About   Help   FAQ
Ercc4 Gene Detail
Summary
  • Symbol
    Ercc4
  • Name
    excision repair cross-complementing rodent repair deficiency, complementation group 4
  • Synonyms
    Xpf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354163
    NCBI Gene: 50505
  • Gene Overview
    MyGene.info: ERCC4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:13109684-13150617 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 8.93 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354163
protein coding gene Chr16:13109684-13152009 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022529
protein coding gene Chr16:10065500-10103751 (+)
A/J MGP_AJ_G0022491
protein coding gene Chr16:9496438-9535688 (+)
AKR/J MGP_AKRJ_G0022467
protein coding gene Chr16:9929014-9970480 (+)
BALB/cJ MGP_BALBcJ_G0022495
protein coding gene Chr16:9660742-9706823 (+)
C3H/HeJ MGP_C3HHeJ_G0022262
protein coding gene Chr16:10008442-10051613 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022944
protein coding gene Chr16:10220337-10265520 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020464
protein coding gene Chr16:9610513-9643328 (+)
CAST/EiJ MGP_CASTEiJ_G0021789
protein coding gene Chr16:10012737-10054399 (+)
CBA/J MGP_CBAJ_G0022231
protein coding gene Chr16:10673397-10719734 (+)
DBA/2J MGP_DBA2J_G0022362
protein coding gene Chr16:9498544-9537888 (+)
FVB/NJ MGP_FVBNJ_G0022338
protein coding gene Chr16:9494192-9528854 (+)
LP/J MGP_LPJ_G0022430
protein coding gene Chr16:9983740-10029332 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022360
protein coding gene Chr16:10334097-10372123 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022957
protein coding gene Chr16:9901842-9937516 (+)
PWK/PhJ MGP_PWKPhJ_G0021531
protein coding gene Chr16:9764382-9800457 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021359
protein coding gene Chr16:9885618-9927182 (+)
WSB/EiJ MGP_WSBEiJ_G0021837
protein coding gene Chr16:9926686-9963178 (+)



Homology
more
  • Human Ortholog
    ERCC4, ERCC excision repair 4, endonuclease catalytic subunit
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ERCC4, ERCC excision repair 4, endonuclease catalytic subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ERCC11, FANCQ, RAD1, XFEPS, XPF
  • Links
    NCBI Gene ID: 2072
    neXtProt AC: NX_Q92889
    UniProt: Q92889

  • Chr Location
    16p13.12; chr16:13920138-13952348 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ercc4 mouse models; 3 with human ERCC4 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice show impaired growth and do not survive longer than several weeks of age. Cultutred cells obtained from mutant mice were shown to be hypersensitive to UV irradiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022545 Ensembl Gene Model | MGI Sequence Detail 40934 C57BL/6J ±  kb
    transcript ENSMUST00000023206 Ensembl | MGI Sequence Detail 3480 Not Applicable  
    polypeptide ENSMUSP00000023206 Ensembl | MGI Sequence Detail 917 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 49

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2146464
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:60251 Shannon M, et al., Characterization of the mouse Xpf DNA repair gene and differential expression during spermatogenesis. Genomics. 1999 Dec 15;62(3):427-35
    • Latest
      J:246103 Chatzinikolaou G, et al., ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes. Nat Cell Biol. 2017 May;19(5):421-432

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory