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Gene Ontology Browser
Term Detail
GO term:regulation of tumor necrosis factor production
Synonym: regulation of TNF-alpha production
Synonym: regulation of TNF production
Synonym: regulation of tumor necrosis factor-alpha production
GO id:GO:0032680
Definition:Any process that modulates the frequency, rate, or extent of tumor necrosis factor production.
CommentsNote that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
Number of paths to term: 6

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of multicellular organismal process
                                        is-aregulation of cytokine production
                                                is-amodulation by virus of host cytokine production +
                                                is-anegative regulation of cytokine production +
                                                is-apositive regulation of cytokine production +
                                                is-aregulation of chemokine production +
                                                is-aregulation of connective tissue growth factor production +
                                                is-aregulation of cytokine biosynthetic process +
                                                is-aregulation of cytokine production involved in immune response +
                                                is-aregulation of cytokine production involved in inflammatory response +
                                                is-aregulation of cytokine secretion +
                                                is-aregulation of fibroblast growth factor production +
                                                is-aregulation of granulocyte macrophage colony-stimulating factor production +
                                                is-aregulation of granzyme B production +
                                                is-aregulation of hepatocyte growth factor production +
                                                is-aregulation of interferon-gamma production +
                                                is-aregulation of interleukin-1 production +
                                                is-aregulation of interleukin-10 production +
                                                is-aregulation of interleukin-11 production +
                                                is-aregulation of interleukin-12 production +
                                                is-aregulation of interleukin-13 production +
                                                is-aregulation of interleukin-14 production +
                                                is-aregulation of interleukin-15 production +
                                                is-aregulation of interleukin-16 production +
                                                is-aregulation of interleukin-17 production +
                                                is-aregulation of interleukin-18 production +
                                                is-aregulation of interleukin-19 production +
                                                is-aregulation of interleukin-2 production +
                                                is-aregulation of interleukin-20 production +
                                                is-aregulation of interleukin-21 production +
                                                is-aregulation of interleukin-22 production +
                                                is-aregulation of interleukin-23 production +
                                                is-aregulation of interleukin-24 production +
                                                is-aregulation of interleukin-25 production +
                                                is-aregulation of interleukin-26 production +
                                                is-aregulation of interleukin-27 production +
                                                is-aregulation of interleukin-3 production +
                                                is-aregulation of interleukin-35 production +
                                                is-aregulation of interleukin-4 production +
                                                is-aregulation of interleukin-5 production +
                                                is-aregulation of interleukin-6 production +
                                                is-aregulation of interleukin-7 production +
                                                is-aregulation of interleukin-8 production +
                                                is-aregulation of interleukin-9 production +
                                                is-aregulation of lymphotoxin A production +
                                                is-aregulation of macrophage colony-stimulating factor production +
                                                is-aregulation of platelet-derived growth factor production +
                                                is-aregulation of TRAIL production +
                                                is-aregulation of transforming growth factor beta production +
                                                is-aregulation of tumor necrosis factor (ligand) superfamily member 11 production +
                                                is-aregulation of tumor necrosis factor production [GO:0032680] (86 genes, 116 annotations)
                                                        is-anegative regulation of tumor necrosis factor production
                                                        is-apositive regulation of tumor necrosis factor production
                                                        is-aregulation of tumor necrosis factor biosynthetic process +
                                                is-aregulation of type I interferon production +
                                                is-aregulation of type III interferon production +
                                                is-aregulation of vascular endothelial growth factor production +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        regulatesregulation of cytokine production
                                                is-amodulation by virus of host cytokine production +
                                                is-anegative regulation of cytokine production +
                                                is-apositive regulation of cytokine production +
                                                is-aregulation of chemokine production +
                                                is-aregulation of connective tissue growth factor production +
                                                is-aregulation of cytokine biosynthetic process +
                                                is-aregulation of cytokine production involved in immune response +
                                                is-aregulation of cytokine production involved in inflammatory response +
                                                is-aregulation of cytokine secretion +
                                                is-aregulation of fibroblast growth factor production +
                                                is-aregulation of granulocyte macrophage colony-stimulating factor production +
                                                is-aregulation of granzyme B production +
                                                is-aregulation of hepatocyte growth factor production +
                                                is-aregulation of interferon-gamma production +
                                                is-aregulation of interleukin-1 production +
                                                is-aregulation of interleukin-10 production +
                                                is-aregulation of interleukin-11 production +
                                                is-aregulation of interleukin-12 production +
                                                is-aregulation of interleukin-13 production +
                                                is-aregulation of interleukin-14 production +
                                                is-aregulation of interleukin-15 production +
                                                is-aregulation of interleukin-16 production +
                                                is-aregulation of interleukin-17 production +
                                                is-aregulation of interleukin-18 production +
                                                is-aregulation of interleukin-19 production +
                                                is-aregulation of interleukin-2 production +
                                                is-aregulation of interleukin-20 production +
                                                is-aregulation of interleukin-21 production +
                                                is-aregulation of interleukin-22 production +
                                                is-aregulation of interleukin-23 production +
                                                is-aregulation of interleukin-24 production +
                                                is-aregulation of interleukin-25 production +
                                                is-aregulation of interleukin-26 production +
                                                is-aregulation of interleukin-27 production +
                                                is-aregulation of interleukin-3 production +
                                                is-aregulation of interleukin-35 production +
                                                is-aregulation of interleukin-4 production +
                                                is-aregulation of interleukin-5 production +
                                                is-aregulation of interleukin-6 production +
                                                is-aregulation of interleukin-7 production +
                                                is-aregulation of interleukin-8 production +
                                                is-aregulation of interleukin-9 production +
                                                is-aregulation of lymphotoxin A production +
                                                is-aregulation of macrophage colony-stimulating factor production +
                                                is-aregulation of platelet-derived growth factor production +
                                                is-aregulation of TRAIL production +
                                                is-aregulation of transforming growth factor beta production +
                                                is-aregulation of tumor necrosis factor (ligand) superfamily member 11 production +
                                                is-aregulation of tumor necrosis factor production [GO:0032680] (86 genes, 116 annotations)
                                                        is-anegative regulation of tumor necrosis factor production
                                                        is-apositive regulation of tumor necrosis factor production
                                                        is-aregulation of tumor necrosis factor biosynthetic process +
                                                is-aregulation of type I interferon production +
                                                is-aregulation of type III interferon production +
                                                is-aregulation of vascular endothelial growth factor production +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        is-atumor necrosis factor superfamily cytokine production
                                                is-atumor necrosis factor production
                                                        negatively-regulatesnegative regulation of tumor necrosis factor production
                                                        positively-regulatespositive regulation of tumor necrosis factor production
                                                        regulatesregulation of tumor necrosis factor production [GO:0032680] (86 genes, 116 annotations)
                                                                is-anegative regulation of tumor necrosis factor production
                                                                is-apositive regulation of tumor necrosis factor production
                                                                is-aregulation of tumor necrosis factor biosynthetic process +
                                                        part-oftumor necrosis factor biosynthetic process +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of multicellular organismal process
                                is-aregulation of cytokine production
                                        is-amodulation by virus of host cytokine production +
                                        is-anegative regulation of cytokine production +
                                        is-apositive regulation of cytokine production +
                                        is-aregulation of chemokine production +
                                        is-aregulation of connective tissue growth factor production +
                                        is-aregulation of cytokine biosynthetic process +
                                        is-aregulation of cytokine production involved in immune response +
                                        is-aregulation of cytokine production involved in inflammatory response +
                                        is-aregulation of cytokine secretion +
                                        is-aregulation of fibroblast growth factor production +
                                        is-aregulation of granulocyte macrophage colony-stimulating factor production +
                                        is-aregulation of granzyme B production +
                                        is-aregulation of hepatocyte growth factor production +
                                        is-aregulation of interferon-gamma production +
                                        is-aregulation of interleukin-1 production +
                                        is-aregulation of interleukin-10 production +
                                        is-aregulation of interleukin-11 production +
                                        is-aregulation of interleukin-12 production +
                                        is-aregulation of interleukin-13 production +
                                        is-aregulation of interleukin-14 production +
                                        is-aregulation of interleukin-15 production +
                                        is-aregulation of interleukin-16 production +
                                        is-aregulation of interleukin-17 production +
                                        is-aregulation of interleukin-18 production +
                                        is-aregulation of interleukin-19 production +
                                        is-aregulation of interleukin-2 production +
                                        is-aregulation of interleukin-20 production +
                                        is-aregulation of interleukin-21 production +
                                        is-aregulation of interleukin-22 production +
                                        is-aregulation of interleukin-23 production +
                                        is-aregulation of interleukin-24 production +
                                        is-aregulation of interleukin-25 production +
                                        is-aregulation of interleukin-26 production +
                                        is-aregulation of interleukin-27 production +
                                        is-aregulation of interleukin-3 production +
                                        is-aregulation of interleukin-35 production +
                                        is-aregulation of interleukin-4 production +
                                        is-aregulation of interleukin-5 production +
                                        is-aregulation of interleukin-6 production +
                                        is-aregulation of interleukin-7 production +
                                        is-aregulation of interleukin-8 production +
                                        is-aregulation of interleukin-9 production +
                                        is-aregulation of lymphotoxin A production +
                                        is-aregulation of macrophage colony-stimulating factor production +
                                        is-aregulation of platelet-derived growth factor production +
                                        is-aregulation of TRAIL production +
                                        is-aregulation of transforming growth factor beta production +
                                        is-aregulation of tumor necrosis factor (ligand) superfamily member 11 production +
                                        is-aregulation of tumor necrosis factor production [GO:0032680] (86 genes, 116 annotations)
                                                is-anegative regulation of tumor necrosis factor production
                                                is-apositive regulation of tumor necrosis factor production
                                                is-aregulation of tumor necrosis factor biosynthetic process +
                                        is-aregulation of type I interferon production +
                                        is-aregulation of type III interferon production +
                                        is-aregulation of vascular endothelial growth factor production +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        regulatesregulation of cytokine production
                                                is-amodulation by virus of host cytokine production +
                                                is-anegative regulation of cytokine production +
                                                is-apositive regulation of cytokine production +
                                                is-aregulation of chemokine production +
                                                is-aregulation of connective tissue growth factor production +
                                                is-aregulation of cytokine biosynthetic process +
                                                is-aregulation of cytokine production involved in immune response +
                                                is-aregulation of cytokine production involved in inflammatory response +
                                                is-aregulation of cytokine secretion +
                                                is-aregulation of fibroblast growth factor production +
                                                is-aregulation of granulocyte macrophage colony-stimulating factor production +
                                                is-aregulation of granzyme B production +
                                                is-aregulation of hepatocyte growth factor production +
                                                is-aregulation of interferon-gamma production +
                                                is-aregulation of interleukin-1 production +
                                                is-aregulation of interleukin-10 production +
                                                is-aregulation of interleukin-11 production +
                                                is-aregulation of interleukin-12 production +
                                                is-aregulation of interleukin-13 production +
                                                is-aregulation of interleukin-14 production +
                                                is-aregulation of interleukin-15 production +
                                                is-aregulation of interleukin-16 production +
                                                is-aregulation of interleukin-17 production +
                                                is-aregulation of interleukin-18 production +
                                                is-aregulation of interleukin-19 production +
                                                is-aregulation of interleukin-2 production +
                                                is-aregulation of interleukin-20 production +
                                                is-aregulation of interleukin-21 production +
                                                is-aregulation of interleukin-22 production +
                                                is-aregulation of interleukin-23 production +
                                                is-aregulation of interleukin-24 production +
                                                is-aregulation of interleukin-25 production +
                                                is-aregulation of interleukin-26 production +
                                                is-aregulation of interleukin-27 production +
                                                is-aregulation of interleukin-3 production +
                                                is-aregulation of interleukin-35 production +
                                                is-aregulation of interleukin-4 production +
                                                is-aregulation of interleukin-5 production +
                                                is-aregulation of interleukin-6 production +
                                                is-aregulation of interleukin-7 production +
                                                is-aregulation of interleukin-8 production +
                                                is-aregulation of interleukin-9 production +
                                                is-aregulation of lymphotoxin A production +
                                                is-aregulation of macrophage colony-stimulating factor production +
                                                is-aregulation of platelet-derived growth factor production +
                                                is-aregulation of TRAIL production +
                                                is-aregulation of transforming growth factor beta production +
                                                is-aregulation of tumor necrosis factor (ligand) superfamily member 11 production +
                                                is-aregulation of tumor necrosis factor production [GO:0032680] (86 genes, 116 annotations)
                                                        is-anegative regulation of tumor necrosis factor production
                                                        is-apositive regulation of tumor necrosis factor production
                                                        is-aregulation of tumor necrosis factor biosynthetic process +
                                                is-aregulation of type I interferon production +
                                                is-aregulation of type III interferon production +
                                                is-aregulation of vascular endothelial growth factor production +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        is-atumor necrosis factor superfamily cytokine production
                                                is-atumor necrosis factor production
                                                        negatively-regulatesnegative regulation of tumor necrosis factor production
                                                        positively-regulatespositive regulation of tumor necrosis factor production
                                                        regulatesregulation of tumor necrosis factor production [GO:0032680] (86 genes, 116 annotations)
                                                                is-anegative regulation of tumor necrosis factor production
                                                                is-apositive regulation of tumor necrosis factor production
                                                                is-aregulation of tumor necrosis factor biosynthetic process +
                                                        part-oftumor necrosis factor biosynthetic process +


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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory