Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FCGR2A
  • Mouse genes Fcgr3
  • Rat genes Fcgr2a,LOC498276
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fcgr3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019864	IgG binding	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:9834201
Molecular Function	GO:0019864	IgG binding	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:9743367
Molecular Function	GO:0019770	IgG receptor activity	Fcgr3	IDA		Mouse	MGI:MGI:3718147|PMID:17558411
Molecular Function	GO:0019770	IgG receptor activity	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:9834201
Molecular Function	GO:0019770	IgG receptor activity	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:9743367
Molecular Function	GO:0034987	immunoglobulin receptor binding	Fcgr2a	IDA		Rat	PMID:22184119|RGD:11041001
Molecular Function	GO:0005515	protein binding	FCGR2A	IPI	UniProtKB:Q9UMX0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FCGR2A	IPI	UniProtKB:Q9UMX0-2	Human	PMID:25416956
Cellular Component	GO:0009986	cell surface	Fcgr3	IDA		Mouse	MGI:MGI:3718147|PMID:17558411
Cellular Component	GO:0009986	cell surface	Fcgr2a	IDA		Rat	PMID:22184119|RGD:11041001
Cellular Component	GO:0009897	external side of plasma membrane	Fcgr3	IDA		Mouse	PMID:19360001
Cellular Component	GO:0005794	Golgi apparatus	FCGR2A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	FCGR2A	IDA		Human	GO_REF:0000052
Biological Process	GO:0001788	antibody-dependent cellular cytotoxicity	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:9743367
Biological Process	GO:0001788	antibody-dependent cellular cytotoxicity	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:8769481
Biological Process	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:11911824
Biological Process	GO:0007166	cell surface receptor signaling pathway	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:8769481
Biological Process	GO:0045576	mast cell activation	Fcgr3	IDA		Mouse	PMID:8552190
Biological Process	GO:0045576	mast cell activation	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:8769481
Biological Process	GO:0021675	nerve development	Fcgr2a	IEP		Rat	PMID:1533683|RGD:2316290
Biological Process	GO:0030593	neutrophil chemotaxis	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:11420040
Biological Process	GO:0006911	phagocytosis, engulfment	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:9834201
Biological Process	GO:0006911	phagocytosis, engulfment	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:8769481
Biological Process	GO:0006911	phagocytosis, engulfment	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:9743367
Biological Process	GO:0006910	phagocytosis, recognition	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:8769481
Biological Process	GO:0006910	phagocytosis, recognition	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:9743367
Biological Process	GO:0006910	phagocytosis, recognition	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:9834201
Biological Process	GO:0050766	positive regulation of phagocytosis	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:9743367
Biological Process	GO:0050766	positive regulation of phagocytosis	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:9834201
Biological Process	GO:0050766	positive regulation of phagocytosis	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:8769481
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:10229794
Biological Process	GO:0001812	positive regulation of type I hypersensitivity	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:9743367
Biological Process	GO:0001812	positive regulation of type I hypersensitivity	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:8769481
Biological Process	GO:0001812	positive regulation of type I hypersensitivity	Fcgr3	IDA		Mouse	PMID:8552190
Biological Process	GO:0001798	positive regulation of type IIa hypersensitivity	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:9834201
Biological Process	GO:0001798	positive regulation of type IIa hypersensitivity	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:11911824
Biological Process	GO:0001805	positive regulation of type III hypersensitivity	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:8769481
Biological Process	GO:0001813	regulation of antibody-dependent cellular cytotoxicity	Fcgr2a	IMP		Rat	PMID:16482158|RGD:2293335
Biological Process	GO:1905449	regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	Fcgr2a	IMP		Rat	PMID:16482158|RGD:2293335
Biological Process	GO:1905449	regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	Fcgr2a	IMP		Rat	PMID:22184119|RGD:11041001
Biological Process	GO:0050776	regulation of immune response	Fcgr3	IMP	MGI:MGI:1861924	Mouse	PMID:11911824
Biological Process	GO:0032680	regulation of tumor necrosis factor production	Fcgr2a	IMP		Rat	PMID:22184119|RGD:11041001
Biological Process	GO:0001820	serotonin secretion	Fcgr3	IDA		Mouse	PMID:8552190

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern