Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FBLN1
  • Mouse genes Fbln1
  • Rat genes Fbln1
  • Zfish genes fbln1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fbln1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	FBLN1	IDA		Human	PMID:9278415
Molecular Function	GO:0005201	extracellular matrix structural constituent	FBLN1	IDA		Human	PMID:2269669
Molecular Function	GO:0070051	fibrinogen binding	FBLN1	IPI	UniProtKB:P02676	Human	PMID:7642629
Molecular Function	GO:0001968	fibronectin binding	FBLN1	IPI	UniProtKB:P02751	Human	PMID:1400330
Molecular Function	GO:0001968	fibronectin binding	FBLN1	IPI	UniProtKB:P02751	Human	PMID:9278415
Molecular Function	GO:0042802	identical protein binding	FBLN1	IDA		Human	PMID:1400330
Molecular Function	GO:0042802	identical protein binding	FBLN1	IDA		Human	PMID:25661773
Molecular Function	GO:0042802	identical protein binding	FBLN1	IPI	UniProtKB:P23142	Human	PMID:25661773
Molecular Function	GO:0042802	identical protein binding	FBLN1	IDA		Human	PMID:9278415
Molecular Function	GO:0005178	integrin binding	FBLN1	IPI	UniProtKB:P05556	Human	PMID:25661773
Molecular Function	GO:0016504	peptidase activator activity	Fbln1	IDA		Mouse	PMID:16061471
Molecular Function	GO:0005515	protein binding	FBLN1	IPI	UniProtKB:P05067	Human	PMID:11238726
Molecular Function	GO:0005515	protein binding	Fbln1	IPI	PR:Q61282	Mouse	PMID:16061471
Molecular Function	GO:0005515	protein binding	Fbln1	IPI	PR:P97857	Mouse	PMID:16061471
Molecular Function	GO:0044877	protein-containing complex binding	FBLN1	IPI	ComplexPortal:CPX-1922	Human	PMID:7642629
Cellular Component	GO:0005604	basement membrane	Fbln1	IDA		Mouse	PMID:16061471
Cellular Component	GO:0062023	collagen-containing extracellular matrix	FBLN1	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	FBLN1	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	FBLN1	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	FBLN1	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Fbln1	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0071953	elastic fiber	FBLN1	IDA		Human	PMID:7534784
Cellular Component	GO:0070062	extracellular exosome	FBLN1	HDA		Human	PMID:23533145
Cellular Component	GO:0031012	extracellular matrix	FBLN1	IDA		Human	PMID:2269669
Cellular Component	GO:0005576	extracellular region	FBLN1	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	FBLN1	HDA		Human	PMID:20551380
Cellular Component	GO:0005615	extracellular space	FBLN1	IDA		Human	PMID:2269669
Cellular Component	GO:0005615	extracellular space	Fbln1	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Biological Process	GO:0072378	blood coagulation, fibrin clot formation	FBLN1	IDA		Human	PMID:7642629
Biological Process	GO:0007566	embryo implantation	Fbln1	IEP		Rat	PMID:15112320|RGD:1598926
Biological Process	GO:0035122	embryonic medial fin morphogenesis	fbln1	IGI	ZFIN:ZDB-MRPHLNO-100528-8,ZFIN:ZDB-MRPHLNO-121030-1	Zfish	PMID:22771579
Biological Process	GO:0030198	extracellular matrix organization	Fbln1	IDA		Mouse	PMID:18757743
Biological Process	GO:0030198	extracellular matrix organization	fbln1	IGI	ZFIN:ZDB-MRPHLNO-100528-8,ZFIN:ZDB-MRPHLNO-121030-1	Zfish	PMID:22771579
Biological Process	GO:0007507	heart development	fbln1	IEP		Zfish	ZFIN:ZDB-PUB-980105-5
Biological Process	GO:0090497	mesenchymal cell migration	fbln1	IGI	ZFIN:ZDB-MRPHLNO-100528-8,ZFIN:ZDB-MRPHLNO-121030-1	Zfish	PMID:22771579
Biological Process	GO:0007275	multicellular organism development	fbln1	IEP		Zfish	ZFIN:ZDB-PUB-980105-5
Biological Process	GO:0007162	negative regulation of cell adhesion	FBLN1	IDA		Human	PMID:11792823
Biological Process	GO:2000146	negative regulation of cell motility	FBLN1	IDA		Human	PMID:11792823
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	FBLN1	IDA		Human	PMID:11792823
Biological Process	GO:0001933	negative regulation of protein phosphorylation	FBLN1	IDA		Human	PMID:11792823
Biological Process	GO:2000647	negative regulation of stem cell proliferation	FBLN1	IDA		Human	PMID:11238726
Biological Process	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading	FBLN1	IDA		Human	PMID:11792823
Biological Process	GO:0043589	skin morphogenesis	fbln1	IGI	ZFIN:ZDB-MRPHLNO-100528-8,ZFIN:ZDB-MRPHLNO-121030-1	Zfish	PMID:22771579

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern