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Fgf15
Gene Detail
 Symbol
Name
ID
Fgf15
fibroblast growth factor 15
MGI:1096383
Synonyms FGF19
Feature Type protein coding gene
Genetic Map
Chromosome 7
88.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:144896532-144900953 bp, + strand
From NCBI annotation of GRCm38

  4422 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3754  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: fibroblast growth factor, 15/19/21 types
Gene Tree: Fgf15

Human
homologs
Human Homolog FGF19, fibroblast growth factor 19
NCBI Gene ID 9965
neXtProt AC  NX_O95750
Human Chr (Location)  11q13.1; chr11:69698238-69704338 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Targeted inactivation of this gene leads to a severe underrepresentation of homozygotes at weaning as well as highly penetrant ventricular septal defects and malalignment of the aorta and pulmonary trunk. No abnormalities in otic induction or otic vesicle formation are observed.
 
Phenotype Images(1)
Interactions
Fgf15 interacts with 190 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process fibroblast growth factor receptor signaling pathway, heart development, ...
Component extracellular region
Function fibroblast growth factor receptor binding, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (73 records)
Data Summary: Results (574)    Tissues (332)    Images (147)
Theiler Stages: 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 562
Northern blot 4
RT-PCR 8
cDNA source data(38)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(52) Genomic(2) cDNA(41) Primer pair(4) Other(5)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031073 (Evidence)
Entrez Gene14170 (Evidence)
UniGene3904
DFCITC1578560
DoTSDT.99858121
NIA Mouse Gene IndexU029529
Consensus CDS ProjectCCDS22053.1
International Mouse Knockout Project StatusFgf15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14170 NCBI Gene Model | MGI Sequence Detail 4422 C57BL/6J ±  kb
transcript NM_008003 RefSeq | MGI Sequence Detail 1809 C57BL/6 
polypeptide O35622 UniProt | EBI | MGI Sequence Detail 218 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007488 fibroblast growth factor 19
Graphical View of Protein Domain Structure
References (Earliest) J:43066 McWhirter JR, et al., A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. Development. 1997 Sep;124(17):3221-32
(Latest) J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All references(112)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory