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Fcgr3
Gene Detail
 Symbol
Name
ID
Fcgr3
Fc receptor, IgG, low affinity III
MGI:95500
Synonyms CD16, FcgammaRIII, Fcg receptor III
Feature Type protein coding gene
Genetic Map
Chromosome 1
78.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr1:171051174-171064935 bp, - strand
From VEGA annotation of GRCm38

  13762 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47936  Vertebrate Homology Class
1 human; 1 mouse; 5 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: Fc gamma receptor III
Gene Tree: Fcgr3

Human
homologs
Human Homolog FCGR2A, Fc fragment of IgG, low affinity IIa, receptor (CD32)
NCBI Gene ID 2212
neXtProt AC  NX_P12318
Human Synonyms  CD32, CD32A, CDw32, FCG2, FcGR, FCGR2, FCGR2A1, IGFR2
Human Chr (Location)  1q23; chr1:161505415-161519570 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FCGR2A
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Not Specified(1) Targeted(6)
Genomic Mutations involving Fcgr3 (2)
 
Homozygotes for a targeted null mutation lack IgG-mediated mast cell degranulation and have impaired IgG-dependent anaphylaxis and Arthus reactions.
 
Interactions
Fcgr3 interacts with 98 markers (Mir31, Mir129-1, Mir129-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process antibody-dependent cellular cytotoxicity, antigen processing and presentation of exogenous peptide antigen via MHC class I, ...
Component cell, extracellular vesicular exosome, ...
Function IgG binding, IgG receptor activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (3)    Tissues (3)   
Theiler Stages: 20, 22, 28
Assay TypeResults
RT-PCR 3
cDNA source data(76)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(84) Genomic(7) cDNA(76) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000035155 (Evidence)
Ensembl Gene ModelENSMUSG00000059498 (Evidence)
Entrez Gene14131 (Evidence)
UniGene22119
DFCITC1574337, TC1581981
DoTSDT.101405407, DT.110931607, DT.87072902, DT.99868463
NIA Mouse Gene IndexU022043
Consensus CDS ProjectCCDS15477.2
International Mouse Knockout Project StatusFcgr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035155 VEGA Gene Model | MGI Sequence Detail 13762 C57BL/6J ±  kb
transcript OTTMUST00000089518 VEGA | MGI Sequence Detail 1347 Not Applicable 
polypeptide OTTMUSP00000048932 VEGA | MGI Sequence Detail 267 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(10) UniProt(7)
Polymorphisms RFLP(5) : SNPs within 2kb(247 from dbSNP Build 137)    SNPs within 2kb including multiple locations(251)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000001483 low affinity immunoglobulin gamma Fc region receptor III
References (Earliest) J:8467 Ravetch JV, et al., Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors. Science. 1986 Nov 7;234(4777):718-25
(Latest) J:206868 DiLillo DJ, et al., Broadly neutralizing hemagglutinin stalk-specific antibodies require FcgammaR interactions for protection against influenza virus in vivo. Nat Med. 2014 Feb;20(2):143-51
All references(174)
Other
accession IDs
MGD-MRK-9736

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory