Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ERCC4
  • Mouse genes Ercc4
  • Rat genes
  • Zfish genes ercc4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ercc4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1990599	3' overhang single-stranded DNA endodeoxyribonuclease activity	ERCC4	IMP		Human	PMID:14690602
Molecular Function	GO:0003684	damaged DNA binding	ERCC4	IMP		Human	PMID:11790111
Molecular Function	GO:0003677	DNA binding	ERCC4	IDA		Human	PMID:14734547
Molecular Function	GO:0004520	DNA endonuclease activity	ERCC4	IDA		Human	PMID:8797827
Molecular Function	GO:0004520	DNA endonuclease activity	ERCC4	IDA		Human	PMID:10413517
Molecular Function	GO:0004520	DNA endonuclease activity	ERCC4	IDA		Human	PMID:14734547
Molecular Function	GO:0004520	DNA endonuclease activity	ERCC4	IMP		Human	PMID:17055345
Molecular Function	GO:0042802	identical protein binding	ERCC4	IPI	UniProtKB:Q92889	Human	PMID:22483113
Molecular Function	GO:1990841	promoter-specific chromatin binding	Ercc4	IDA		Mouse	PMID:22323595
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:O15360	Human	PMID:12571280
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:Q13813	Human	PMID:12571280
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:Q15554	Human	PMID:14690602
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:Q9NYB0	Human	PMID:14690602
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:P43351	Human	PMID:14734547
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:P07992	Human	PMID:16338413
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:P07992	Human	PMID:17055345
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:P07992	Human	PMID:17289582
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:P07992	Human	PMID:18812185
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:Q8IY92	Human	PMID:19595721
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:Q8IY92	Human	PMID:19595722
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:Q8IY92	Human	PMID:19596235
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:Q8IY92	Human	PMID:19596236
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:Q8IY92	Human	PMID:24012755
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:P07992	Human	PMID:24780295
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:P07992	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:O75410-7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:P07992	Human	PMID:7559382
Molecular Function	GO:0005515	protein binding	ERCC4	IPI	UniProtKB:P07992	Human	PMID:9722633
Molecular Function	GO:0003697	single-stranded DNA binding	ERCC4	IDA		Human	PMID:10413517
Molecular Function	GO:0001094	TFIID-class transcription factor complex binding	Ercc4	IDA		Mouse	PMID:22323595
Cellular Component	GO:0000781	chromosome, telomeric region	ERCC4	IDA		Human	PMID:14690602
Cellular Component	GO:0070522	ERCC4-ERCC1 complex	ERCC4	IPI		Human	PMID:16076955
Cellular Component	GO:0070522	ERCC4-ERCC1 complex	ERCC4	IDA		Human	PMID:14690602
Cellular Component	GO:0070522	ERCC4-ERCC1 complex	ERCC4	IDA		Human	PMID:17055345
Cellular Component	GO:0070522	ERCC4-ERCC1 complex	ERCC4	IDA		Human	PMID:32034146
Cellular Component	GO:0000109	nucleotide-excision repair complex	ERCC4	IDA		Human	PMID:10644440
Cellular Component	GO:0000110	nucleotide-excision repair factor 1 complex	ERCC4	IDA		Human	PMID:10413517
Cellular Component	GO:0005634	nucleus	ERCC4	IDA		Human	PMID:12571280
Biological Process	GO:0034644	cellular response to UV	ERCC4	IGI	UniProtKB:Q15554	Human	PMID:17055345
Biological Process	GO:0034644	cellular response to UV	ERCC4	IDA		Human	PMID:32034146
Biological Process	GO:0006281	DNA repair	ERCC4	IGI	UniProtKB:Q15554	Human	PMID:17055345
Biological Process	GO:0006281	DNA repair	ERCC4	IMP		Human	PMID:19596235
Biological Process	GO:0006281	DNA repair	Ercc4	IMP	MGI:MGI:3028660	Mouse	PMID:14729965
Biological Process	GO:0000724	double-strand break repair via homologous recombination	ERCC4	IMP		Human	PMID:14728600
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	ERCC4	IMP		Human	PMID:14690602
Biological Process	GO:1905768	negative regulation of double-stranded telomeric DNA binding	ERCC4	IDA		Human	PMID:18812185
Biological Process	GO:1905765	negative regulation of protection from non-homologous end joining at telomere	ERCC4	IMP		Human	PMID:14690602
Biological Process	GO:0032205	negative regulation of telomere maintenance	ERCC4	IMP		Human	PMID:17055345
Biological Process	GO:1904357	negative regulation of telomere maintenance via telomere lengthening	ERCC4	IDA		Human	PMID:18812185
Biological Process	GO:0006289	nucleotide-excision repair	ERCC4	IDA		Human	PMID:10644440
Biological Process	GO:0006289	nucleotide-excision repair	ERCC4	IDA		Human	PMID:10413517
Biological Process	GO:0006289	nucleotide-excision repair	ERCC4	IMP		Human	PMID:11790111
Biological Process	GO:0006289	nucleotide-excision repair	ERCC4	IMP		Human	PMID:14728600
Biological Process	GO:0006289	nucleotide-excision repair	ERCC4	IDA		Human	PMID:22547097
Biological Process	GO:0006289	nucleotide-excision repair	ERCC4	IDA		Human	PMID:32034146
Biological Process	GO:0006289	nucleotide-excision repair	ERCC4	IMP		Human	PMID:8797827
Biological Process	GO:1901255	nucleotide-excision repair involved in interstrand cross-link repair	ERCC4	IDA		Human	PMID:32034146
Biological Process	GO:0010506	regulation of autophagy	Ercc4	IMP	MGI:MGI:3028660	Mouse	PMID:18443001
Biological Process	GO:0009411	response to UV	ERCC4	IMP		Human	PMID:16678501
Biological Process	GO:0000723	telomere maintenance	ERCC4	IMP		Human	PMID:14690602
Biological Process	GO:0000723	telomere maintenance	ERCC4	IGI	UniProtKB:Q15554	Human	PMID:17055345
Biological Process	GO:0061819	telomeric DNA-containing double minutes formation	ERCC4	IMP		Human	PMID:14690602
Biological Process	GO:0009650	UV protection	Ercc4	IMP	MGI:MGI:3028660	Mouse	PMID:14729965

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern