Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EZH1
  • Mouse genes Ezh1
  • Rat genes Ezh1
  • Zfish genes ezh1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ezh1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Ezh1	IDA		Rat	PMID:23932971|RGD:9587811
Molecular Function	GO:0042393	histone binding	Ezh1	IDA		Mouse	MGI:MGI:3820717|PMID:19026781
Molecular Function	GO:0046976	histone H3K27 methyltransferase activity	Ezh1	IDA		Mouse	PMID:19303854
Molecular Function	GO:0005515	protein binding	EZH1	IPI	UniProtKB:O75530	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	EZH1	IPI	UniProtKB:O75530	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	EZH1	IPI	UniProtKB:O75530	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	Ezh1	IPI	UniProtKB:Q02395|UniProtKB:Q62315	Mouse	MGI:MGI:4436818|PMID:20064376
Molecular Function	GO:0005515	protein binding	Ezh1	IPI	PR:Q921E6	Mouse	PMID:9584197
Molecular Function	GO:0003714	transcription corepressor activity	Ezh1	IDA		Mouse	MGI:MGI:3820717|PMID:19026781
Cellular Component	GO:0000781	chromosome, telomeric region	Ezh1	IGI	UniProtKB:P38827	Mouse	MGI:MGI:892875|PMID:9214638
Cellular Component	GO:0035098	ESC/E(Z) complex	EZH1	IDA		Human	PMID:20075857
Cellular Component	GO:0035098	ESC/E(Z) complex	Ezh1	IDA		Mouse	MGI:MGI:4436818|PMID:20064376
Cellular Component	GO:0035098	ESC/E(Z) complex	Ezh1	IDA		Mouse	MGI:MGI:3820717|PMID:19026781
Cellular Component	GO:0035098	ESC/E(Z) complex	Ezh1	IDA		Mouse	MGI:MGI:5318799|PMID:22438827
Cellular Component	GO:0035098	ESC/E(Z) complex	Ezh1	IDA		Mouse	MGI:MGI:4429983|PMID:20144788
Cellular Component	GO:0035098	ESC/E(Z) complex	Ezh1	IDA		Mouse	PMID:31451685
Cellular Component	GO:0000792	heterochromatin	Ezh1	IDA		Mouse	MGI:MGI:3820717|PMID:19026781
Cellular Component	GO:0005654	nucleoplasm	EZH1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Ezh1	IDA		Mouse	PMID:9584197
Cellular Component	GO:0005634	nucleus	Ezh1	IDA		Rat	PMID:23932971|RGD:9587811
Biological Process	GO:0006338	chromatin remodeling	Ezh1	IDA		Mouse	MGI:MGI:3820717|PMID:19026781
Biological Process	GO:0140718	facultative heterochromatin formation	Ezh1	IDA		Mouse	MGI:MGI:4436818|PMID:20064376
Biological Process	GO:0036333	hepatocyte homeostasis	Ezh1	IGI	MGI:MGI:107940	Mouse	PMID:25477280
Biological Process	GO:0031507	heterochromatin formation	Ezh1	IDA		Mouse	MGI:MGI:3820717|PMID:19026781
Biological Process	GO:0021766	hippocampus development	Ezh1	IEP		Rat	PMID:23932971|RGD:9587811
Biological Process	GO:0097421	liver regeneration	Ezh1	IGI	MGI:MGI:107940	Mouse	PMID:25477280
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Ezh1	IDA		Mouse	MGI:MGI:3820717|PMID:19026781
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Ezh1	IMP		Mouse	PMID:19303854
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ezh1	IMP		Rat	PMID:23932971|RGD:9587811
Biological Process	GO:1904772	response to tetrachloromethane	Ezh1	IGI	MGI:MGI:107940	Mouse	PMID:25477280
Biological Process	GO:0031509	subtelomeric heterochromatin formation	Ezh1	IGI	UniProtKB:P38827	Mouse	MGI:MGI:892875|PMID:9214638

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern