About   Help   FAQ
Fcgr3
Gene Detail
Symbol

Name
ID
Fcgr3
Fc receptor, IgG, low affinity III
MGI:95500
Synonyms
CD16, FcgammaRIII, Fcg receptor III
Feature Type
protein coding gene
Genetic Map
Chromosome 1
78.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr1:171051174-171064935 bp, - strand
From VEGA annotation of GRCm38

  13762 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47936  Vertebrate Homology Class
1 human; 1 mouse; 5 rat; 1 chimpanzee; 1 rhesus macaque

HCOP human homology predictions: FCGR2A
Protein SuperFamily: Fc gamma receptor III
Gene Tree: Fcgr3

Human
homologs
FCGR2A, Fc fragment of IgG, low affinity IIa, receptor (CD32)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2212
neXtProt AC: NX_P12318

Human Synonyms: CD32, CD32A, CDw32, FCG2, FcGR, FCGR2, FCGR2A1, IGFR2

Human Chr (Location): 1q23; chr1:161505415-161524048 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FCGR2A

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Not Specified(1) Targeted(6) Transgenic(1)
Genomic Mutations involving Fcgr3 (2)
 
Homozygotes for a targeted null mutation lack IgG-mediated mast cell degranulation and have impaired IgG-dependent anaphylaxis and Arthus reactions.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Fcgr3 interacts with 98 markers (Mir31, Mir129-1, Mir129-2, ...)
Expression
Literature Summary: (4 records)
Data Summary: Results (3)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 3
cDNA source data(76)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(84) Genomic(7) cDNA(76) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000035155 (Evidence)
Ensembl Gene Model ENSMUSG00000059498 (Evidence)
Entrez Gene 14131 (Evidence)
UniGene 22119
DFCI TC1574337, TC1581981
DoTS DT.101405407, DT.110931607, DT.87072902, DT.99868463
NIA Mouse Gene Index U022043
Consensus CDS Project CCDS15477.2
International Mouse Phenotyping Consortium Status Fcgr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035155 VEGA Gene Model | MGI Sequence Detail 13762 C57BL/6J ±  kb
transcript OTTMUST00000089518 VEGA | MGI Sequence Detail 1347 Not Applicable 
polypeptide OTTMUSP00000048932 VEGA | MGI Sequence Detail 267 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(10) UniProt(8)
Polymorphisms
RFLP(5) : SNPs within 2kb(247 from dbSNP Build 137)    SNPs within 2kb including multiple locations(251)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000001483 low affinity immunoglobulin gamma Fc region receptor III
References
(Earliest) J:8467 Ravetch JV, et al., Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors. Science. 1986 Nov 7;234(4777):718-25
(Latest) J:221858 Negishi-Koga T, et al., Immune complexes regulate bone metabolism through FcRgamma signalling. Nat Commun. 2015;6:6637
All references(182)
Other
accession IDs
MGD-MRK-9736

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory