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Fgf15 Gene Detail
Summary
  • Symbol
    Fgf15
  • Name
    fibroblast growth factor 15
  • Synonyms
    FGF19
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096383
    NCBI Gene: 14170
  • Gene Overview
    MyGene.info: FGF19
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:144896532-144900953 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 88.92 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096383
protein coding gene Chr7:144896531-144900953 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033293
protein coding gene Chr7:150273135-150277563 (+)
A/J MGP_AJ_G0033276
protein coding gene Chr7:145921490-145925926 (+)
AKR/J MGP_AKRJ_G0033207
protein coding gene Chr7:150016499-150020953 (+)
BALB/cJ MGP_BALBcJ_G0033276
protein coding gene Chr7:145686231-145690745 (+)
C3H/HeJ MGP_C3HHeJ_G0032990
protein coding gene Chr7:149777808-149782248 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033786
protein coding gene Chr7:155692995-155697416 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030759
protein coding gene Chr7:147073365-147077766 (+)
CAST/EiJ MGP_CASTEiJ_G0032313
protein coding gene Chr7:142096186-142100665 (+)
CBA/J MGP_CBAJ_G0032963
protein coding gene Chr7:160990106-160994542 (+)
DBA/2J MGP_DBA2J_G0033117
protein coding gene Chr7:143883749-143888185 (+)
FVB/NJ MGP_FVBNJ_G0033065
protein coding gene Chr7:143827723-143832149 (+)
LP/J MGP_LPJ_G0033209
protein coding gene Chr7:151806656-151811084 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033099
protein coding gene Chr7:161518273-161522709 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033804
protein coding gene Chr7:148985137-148989573 (+)
PWK/PhJ MGP_PWKPhJ_G0032023
protein coding gene Chr7:137198823-137203269 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031867
protein coding gene Chr7:135773279-135777698 (+)
WSB/EiJ MGP_WSBEiJ_G0032426
protein coding gene Chr7:149973127-149977550 (+)



Homology
more
  • Human Ortholog
    FGF19, fibroblast growth factor 19
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FGF19, fibroblast growth factor 19
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 9965
    neXtProt AC: NX_O95750
    UniProt: O95750

  • Chr Location
    11q13.3; chr11:69698238-69704338 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    36 phenotypes from multigenic genotypes
    1 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted inactivation of this gene leads to a severe underrepresentation of homozygotes at weaning as well as highly penetrant ventricular septal defects and malalignment of the aorta and pulmonary trunk. No abnormalities in otic induction or otic vesicle formation are observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14170 NCBI Gene Model | MGI Sequence Detail 4422 C57BL/6J ±  kb
    transcript NM_008003 RefSeq | MGI Sequence Detail 1809 C57BL/6  
    polypeptide O35622 UniProt | EBI | MGI Sequence Detail 218 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 2
      cDNA 44
      Primer pair 7
      Other 7

      Microarray probesets 3
    References
    more
    • Summaries
      All 154
      Developmental Gene Expression 92
      Diseases 2
      Gene Ontology 7
      Phenotypes 25
    • Earliest
      J:43066 McWhirter JR, et al., A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. Development. 1997 Sep;124(17):3221-32
    • Latest
      J:252112 Kim JJ, et al., Suppressor of fused controls cerebellar neuronal differentiation in a manner modulated by GLI3 repressor and Fgf15. Dev Dyn. 2018 Jan;247(1):156-169

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory