tssr70363	Chr7:144450798-144450808 (+)	534 bp
Tssr70364	Chr7:144450853-144450872 (+)	594 bp
Tssr70365	Chr7:144454168-144454211 (+)	3,921 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24