Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Eps8

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes EPS8
- Mouse genes Eps8
- Rat genes Eps8
- Zfish genes eps8a
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eps8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Eps8	IDA		Mouse	MGI:MGI:5486559\|PMID:15558031
Molecular Function	GO:0003779	actin binding	Eps8	IDA		Mouse	MGI:MGI:5486573\|PMID:11524436
Molecular Function	GO:0003779	actin binding	Eps8	IDA		Mouse	MGI:MGI:4460022\|PMID:20532239
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:Q9UQB8	Human	PMID:15289329
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:Q9UQB8	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:O14936	Human	PMID:16688213
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:Q9UQB8	Human	PMID:19564905
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:Q9UHR4	Human	PMID:21098279
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:P49419	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:Q9UHR4	Human	PMID:22921828
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:Q969U6-1	Human	PMID:23314863
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:Q9UQB8-4	Human	PMID:24076653
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:Q9UQB8-4	Human	PMID:24584464
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:P07910	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:P62993	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:Q06455-4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:Q0D2H9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:Q13895	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:Q15735	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:Q969G3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:Q96GS4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:Q9UFG5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:Q9UQB8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:Q9UQB8	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	EPS8	IPI	UniProtKB:P00533	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Eps8	IPI	UniProtKB:Q8IZP0\|UniProtKB:Q9UQB8	Mouse	MGI:MGI:3799612\|PMID:15289329
Molecular Function	GO:0005515	protein binding	Eps8	IPI	UniProtKB:Q80VW5\|UniProtKB:Q9QZZ4	Mouse	MGI:MGI:5000171\|PMID:21236676
Molecular Function	GO:0005515	protein binding	Eps8	IPI	UniProtKB:P27361\|UniProtKB:Q8CBW3	Mouse	MGI:MGI:3851270\|PMID:19564905
Molecular Function	GO:0005515	protein binding	Eps8	IPI	UniProtKB:Q9QXW2	Mouse	MGI:MGI:5476881\|PMID:23314863
Molecular Function	GO:0005515	protein binding	Eps8	IPI	UniProtKB:Q8CBW3\|UniProtKB:Q8IZP0	Mouse	MGI:MGI:3690183\|PMID:9010225
Molecular Function	GO:0005515	protein binding	Eps8	IPI	UniProtKB:Q8BKX1	Mouse	MGI:MGI:5486554\|PMID:17115031
Molecular Function	GO:0005515	protein binding	Eps8	IPI	UniProtKB:O43813	Mouse	MGI:MGI:4412430\|PMID:19528316
Molecular Function	GO:0005515	protein binding	Eps8	IPI	UniProtKB:Q8CBW3	Mouse	MGI:MGI:5486559\|PMID:15558031
Molecular Function	GO:0005515	protein binding	Eps8	IPI	UniProtKB:Q62245	Mouse	MGI:MGI:5486573\|PMID:11524436
Molecular Function	GO:0005515	protein binding	Eps8	IPI	PR:P35438	Mouse	PMID:17018287
Molecular Function	GO:0005515	protein binding	Eps8	IPI	PR:Q8BKX1	Mouse	PMID:19208628
Molecular Function	GO:0005515	protein binding	Eps8	IPI	PR:Q01098	Mouse	PMID:17018287
Molecular Function	GO:0031267	small GTPase binding	Eps8	IDA		Mouse	MGI:MGI:5486573\|PMID:11524436
Cellular Component	GO:0005903	brush border	Eps8	IDA		Mouse	MGI:MGI:5621262\|PMID:22114352
Cellular Component	GO:0005938	cell cortex	Eps8	IDA		Mouse	MGI:MGI:5486573\|PMID:11524436
Cellular Component	GO:0005938	cell cortex	Eps8	IDA		Mouse	MGI:MGI:5476881\|PMID:23314863
Cellular Component	GO:0070062	extracellular exosome	EPS8	HDA		Human	PMID:11487543
Cellular Component	GO:0070062	extracellular exosome	EPS8	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	EPS8	HDA		Human	PMID:23533145
Cellular Component	GO:0098978	glutamatergic synapse	Eps8	IDA		Mouse	PMID:27450093
Cellular Component	GO:0098978	glutamatergic synapse	Eps8	EXP		Mouse	PMID:27450093
Cellular Component	GO:0098978	glutamatergic synapse	Eps8	IEP		Mouse	PMID:27450093
Cellular Component	GO:0098978	glutamatergic synapse	Eps8	IDA		Rat	PMID:17223277\|RGD:13702448
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	Eps8	IDA		Mouse	PMID:17018287
Cellular Component	GO:0014069	postsynaptic density	Eps8	IDA		Mouse	PMID:17018287
Cellular Component	GO:0014069	postsynaptic density	Eps8	IDA		Rat	PMID:17223277\|RGD:13702448
Cellular Component	GO:0032587	ruffle membrane	Eps8	IDA		Mouse	MGI:MGI:5486573\|PMID:11524436
Cellular Component	GO:0032420	stereocilium	Eps8	IDA		Mouse	MGI:MGI:5607381\|PMID:24741995
Cellular Component	GO:0032420	stereocilium	Eps8	IDA		Mouse	MGI:MGI:5000171\|PMID:21236676
Cellular Component	GO:0032421	stereocilium bundle	Eps8	IDA		Mouse	MGI:MGI:5509070\|PMID:23918390
Cellular Component	GO:0032426	stereocilium tip	Eps8	IDA		Mouse	MGI:MGI:5509070\|PMID:23918390
Cellular Component	GO:0045202	synapse	Eps8	IDA		Mouse	PMID:17018287
Cellular Component	GO:0031982	vesicle	EPS8	HDA		Human	PMID:19190083
Biological Process	GO:0051764	actin crosslink formation	Eps8	IMP		Mouse	MGI:MGI:5486554\|PMID:17115031
Biological Process	GO:0051764	actin crosslink formation	Eps8	IDA		Mouse	MGI:MGI:4460022\|PMID:20532239
Biological Process	GO:0030036	actin cytoskeleton organization	Eps8	IMP	MGI:MGI:3693626	Mouse	PMID:17018287
Biological Process	GO:0051017	actin filament bundle assembly	Eps8	IMP		Mouse	MGI:MGI:5486554\|PMID:17115031
Biological Process	GO:0051017	actin filament bundle assembly	Eps8	IDA		Mouse	MGI:MGI:4460022\|PMID:20532239
Biological Process	GO:0051017	actin filament bundle assembly	Eps8	IGI	MGI:MGI:2137336	Mouse	PMID:19208628
Biological Process	GO:0070358	actin polymerization-dependent cell motility	Eps8	IDA		Mouse	MGI:MGI:5486559\|PMID:15558031
Biological Process	GO:0008344	adult locomotory behavior	Eps8	IMP	MGI:MGI:3693626	Mouse	PMID:17018287
Biological Process	GO:0051016	barbed-end actin filament capping	Eps8	IDA		Mouse	MGI:MGI:5486559\|PMID:15558031
Biological Process	GO:0051016	barbed-end actin filament capping	Eps8	IMP		Mouse	MGI:MGI:5476881\|PMID:23314863
Biological Process	GO:0051016	barbed-end actin filament capping	Eps8	IDA		Mouse	MGI:MGI:4460022\|PMID:20532239
Biological Process	GO:0048149	behavioral response to ethanol	Eps8	IMP	MGI:MGI:3693626	Mouse	PMID:17018287
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Eps8	IEP		Mouse	PMID:20439489
Biological Process	GO:0036336	dendritic cell migration	Eps8	IMP		Mouse	MGI:MGI:5291845\|PMID:21835647
Biological Process	GO:0010458	exit from mitosis	Eps8	IMP		Mouse	MGI:MGI:5476881\|PMID:23314863
Biological Process	GO:0016601	Rac protein signal transduction	Eps8	IDA		Mouse	MGI:MGI:5486573\|PMID:11524436
Biological Process	GO:0030832	regulation of actin filament length	Eps8	IMP		Mouse	MGI:MGI:5000171\|PMID:21236676
Biological Process	GO:0008360	regulation of cell shape	Eps8	IMP		Mouse	MGI:MGI:5476881\|PMID:23314863
Biological Process	GO:0008360	regulation of cell shape	Eps8	IMP		Mouse	MGI:MGI:5486554\|PMID:17115031
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Eps8	IEP		Mouse	PMID:27450093
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Eps8	IDA		Mouse	PMID:27450093
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Eps8	EXP		Mouse	PMID:27450093

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.