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Eps8
Gene Detail
Symbol

Name
ID
Eps8
epidermal growth factor receptor pathway substrate 8
MGI:104684
Feature Type
protein coding gene
Genetic Map
Chromosome 6
66.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:137477245-137654876 bp, - strand
From VEGA annotation of GRCm38

  177632 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3272  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Eps8

Human
homologs
Human Homolog EPS8, epidermal growth factor receptor pathway substrate 8
NCBI Gene ID 2059
neXtProt AC  NX_Q12929
Human Synonyms  DFNB102
Human Chr (Location)  12p12.3; chr12:15620141-15789576 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human EPS8
Mutations,
alleles, and
phenotypes
All mutations/alleles(87) : Gene trapped(85) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in resistance to some of the intoxicating effects of ethanol and increased ethanol consumption. NMDA receptor currents and their sensitivity to inhibition by ethanol are abnormal.
 
Interactions
Eps8 interacts with 296 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process actin crosslink formation, actin cytoskeleton reorganization, ...
Component cell cortex, cell junction, ...
Function actin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (242)    Tissues (108)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 223
Northern blot 8
RT-PCR 11
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(14) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022767 (Evidence)
Ensembl Gene ModelENSMUSG00000015766 (Evidence)
Entrez Gene13860 (Evidence)
DFCITC1576874, TC1613539, TC1656653, TC1702523
DoTSDT.101380644, DT.110484208, DT.91592857, DT.94151440, DT.97375955, DT.97382552
NIA Mouse Gene IndexU027983
PDB1AOJ, 1I0C, 1I07
Consensus CDS ProjectCCDS20665.1
International Mouse Knockout Project StatusEps8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022767 VEGA Gene Model | MGI Sequence Detail 177632 C57BL/6J ±  kb
transcript OTTMUST00000054652 VEGA | MGI Sequence Detail 4567 Not Applicable 
polypeptide OTTMUSP00000026105 VEGA | MGI Sequence Detail 821 Not Applicable 

For the selected sequences
All sequences(96) RefSeq(14) UniProt(8)
Polymorphisms
SNPs within 2kb(3593 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR013625 Tensin phosphotyrosine-binding domain
Protein Ontology PR:000007147 epidermal growth factor receptor kinase substrate 8
References
(Earliest) J:34029 Fazioli F, et al., Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals. EMBO J. 1993 Oct;12(10):3799-808
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(59)
Other
accession IDs
MGD-MRK-27047, MGI:2141675

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory