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Fcgr3 Gene Detail
Summary
  • Symbol
    Fcgr3
  • Name
    Fc receptor, IgG, low affinity III
  • Synonyms
    CD16, FcgammaRIII, Fcg receptor III
  • Feature Type
    protein coding gene
  • IDs
    MGI:95500
    NCBI Gene: 14131
  • Gene Overview
    MyGene.info: FCGR2A
Location & Maps
more
  • Sequence Map
    Chr1:171051174-171064935 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13762 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 78.80 cM
  • Mapping Data
    30 experiments
Homology
more
  • Human Ortholog
    FCGR2A, Fc fragment of IgG receptor IIa
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FCGR2A, Fc fragment of IgG receptor IIa
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD32, CD32A, CDw32, FCG2, FcGR, FCGR2, FCGR2A1, IGFR2
  • Links
    NCBI Gene ID: 2212
    neXtProt AC: NX_P12318

  • Chr Location
    1q23.3; chr1:161505415-161524048 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human FCGR2A associations

Human Disease Mouse Models
       Malaria, Susceptibility to   OMIM: 611162
Systemic Lupus Erythematosus; SLE   OMIM: 152700
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    29 phenotypes from multigenic genotypes
    133 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Not Specified
    1
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    4 involving Fcgr3
Homozygotes for a targeted null mutation lack IgG-mediated mast cell degranulation and have impaired IgG-dependent anaphylaxis and Arthus reactions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035155 VEGA Gene Model | MGI Sequence Detail 13762 C57BL/6J ±  kb
transcript OTTMUST00000089518 VEGA | MGI Sequence Detail 1347 Not Applicable  
polypeptide OTTMUSP00000048932 VEGA | MGI Sequence Detail 267 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    229 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 84
    Genomic 7
    cDNA 76
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-9736
References
more
  • Summaries
    All 187
    Developmental Gene Expression 4
    Diseases 2
    Gene Ontology 10
    Phenotypes 133
  • Earliest
    J:8467 Ravetch JV, et al., Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors. Science. 1986 Nov 7;234(4777):718-25
  • Latest
    J:234977 Young A, et al., Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses. Cancer Cell. 2016 Sep 12;30(3):391-403

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory