About   Help   FAQ
Due to maintenance, access to MGI maybe intermittent on Thu, May 23 at 7:30 AM ET.
Fcgr3 Gene Detail
Summary
  • Symbol
    Fcgr3
  • Name
    Fc receptor, IgG, low affinity III
  • Synonyms
    CD16, FcgammaRIII, Fcg receptor III
  • Feature Type
    protein coding gene
  • IDs
    MGI:95500
    NCBI Gene: 14131
  • Gene Overview
    MyGene.info: FCGR2A
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:171051174-171064935 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 78.80 cM
  • Mapping Data
    30 experiments
Strain
Comparison
more
  • SNPs within 2kb
    229 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95500
protein coding gene Chr1:171051169-171065936 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016740
protein coding gene Chr1:176807636-176826797 (-)
A/J MGP_AJ_G0016720
protein coding gene Chr1:169592956-169602534 (-)
AKR/J MGP_AKRJ_G0016686
protein coding gene Chr1:174688209-174714160 (-)
BALB/cJ MGP_BALBcJ_G0016681
protein coding gene Chr1:170070327-170078884 (-)
C3H/HeJ MGP_C3HHeJ_G0016504
protein coding gene Chr1:174939450-174950753 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017142
protein coding gene Chr1:182662753-182707677 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0016085
protein coding gene Chr1:174566464-174575943 (-)
CBA/J MGP_CBAJ_G0016479
protein coding gene Chr1:189165044-189221367 (-)
DBA/2J MGP_DBA2J_G0016586
protein coding gene Chr1:168447204-168474777 (-)
FVB/NJ MGP_FVBNJ_G0016582
protein coding gene Chr1:166806140-166843879 (-)
LP/J MGP_LPJ_G0016657
protein coding gene Chr1:177927179-177945764 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016609
protein coding gene Chr1:196449022-196521956 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017179
protein coding gene Chr1:174571740-174599531 (-)
PWK/PhJ MGP_PWKPhJ_G0015871
protein coding gene Chr1:167685595-167705976 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015655
protein coding gene Chr1:173327971-173344547 (-)
WSB/EiJ MGP_WSBEiJ_G0016147
protein coding gene Chr1:174694476-174704188 (-)



Homology
more
  • Human Ortholog
    FCGR2A, Fc fragment of IgG receptor IIa
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FCGR2A, Fc fragment of IgG receptor IIa
    Orthology source: HomoloGene
  • Synonyms
    CD32, CD32A, CDw32, FCG2, FcGR, FCGR2, FCGR2A1, IGFR2
  • Links
    NCBI Gene ID: 2212
    neXtProt AC: NX_P12318
    UniProt: P12318

  • Chr Location
    1q23.3; chr1:161505415-161524048 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with human FCGR2A associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 4 genetic backgrounds
    30 phenotypes from multigenic genotypes
    153 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation lack IgG-mediated mast cell degranulation and have impaired IgG-dependent anaphylaxis and Arthus reactions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059498 Ensembl Gene Model | MGI Sequence Detail 13762 C57BL/6J ±  kb
    transcript ENSMUST00000164044 Ensembl | MGI Sequence Detail 1347 Not Applicable  
    polypeptide ENSMUSP00000131938 Ensembl | MGI Sequence Detail 267 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 86
      Genomic 7
      cDNA 77
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-9736
    References
    more
    • Summaries
      All 244
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 11
      Phenotypes 153
    • Earliest
      J:8467 Ravetch JV, et al., Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors. Science. 1986 Nov 7;234(4777):718-25
    • Latest
      J:264675 Fransen MF, et al., A Restricted Role for FcgammaR in the Regulation of Adaptive Immunity. J Immunol. 2018 Apr 15;200(8):2615-2626

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/07/2019
    MGI 6.14
    The Jackson Laboratory