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Ezh1 Gene Detail
Summary
  • Symbol
    Ezh1
  • Name
    enhancer of zeste 1 polycomb repressive complex 2 subunit
  • Synonyms
    mKIAA0388
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097695
    NCBI Gene: 14055
  • Gene Overview
    MyGene.info: EZH1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:101191115-101226463 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35349 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 64.37 cM, cytoband C-D
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    EZH1, enhancer of zeste 1 polycomb repressive complex 2 subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EZH1, enhancer of zeste 1 polycomb repressive complex 2 subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KMT6B
  • Links
    NCBI Gene ID: 2145
    neXtProt AC: NX_Q92800
    UniProt: Q92800

  • Chr Location
    17q21.2; chr17:42700275-42745096 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20458
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EZH1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, fertile, and healthy. Mice homozygous for a conditional allele activated in hematopoietic stem cells exhibit bone marrow failure with defective HSC maintenance and premature senescence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000002729 VEGA Gene Model | MGI Sequence Detail 35349 C57BL/6J ±  kb
    transcript OTTMUST00000005416 VEGA | MGI Sequence Detail 4207 Not Applicable  
    polypeptide OTTMUSP00000002578 VEGA | MGI Sequence Detail 747 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      73 from dbSNP Build 142
    • PCR
    Protein
    Information
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    Molecular
    Reagents
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    • All nucleic 115
      Genomic 3
      cDNA 108
      Primer pair 3
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
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    MGI:2144579
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 19
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:36024 Abel KJ, et al., Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1. Genomics. 1996 Oct 15;37(2):161-71
    • Latest
      J:257936 Vo LT, et al., Regulation of embryonic haematopoietic multipotency by EZH1. Nature. 2018 Jan 25;553(7689):506-510

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory