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Gene Ontology Browser
Term Detail
GO term:regulation of tumor necrosis factor production
Synonym: regulation of TNF-alpha production
Synonym: regulation of TNF production
Synonym: regulation of tumor necrosis factor-alpha production
GO id:GO:0032680
Definition:Any process that modulates the frequency, rate, or extent of tumor necrosis factor production.
CommentsNote that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
Number of paths to term: 8

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of multicellular organismal process
                                        is-aregulation of cytokine production
                                                is-aregulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of tumor necrosis factor superfamily cytokine production +
                                                        is-apositive regulation of tumor necrosis factor superfamily cytokine production +
                                                        is-aregulation of lymphotoxin A production +
                                                        is-aregulation of TRAIL production +
                                                        is-aregulation of tumor necrosis factor (ligand) superfamily member 11 production +
                                                        is-aregulation of tumor necrosis factor production [GO:0032680] (91 genes, 121 annotations)
                                                                is-anegative regulation of tumor necrosis factor production +
                                                                is-apositive regulation of tumor necrosis factor production +
                                                                is-aregulation of tumor necrosis factor biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        regulatesregulation of cytokine production
                                                is-aregulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of tumor necrosis factor superfamily cytokine production +
                                                        is-apositive regulation of tumor necrosis factor superfamily cytokine production +
                                                        is-aregulation of lymphotoxin A production +
                                                        is-aregulation of TRAIL production +
                                                        is-aregulation of tumor necrosis factor (ligand) superfamily member 11 production +
                                                        is-aregulation of tumor necrosis factor production [GO:0032680] (91 genes, 121 annotations)
                                                                is-anegative regulation of tumor necrosis factor production +
                                                                is-apositive regulation of tumor necrosis factor production +
                                                                is-aregulation of tumor necrosis factor biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        is-atumor necrosis factor superfamily cytokine production
                                                regulatesregulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of tumor necrosis factor superfamily cytokine production +
                                                        is-apositive regulation of tumor necrosis factor superfamily cytokine production +
                                                        is-aregulation of lymphotoxin A production +
                                                        is-aregulation of TRAIL production +
                                                        is-aregulation of tumor necrosis factor (ligand) superfamily member 11 production +
                                                        is-aregulation of tumor necrosis factor production [GO:0032680] (91 genes, 121 annotations)
                                                                is-anegative regulation of tumor necrosis factor production +
                                                                is-apositive regulation of tumor necrosis factor production +
                                                                is-aregulation of tumor necrosis factor biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        is-atumor necrosis factor superfamily cytokine production
                                                is-atumor necrosis factor production
                                                        negatively-regulatesnegative regulation of tumor necrosis factor production +
                                                        positively-regulatespositive regulation of tumor necrosis factor production +
                                                        regulatesregulation of tumor necrosis factor production [GO:0032680] (91 genes, 121 annotations)
                                                                is-anegative regulation of tumor necrosis factor production +
                                                                is-apositive regulation of tumor necrosis factor production +
                                                                is-aregulation of tumor necrosis factor biosynthetic process +
                                                        part-oftumor necrosis factor biosynthetic process +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of multicellular organismal process
                                is-aregulation of cytokine production
                                        is-aregulation of tumor necrosis factor superfamily cytokine production
                                                is-anegative regulation of tumor necrosis factor superfamily cytokine production +
                                                is-apositive regulation of tumor necrosis factor superfamily cytokine production +
                                                is-aregulation of lymphotoxin A production +
                                                is-aregulation of TRAIL production +
                                                is-aregulation of tumor necrosis factor (ligand) superfamily member 11 production +
                                                is-aregulation of tumor necrosis factor production [GO:0032680] (91 genes, 121 annotations)
                                                        is-anegative regulation of tumor necrosis factor production +
                                                        is-apositive regulation of tumor necrosis factor production +
                                                        is-aregulation of tumor necrosis factor biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        regulatesregulation of cytokine production
                                                is-aregulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of tumor necrosis factor superfamily cytokine production +
                                                        is-apositive regulation of tumor necrosis factor superfamily cytokine production +
                                                        is-aregulation of lymphotoxin A production +
                                                        is-aregulation of TRAIL production +
                                                        is-aregulation of tumor necrosis factor (ligand) superfamily member 11 production +
                                                        is-aregulation of tumor necrosis factor production [GO:0032680] (91 genes, 121 annotations)
                                                                is-anegative regulation of tumor necrosis factor production +
                                                                is-apositive regulation of tumor necrosis factor production +
                                                                is-aregulation of tumor necrosis factor biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        is-atumor necrosis factor superfamily cytokine production
                                                regulatesregulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of tumor necrosis factor superfamily cytokine production +
                                                        is-apositive regulation of tumor necrosis factor superfamily cytokine production +
                                                        is-aregulation of lymphotoxin A production +
                                                        is-aregulation of TRAIL production +
                                                        is-aregulation of tumor necrosis factor (ligand) superfamily member 11 production +
                                                        is-aregulation of tumor necrosis factor production [GO:0032680] (91 genes, 121 annotations)
                                                                is-anegative regulation of tumor necrosis factor production +
                                                                is-apositive regulation of tumor necrosis factor production +
                                                                is-aregulation of tumor necrosis factor biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        is-atumor necrosis factor superfamily cytokine production
                                                is-atumor necrosis factor production
                                                        negatively-regulatesnegative regulation of tumor necrosis factor production +
                                                        positively-regulatespositive regulation of tumor necrosis factor production +
                                                        regulatesregulation of tumor necrosis factor production [GO:0032680] (91 genes, 121 annotations)
                                                                is-anegative regulation of tumor necrosis factor production +
                                                                is-apositive regulation of tumor necrosis factor production +
                                                                is-aregulation of tumor necrosis factor biosynthetic process +
                                                        part-oftumor necrosis factor biosynthetic process +


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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory